Aquilion ONE

by Canon Medical Systems Corporation  · Based in Japan → — Designed for deep intelligence
Cardiology Emergency Medicine Radiology
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Regulatory Status Disclosed

Overview

The Aquilion ONE series, developed by Canon Medical Systems Corporation, represents a line of advanced Computed Tomography (CT) scanners that integrate cutting-edge artificial intelligence (AI) technologies to enhance diagnostic imaging and workflow efficiency. These systems are designed to provide comprehensive, high-quality imaging across various clinical applications, including cardiology, neurology, pulmonology, and interventional radiology.

Key to the Aquilion ONE’s capabilities are its AI-powered features such as the Advanced intelligent Clear-IQ Engine (AiCE) and Precise IQ Engine (PIQE) Deep Learning Reconstruction (DLR). These technologies utilize deep learning to differentiate true signal from noise, delivering sharp, clear, and distinct images at fast speeds while enabling ultra-low dose scanning. The systems also feature wide-area detectors, allowing for full organ coverage in a single rotation, and AI-assisted workflow automation (e.g., INSTINX) to streamline operations and improve consistency.

The Aquilion ONE / PRISM Edition, for example, combines Deep Learning Spectral Reconstruction with AiCE, maximizing both conventional and spectral CT capabilities. This integration provides intelligent clinical insights to assist physicians in making more informed decisions throughout the patient’s care cycle. The focus is on improving patient outcomes through enhanced image quality, reduced radiation dose, and optimized clinical workflows.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • Advanced intelligent Clear-IQ Engine (AiCE) Deep Learning Reconstruction (DLR)
  • Precise IQ Engine (PIQE) Deep Learning Reconstruction (DLR) for super resolution images
  • Deep Learning Spectral Imaging and Reconstruction
  • Wide-area detector (e.g., 16 cm) for single-rotation organ coverage
  • Ultra-fast rotation speed (e.g., 0.24 seconds)
  • AI-assisted workflow automation (e.g., INSTINX)
  • Ultra-low dose scanning with technologies like SilverBeam Filter
  • Motion artifact correction (e.g., CLEAR Motion DLR)
  • High-quality cardiac CT studies in one beat
  • Integrated end-to-end spectral workflow

Use Cases

  • Cardiac CT imaging (e.g., structural heart, coronary imaging)
  • Neuro CT imaging (e.g., stroke evaluation)
  • Lung cancer screening and lung imaging
  • Interventional radiology procedures (e.g., Angio-CT hybrid solutions)
  • Whole-body CT scanning
  • Musculoskeletal (MSK) imaging

What Physicians Need to Know

DICOM Support & Standards
The Aquilion ONE systems fully comply with DICOM and IHE standards, ensuring seamless communication and integration within hospital networks. DICOM Conformance Statements are readily available for various Aquilion ONE models.
PACS Integration Method
Designed for robust integration, Aquilion ONE systems facilitate direct image delivery to PACS and reading stations. Canon Medical's Vitrea Advanced Visualization applications are integrated to support comprehensive spectral data analysis and network-wide access.
Reading Room Workflow Impact
AI-assisted workflow automation, such as INSTINX and Anatomical Landmark Detection (ALD), significantly enhances operational efficiency by automating scan planning, protocol setup, and post-processing. This can reduce workflow steps by up to 40% and scan planning time by 24%, leading to faster procedures, improved consistency across operators, and reduced cognitive load.
AI Model Architecture (deep learning approach)
The core AI technology is Deep Learning Reconstruction (DLR), specifically the Advanced intelligent Clear-IQ Engine (AiCE) and Precise IQ Engine (PIQE). These utilize deep convolutional neural networks (DCNNs) trained on vast amounts of high-quality image data to differentiate true signal from noise, suppress noise, and enhance spatial resolution. PIQE offers Super Resolution DLR.
Processing Speed (per study)
AiCE DCNN reconstruction speeds are optimized for busy clinical environments. The Aquilion ONE / INSIGHT Edition enables ultra-fast acquisitions with a 0.241-second rotation speed for head-to-toe scans. Comprehensive stroke evaluations with 4D brain perfusion can be completed in under five minutes.
FDA Clearance Pathway (510k/De Novo)
Canon Medical has received 510(k) clearance for its AiCE Deep Learning Reconstruction technology across various Aquilion ONE CT systems and other modalities.
Supported Modalities (CT/MRI/X-ray/US)
While the Aquilion ONE is a CT scanner, Canon Medical's AI reconstruction technology (AiCE) is integrated across its CT portfolio and has expanded to MRI (Vantage Orian, Vantage Galan) and PET/CT (Cartesion Prime). AI-assisted algorithms have also received FDA clearance for ultrasound.
Sensitivity & Specificity Data
For Canon Medical's Stroke CT Package, automated Intracranial Hemorrhage (ICH) detection shows a sensitivity of 0.93 and specificity of 0.93. Large Vessel Occlusion (LVO) detection demonstrates a sensitivity of 0.73 and specificity of 0.98. AiCE can achieve equivalent low contrast detectability to filtered back projection (FBP) with 69.0% to 81.0% less dose in simulated phantoms and offers the potential for a 52-53% reduction in volume CT dose index in clinical practice.
RSNA/ACR Validation
Canon Medical regularly showcases its AI advancements at major conferences like RSNA. The Aquilion ONE / INSIGHT Edition was honored as the 2024 Best New Radiology Device by the prestigious Minnies Awards, announced at RSNA 2024.
Physician Tip

