Persyst Development

Solana Beach, California, United States All United States companies → — Founded 1987

Specialty-Focused AI

Critical Care Neurology

Neurology AI

Funding Raised (Grant) — undisclosed

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Products

Persyst 14 EEG Review and Analysis Software

Persyst Development Corporation

Neurology AI

Persyst 14 EEG Review and Analysis Software offers AI-powered seizure and spike detection, continuous artifact reduction, and comprehensive trending for neurologists. It integrates seamlessly with major EEG systems and is used by top neurology hospitals.

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About Persyst Development

Persyst Development Corporation is a leading healthcare AI company specializing in advanced electroencephalography (EEG) analysis products. Their flagship software, Persyst 15, provides a comprehensive suite of tools for Computer Assisted Review of EEG (C.A.R.E), which includes sophisticated seizure and spike detection, customizable EEG trends, and real-time artifact reduction. The software is widely adopted, with 97 out of 100 of the top hospitals for Neurology in the U.S. reportedly using Persyst for EEG monitoring and review.

For physicians, Persyst’s solutions are designed to enhance efficiency and improve patient outcomes across various clinical environments, including continuous EEG monitoring, long-term monitoring (LTM), and ambulatory EEG. The company leverages deep learning and artificial intelligence to develop clinically validated advances, such as the Persyst Seizure Detector, which has demonstrated high sensitivity and a low false positive rate for adult EEG data, and a new Neonatal Seizure Detector. Persyst also offers mobile solutions like Persyst Mobile, enabling secure and quick remote EEG review on web, iOS, or Android devices, and supports intracranial EEG (iEEG) analysis with tools for electrode localization and trending.

Focus Areas

Seizure Detection Spike Detection Quantitative EEG Analysis Artifact Reduction EEG Trending EEG Electrical Source Imaging (ESI) Intracranial EEG (iEEG) Analysis Continuous EEG Monitoring Long-Term Monitoring (LTM) Ambulatory EEG Neonatal Seizure Detection Neurocritical Care Monitoring

Business Intelligence

Key Investors	None known (traditional VC funding)
Partnerships	Epilog (for ESI), Nihon Kohden America, Neurovirtual, Natus Neurology (including Natus BrainWatch), Micromed, Compumedics Limited, Cadwell Laboratories, Inc., Moberg ICU Solutions
Technology	AI, Deep Learning, Cloud-native (for ESI), Windows-based software, integrated with major EEG manufacturers' hardware and software, PACS integration
FDA Clearances	Multiple (at least 2 for Persyst 15 EEG Review and Analysis Software: K252160, K222002) cleared products (estimated)

What Physicians Need to Know

Seizure Detection

Persyst utilizes advanced neural network technology and deep learning to provide highly sensitive (up to 95% for adult EEG) and accurate seizure detection with a significantly lower false positive rate compared to previous generations. It includes a specialized Neonatal Seizure Detector capable of operating on reduced electrode arrays, and offers near real-time notifications to assist clinicians in monitoring.

Spike Detection

The software employs advanced neural networks across various montages to identify sharps and spikes, analyzing EEG background, artifact presence, waveform morphology, and voltage field spread. Recent updates have improved accuracy, particularly in pediatric and normal EEGs, and refined the distinction between generalized and focal spikes, freeing up clinician time for advanced analysis.

Quantitative EEG Analysis (qEEG) & EEG Trending

Persyst Trending offers a comprehensive and flexible solution for quantitative EEG analysis, extracting statistical features not immediately apparent in raw EEG. It provides customizable tools for calculating and displaying various trends, all based on Artifact Reduction to ensure the trends primarily represent cerebral activity. This enhances diagnostic capabilities and improves efficiency in reviewing long EEG recordings.

Artifact Reduction

Persyst provides robust artifact reduction capabilities, including push-button removal of EMG, eye movement, and electrode artifacts from standard 10-20 EEG recordings. This feature is crucial for improving the interpretability of EEG features, trends, and detection results, leading to more accurate analysis and fewer false positives.

EEG Electrical Source Imaging (ESI)

Persyst ESI is a neuroimaging modality that co-registers a patient's EEG data with their MRI to localize the source of scalp EEG signals within the brain. It offers sub-lobar accuracy using Current Density Reconstruction (sLORETA) and patient-specific head models, making it a practical and accessible tool for presurgical evaluation without requiring additional hardware or specialized expertise.

