Serena is an operationally-driven venture capital firm that partners with early-stage startups from pre-seed to Series A, with a strong focus on applied AI, digital health, and deep technology transitions.
About Serena
Serena is a Paris-based generalist venture firm investing across consumer technology, B2B software, fintech, and selectively in health technology, with a portfolio that has historically included digital health and life-sciences-adjacent businesses. Stage focus is typically Series A and B, with checks in the EUR 2M to 10M range and the depth to lead. Healthcare exposure is opportunistic and most credible in digital health, applied AI for clinical workflows, and selectively life-sciences software; the firm operates a community-and-coach model that adds operating support to portfolio companies. Physician founders building European-anchored digital health, clinical AI, or B2B health software with credible commercial momentum are the right profile. Founders building therapeutics, devices, consumer wellness brands, or US-only commercial models without European center of gravity should pitch elsewhere. Geographic posture is European-led with French anchor and broader EU deal capacity. The realistic entry path is a warm introduction from a Serena portfolio CEO, a co-investing French seed fund, or a French ecosystem operator; the partners are responsive but prefer referred deals. Founders should arrive with traction signal, defended unit economics, and a credible European expansion narrative. Treat Serena as one of the more credible French generalist partners for software-shape healthcare companies and a thoughtful Series A lead, particularly for founders with French or broader European engineering centers of gravity.
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