Leverage the AI-powered Deep Learning Reconstruction (AiCE, PIQE) for superior image quality at reduced dose, particularly beneficial for challenging cases like cardiac imaging with stents or heavily calcified vessels, and pediatric studies. Utilize AI-assisted workflow automation (INSTINX) to streamline scan planning, protocol setup, and post-processing, freeing up time for patient interaction and complex case analysis. For acute stroke cases, rely on the integrated AI tools for automated ICH and LVO detection to expedite diagnosis and treatment decisions. Explore the Deep Learning Spectral Imaging capabilities for advanced material differentiation and quantitative analysis, enhancing diagnostic confidence.

The Aquilion ONE system, with its integrated AI features, is designed for robust integration within existing hospital IT infrastructure. It fully supports DICOM and IHE standards for seamless communication with PACS and other medical imaging systems. Advanced visualization applications (e.g., Vitrea) are integrated to facilitate comprehensive spectral data analysis and direct delivery of images to reading stations, supporting a hospital-wide network. Canon Medical also offers protocol management solutions for standardized and secure protocol distribution across CT scanners.

Details

Category Radiology & Imaging AI
Pricing Contact vendor — Not publicly disclosed.
DeploymentOn-premise hardware
Compliance
BAA AvailableUnknown AI-estimated
HIPAA CompliantUnknown AI-estimated
FDA Status Yes AI-estimated

The Aquilion ONE (TSX-308A/3) V1.5 received FDA 510(k) clearance (K242403) on December 23, 2024, for whole-body multi-slice helical CT scanning, including AI enhancements like PIQE for cardiac, abdomen and pelvis, and lung applications. Other versions, such as the Aquilion ONE / INSIGHT Edition, have also received FDA 510(k) clearance.
Integrations
EHR Not specified
Specialties Cardiology, Emergency Medicine, Radiology

What the Web Says

The Toshiba (now Canon Medical Systems) Aquilion ONE is generally well-regarded in the medical community, particularly for its single-rotation whole-organ imaging capabilities and high image quality. Physicians appreciate its speed and ability to reduce radiation dose, while also noting its significant cost and the learning curve associated with its advanced features.

Overall: Positive

Strengths

  • Single-rotation whole-organ coverage (320-slice detector)
  • High image quality and spatial resolution
  • Reduced radiation dose compared to older CT scanners
  • Fast scan times, beneficial for pediatric and uncooperative patients
  • Improved workflow and diagnostic confidence
  • Advanced cardiac imaging capabilities

Limitations

  • High initial cost and ongoing maintenance expenses
  • Steep learning curve for new operators due to advanced features
  • Large footprint requiring significant space
  • Potential for motion artifacts in very uncooperative patients despite speed
  • Software updates can be complex and time-consuming
  • Specific advanced features may not be utilized by all facilities

Based on reviews from: AuntMinnie.com, Radiology forums/discussions, Medical journal articles (e.g., European Radiology, AJR), Healthcare IT reviews, Physician testimonials/interviews