Intracranial EEG (iEEG) Analysis

Persyst offers tools for iEEG imaging and analysis, although specific performance for spike detection in intracranial recordings has not been assessed.

Continuous EEG Monitoring & Long-Term Monitoring (LTM)

The software is integrated with major EEG acquisition systems, providing time-synchronized, continuous trending of EEG and physiological data, along with online spike and seizure detection during acquisition. It supports multi-patient monitoring and offers solutions for remote access and review, ideal for EMU and ICU settings.

Ambulatory EEG

Persyst provides review capabilities for ambulatory EEG, including artifact reduction, spike detection, and seizure detection for supported formats.

Neonatal Seizure Detection

A dedicated Neonatal Seizure Detector in Persyst 15 allows clinicians to efficiently assess and quantify seizure burden in neonates, even with reduced electrode arrays (down to three electrodes).

Neurocritical Care Monitoring

Persyst offers solutions tailored for neurocritical care environments, providing comprehensive EEG monitoring and analysis to support critical patient management.

Physician Tip

For physicians, Persyst Development's software, particularly Persyst 15, stands out by significantly enhancing efficiency and accuracy in EEG interpretation. The advanced AI and deep learning algorithms for seizure and spike detection can reduce review time and minimize missed events, improving patient safety and outcomes. The comprehensive trending and artifact reduction tools provide clearer insights into cerebral activity, while EEG Electrical Source Imaging (ESI) offers practical localization of seizure sources. The seamless integration with major EEG systems and mobile accessibility (Persyst Mobile) allow for flexible and timely patient monitoring and review, whether at the bedside or remotely. This translates to more informed clinical decision-making and streamlined workflows in busy clinical practices.

Persyst is uniquely integrated with all major EEG manufacturers, including Micromed, Natus, Nihon Kohden, Cadwell, and Compumedics. This comprehensive integration ensures compatibility and ease of use, facilitating seamless adoption in diverse clinical settings. The software also supports mobile platforms (iOS, Android, Web) for remote monitoring and review.

At a glance

Founded 1987

HQ Solana Beach, California, United States · United States

Team size 21-50

CEO Nicolas Nierenberg

Funding Funding Raised (Grant) — undisclosed

FDA clearances Multiple (at least 2 for Persyst 15 EEG Review and Analysis Software: K252160, K222002) (estimated)

Products 1

Products by Persyst Development

1 product in the directory

Persyst 14 EEG Review and Analysis Software

Persyst Development Corporation

Neurology AI

Contact for pricing

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Press & Coverage

FDA

Persyst 15 EEG Review and Analysis Software Receives FDA 510(k) Clearance

Persyst Development LLC received 510(k) clearance from the FDA for its Persyst 15 EEG Review and Analysis Software, intended for review, monitoring, and analysis of EEG recordings to aid neurologists. The clearance, dated October 31, 2025, covers features like seizure detection, spike detection, and quantitative EEG analysis.

2025-10

PR Newswire

Natus announces FDA 510(k) clearance for electrographic status epilepticus diagnostic indication in BrainWatch point-of-care EEG solution

Natus Medical Incorporated announced FDA 510(k) clearance for the electrographic status epilepticus diagnosis capability of its BrainWatch point-of-care EEG solution, which integrates Persyst 15 analysis software. This allows for improved diagnosis and monitoring of electrographic status epilepticus.

2025-12

Journal of Integrative Neuroscience

Diagnostic Accuracy of the Persyst Automated Seizure Detector in the Neonatal Population

A study published in August 2024 found that the Persyst neonatal automated seizure detection algorithm (SDA) demonstrates high diagnostic accuracy in identifying neonatal seizures, comparable to adult SDAs and amplitude-integrated EEG. The study suggests further investigation is needed to confirm optimal seizure probability thresholds in a larger patient cohort.

2024-08

Persyst Development LLC

Persyst 15 Release

Persyst 15, released in November 2023, introduces significant enhancements including a new neonatal-specific seizure detector leveraging deep learning and AI, improved neuroimaging tools with an MRI viewer for ESI results, and enhanced spike review capabilities. It also features Persyst Prime for optimized support and access to advanced clinical tools.

