High Alpha

High Alpha is an Indianapolis-based venture studio and fund that creates and backs B2B software-as-a-service platforms, including healthcare-focused Health IT companies. The studio model is the firm’s defining feature: rather than only investing in existing companies, High Alpha creates new businesses internally and invests in external founders pursuing related theses. The result is a portfolio with deep operational fingerprints, strong product orientation, and a network of founders and operators who have repeatedly built and scaled enterprise software companies in mid-sized markets.

The firm invests at Pre-Seed, Seed, and Series A with check sizes typically in the one to five million dollar range, depending on the structure of the company and the relationship. The studio orientation means engagement often starts earlier than at typical venture firms, and the team brings substantive operational support during the formative phase. Geographic preference is broadly oriented toward the Midwest, particularly Indiana, though the firm considers founders elsewhere when the profile fits the SaaS-focused thesis.

For founders, High Alpha offers a partner whose deep operational experience in B2B software translates into substantive engagement on product, distribution, hiring, and capital allocation. Diligence emphasizes the strength of the founding team, the clarity of the customer hypothesis, and the capital efficiency of the early business model. Partners are direct, opinionated, and accustomed to working closely with management teams during the early scaling phase. The strongest fits are founders building enterprise SaaS businesses who want substantive operational partnership and appreciate the studio model’s hands-on approach. There is limited public information regarding specific partner names beyond what is broadly visible in the firm’s external presence.