2150

2150 is a London and Copenhagen based venture firm built around a single thesis: the urban stack is the largest carbon and resource sink on the planet, and the technologies that rebuild it are also where some of the most defensible deeptech companies of the next decade will emerge. For physician-facing AI founders, 2150 is a less obvious name, but the fund’s mandate around the urban environment, indoor air, water, materials, and human resilience pulls them into health-adjacent deeptech where AI and biology meet the built world.

The thesis covers the full lifecycle of cities, from how they are designed and constructed through how they are powered, occupied, and eventually decarbonised. Within that, the team has shown appetite for AI-driven diagnostics where the input is environmental or biological signal, computational tools for biotech and life sciences, and platforms that quantify human health outcomes from urban exposure. They are not a general digital health investor; a telehealth app or a SaaS scheduler will not get traction here. A startup using AI to predict disease burden from air quality, or to design therapeutics targeting ageing in dense urban populations, is more on-thesis than it sounds.

Check sizes typically range from five to twenty-five million dollars at Series A and Series B, with the firm comfortable leading rounds. The geographic focus is European founders with global ambition, and the team will travel for the right opportunity in North America. They invest with conviction and concentration, which means a smaller portfolio and more board involvement per company than a typical multi-stage fund.

2150 was founded by a partner team with backgrounds spanning real estate, engineering, climate, and venture, and the firm pairs that with technical advisors across materials science, computational biology, and energy systems. Diligence tends to be deep on physics, chemistry, and biology, and the firm is comfortable with longer timelines to commercial milestones than a generalist Series A fund.

The right path in is a warm introduction from a 2150 portfolio founder, a climate or deeptech operator in the network, or an LP relationship; the team also runs visible thought leadership, panels, and events, and pays attention to founders who show up with a clear point of view. Approach when you have a working technology, a credible scientific moat, and either early commercial evidence or a clearly defined first deployment partner. Bring a thesis on how your work reduces carbon, resource use, or human health burden in cities, with hard numbers, not slogans. Founders building general-purpose physician AI tools without an urban or environmental thread will not be a fit, and it is better to recognise that early than to spend cycles trying to retrofit the story.