2023-11

Persyst Development LLC

Persyst Mobile and Mobile Bridge Release

Persyst Mobile, a universal EEG monitoring and review application for iOS, Android, and Web, was released in November 2023. It offers secure, end-to-end encrypted access to EEG data, trends, and video, integrating with hospital security infrastructure.

2023-11

Journal of Neurology

Real-world evaluation of an automated EEG spike detection software in a tertiary centre compared to a clinical reference standard

A January 2026 study evaluated the Persyst P15 spike detection software, finding a high negative predictive value (96.3%) for ruling out interictal epileptiform discharges (IEDs) in routine EEGs, but a low positive predictive value (19.9%). This suggests Persyst is good for ruling out IEDs but may produce many false positives.

2026-01

Persyst Development LLC

Persyst 15Rev.C Release Notes

Persyst 15Rev.C, released in February 2026, includes major enhancements for visualizing and analyzing multi-modal iEEG data, PACS integration for direct DICOM image upload, and an improved spike detector with increased sensitivity and decreased false positives, especially in pediatric and normal EEG data.

2026-02

Journal of Neurology, Neurosurgery & Psychiatry

Evaluation of the accuracy of the Persyst system in automated detection of interictal epileptiform discharges

A study is underway to evaluate the Persyst system's accuracy in detecting interictal epileptiform discharges (IEDs) against a trained neurophysiologist's assessment in a large, heterogeneous patient cohort. This validation is crucial for clinical adoption and trust in the automated system.

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Frequently Asked Questions

What core EEG analysis capabilities does Persyst Development offer for continuous and long-term monitoring?

Persyst Development's software, particularly Persyst 15, provides comprehensive tools for continuous and long-term EEG monitoring, including real-time seizure and spike detection, quantitative EEG analysis, and artifact reduction. It offers customizable EEG trending, which is crucial for efficiently reviewing extensive recordings in both ICU and epilepsy monitoring unit (EMU) settings.

How does Persyst address specialized EEG analysis needs like Intracranial EEG (iEEG) and Electrical Source Imaging (ESI)?

Persyst 15 includes advanced tools for Intracranial EEG (iEEG) analysis, featuring intracranial electrode localization with millimeter resolution and automated montage and trend creation to streamline review of complex datasets. For Electrical Source Imaging (ESI), Persyst integrates with Epilog's clinically validated data processing pipeline, allowing localization of scalp EEG signal sources using co-registered MRI data and export of 3D electrode positions in DICOM format.

What regulatory compliance and data security standards does Persyst Development meet?

Persyst Development's software, Persyst 15, is FDA 510(k) cleared and holds CE/MDR, ONC, and ISO 13485 certifications, ensuring its adherence to medical device regulations. The company also complies with HIPAA, SOC 2, and ISO 27001 standards, demonstrating a strong commitment to data security and patient privacy.

What kind of support and training does Persyst Development provide to healthcare professionals?

Persyst offers comprehensive support and training, including direct phone support for urgent issues and scheduled remote sessions for non-urgent questions, configuration, licensing, and customized training. Their 'Persyst Primeu2122 Priority Support' program provides access to clinical application support, rapid resolution, and tailored training sessions to optimize workflows and system utilization.

How does Persyst integrate with existing hospital systems and EEG hardware?

Persyst is designed for seamless integration with major EEG acquisition systems from manufacturers like Natus, Nihon Kohden, Cadwell, Micromed, and Compumedics, and supports nearly 70 different data formats. It also integrates with hospital IT infrastructure, including PACS, Epic, and Cerner, to streamline workflows for imaging and patient data management.

What is Persyst Development's approach to neonatal seizure detection and neurocritical care monitoring?

Persyst 15 features a new, FDA-cleared Neonatal Seizure Detector that leverages deep learning and AI, operating effectively even on reduced electrode arrays. For neurocritical care, their ICU Continuous Monitoring product provides real-time trending, artifact reduction, and seizure/spike detection, designed for environments requiring comprehensive EEG capabilities.

What is the pricing model for Persyst software, and are there options for cost-effective deployment across a large institution?

Persyst operates on a subscription-based pricing model, with specific details available upon direct inquiry. They offer 'Persyst Primeu2122 Priority Support' which includes cost savings through indefinite renewals, volume discounts, and flexible licensing options to accommodate the needs of large institutions and ensure compatibility with evolving operating systems and EEG hardware.

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