High Country Venture

VC Boulder, United States · Founded 2005

About High Country Venture

High Country Venture is a Boulder-based regional venture firm that invests heavily into early-stage life sciences, biotechnology, and diagnostic platforms across Colorado and the broader Mountain West. The firm draws on the scientific density of Boulder and Denver, including ties to the University of Colorado system and CU Anschutz, and concentrates on technical founders building defensible biotech, biotechnology tools, and medical device companies. Within healthcare, focus areas include biotech and medical devices and medtech, with particular attention to platforms with clear scientific differentiation, defensible IP positions, and credible paths through clinical or regulatory milestones. The team is comfortable engaging with academic spinouts and prefers companies where commercialization questions are paired with serious scientific rigor. High Country Venture typically engages at the seed and Series A stages, with check sizes generally in the 1M to 5M range. The firm is comfortable leading or co-leading early rounds in Colorado and joining strong syndicates elsewhere, with reserves for selective follow-on participation. Geographic focus is Colorado-led, with broader Mountain West coverage and selective participation in companies elsewhere that have clear connections to the regional ecosystem. Founders engaging High Country Venture should expect technically grounded diligence, attention to IP and translational strategy, and post-investment support around scientific advisory recruitment, regional clinical partnerships, and introductions to follow-on investors familiar with life sciences risk profiles. The firm tends to favor founders with deep technical conviction and patience for the timelines inherent in life sciences development. Limited public information is available on individual investment partners and current portfolio details.

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Team

Mark T. Lupa
Managing Partner

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Last updated 2026-05-06. Sourced from this fund's published materials.
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