Last updated: 2026-07-20

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Press & Coverage

Canon Medical Systems USA
Canon Medical Systems Announces Regulatory Clearance for New CT Imaging Innovation
Canon Medical Systems has received regulatory clearance for major AI enhancements to its Aquilion ONE / INSIGHT Edition, including the new PIQE 1024 matrix and SilverBeam across a broader range of clinical applications. These innovations are also being introduced to the Aquilion ONE / PRISM Edition.
2025-03
Canon Medical Systems USA
Canon Medical Systems USA Unveils Their Latest Innovation in Interventional Imaging: Alphenix 4D CT with Aquilion ONE/INSIGHT Edition u2013 Now U.S. Food and Drug Administration (FDA) 510(k) Cleared
Canon Medical announced FDA 510(k) clearance for its Alphenix 4D CT with Aquilion ONE/INSIGHT Edition, an advanced interventional imaging system combining angiography with the Aquilion ONE/INSIGHT Edition CT scanner. The system is scheduled for commercial availability in summer 2026.
2025-11
Canon Medical Systems USA
Canon Medical Systems' Aquilion ONE / INSIGHT Edition Wins the 2024 Best New Radiology Device at the Minnies Awards
Canon Medical Systems' Aquilion ONE / INSIGHT Edition CT scanner was awarded the 2024 Best New Radiology Device at the Minnies Awards, recognizing its pioneering technology and enhanced clinical workflows, including Precise IQ Engine (PIQE) Deep Learning Reconstruction and INSTINX AI-assisted workflow.
2024-11
RAD Magazine
Royal Bournemouth Hospital is first to install Aquilion One/Insight Edition CT system in the UK
Royal Bournemouth Hospital in the UK and the University of Strasbourg in France are the first European healthcare facilities to install the Aquilion One/Insight Edition CT system, featuring Instinx workflow and deep learning reconstruction technology for simplified and efficient scans.
2024-05
FDA
Aquilion ONE (TSX-308A/3) V1.4 with PIQE Reconstruction System 510(k) Clearance
The FDA granted 510(k) clearance for the Aquilion ONE (TSX-308A/3) V1.4 with PIQE Reconstruction System, a deep learning reconstruction method designed to enhance spatial resolution and reduce noise for various clinical applications.
2024-04
HealthManagement.org
Canon Medical Introduces Aquilion One
Canon Medical Systems Europe B.V. introduced the Aquilion ONE / PRISM Edition, a spectral CT system combining the Advanced intelligent Clear IQ Engine (AiCE) with Deep Learning Spectral Reconstruction imaging capabilities for routine confident diagnoses.
2020-04
Diagnostic and Interventional Cardiology
Canon Medical Systems Secures FDA Clearance for Aquilion ONE/PRISM Edition
Canon Medical Systems received 510(k) clearance from the U.S. Food and Drug Administration for the Aquilion ONE/PRISM Edition, which integrates AI technology to maximize conventional and spectral CT automated workflow capabilities.
2020-02
Journal of Vascular and Interventional Neurology
Mean transit time on Aquilion ONE and its utilization in patients undergoing acute stroke intervention
This peer-reviewed article discusses the utility of the mean transit time (MTT) map on computed tomography perfusion (CTP) imaging using an Aquilion ONE CT scanner in patients with acute large vessel ischemic stroke.
2012-11

Videos

Product demos, reviews, and walkthroughs for Aquilion ONE.

View all on YouTube

Frequently Asked Questions

The Aquilion ONE integrates AI through features like the Advanced intelligent Clear-IQ Engine (AiCE) and Precise IQ Engine (PIQE) Deep Learning Reconstruction, which significantly reduce noise and enhance image sharpness for improved diagnostic confidence across various anatomies. Additionally, AI-assisted workflow automation, such as INSTINX and the New User Experience, streamlines scan planning and operation, leading to faster and more efficient exams.
The Aquilion ONE / PRISM Edition and Aquilion ONE / INSIGHT Edition, including their AI-driven enhancements like PIQE and SilverBeam Filter, have received 510(k) clearance from the U.S. Food and Drug Administration (FDA). This clearance indicates that the device and its AI components are deemed safe and effective for clinical use, meeting established regulatory standards for medical devices.
Yes, other major CT manufacturers such as GE HealthCare, Philips, and Siemens Healthineers offer competing CT systems that also incorporate advanced AI for image reconstruction, dose management, and workflow optimization. These alternatives may include technologies like photon-counting CT and various deep learning reconstruction algorithms, providing a range of options for physicians seeking AI-enhanced imaging.
Specific new pricing for the Aquilion ONE is not publicly disclosed by the manufacturer, as it can vary based on configuration, regional factors, and service agreements. However, market data for used or refurbished Aquilion ONE systems indicates a price range typically from approximately $250,000 to $782,450, with an average around $455,817. New systems with advanced AI features would likely be a significant investment above these figures.
While the Aquilion ONE's AI significantly improves image quality and workflow, potential limitations include the necessity for optimal scanning protocols to ensure maximum AI accuracy, as different scanner models and local CT perfusion protocols can influence AI software performance. Physicians should also be aware that while AI aids in image processing and workflow, clinical interpretation and decision-making remain paramount.
The Aquilion ONE utilizes AI technologies like the Advanced intelligent Clear-IQ Engine (AiCE) and the SilverBeam Filter to achieve substantial radiation dose reduction, reportedly up to 80% compared to traditional methods, without compromising image quality. AiCE enhances low-contrast resolution and reduces noise, while SilverBeam optimizes the X-ray beam, allowing for diagnostic confidence at ultra-low dose levels.
The Aquilion ONE's AI-assisted workflow automation, such as INSTINX, is designed for intuitive operation and can be incorporated into routine protocols, suggesting a degree of adaptability for various clinical needs. While the core deep learning reconstruction algorithms are pre-trained, the system's overall workflow can be optimized to support specific departmental protocols and potentially facilitate research applications through its comprehensive data acquisition and processing capabilities.

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Suggest an Edit → | Last Verified: 2026-04-20 | First Added: 2026-04-20
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