Wolters Kluwer (UpToDate)

Wolters Kluwer, the parent company, is headquartered in Alphen aan den Rijn, the Netherlands. UpToDate, Inc. itself is headquartered in Waltham, Massachusetts, United States.  All United States companies → — Founded 1992
Clinical AI Platform Healthcare Conglomerate Patient Engagement Platform
cardiology-ai dermatology-ai endocrinology-metabolic-ai gastroenterology-ai
Clinical Decision Support & Reference Medical Education & Training
Acquired/Merged (by Wolters Kluwer in 2008)
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About Wolters Kluwer (UpToDate)

Wolters Kluwer (UpToDate) is a leading provider of evidence-based clinical decision support (CDS) solutions for healthcare professionals worldwide. Its flagship product, UpToDate, is a comprehensive software system that offers medical and patient information, drug monographs, drug-to-drug interaction checkers, and medical calculators. Written and reviewed by over 7,600 physician clinical authors, editors, and peer reviewers, UpToDate aims to help clinicians make informed decisions at the point of care, improve quality of care, and enhance patient outcomes.

In response to the evolving healthcare landscape, Wolters Kluwer Health has introduced UpToDate Expert AI, a generative AI-powered clinical decision support solution. This new offering provides fast, reliable, and evidence-based answers to medical questions, grounded in UpToDate’s trusted content. The AI-powered tool is designed to integrate seamlessly into existing healthcare workflows, offering context-rich responses with traceable reasoning and citations to support transparent and governed clinical decision-making. UpToDate is used by over 3 million clinicians in more than 190 countries and is integrated into electronic health record (EHR) systems.

Focus Areas

Clinical Decision Support (CDS) Drug Decision Support Patient and Member Engagement Continuing Medical Education (CME) Healthcare Innovation (including Generative AI) and improving health outcomes and quality of care.

Business Intelligence

TechnologyFoundation and Beyond (FAB) AI enablement platform (model agnostic, enterprise AI enablement platform for model pluralism, agentic orchestration, governance, and scale), Digital eXperience Group (DXG) (reusable platforms and horizontal Centers of Excellence)

What Physicians Need to Know

Clinical Decision Support (CDS)
UpToDate is a leading, evidence-based CDS solution trusted by over 3 million clinicians globally in thousands of hospitals across 190+ countries. It offers over 10,500 peer-reviewed topics across various specialties, including adult primary care, internal medicine, OB/GYN, general surgery, and pediatrics. UpToDate is associated with improved decision-making, quality of care, education, and patient outcomes, including reduced mortality. The platform provides quick and easy access to answers for clinical questions, supporting diagnostic decisions and treatment plans.
Drug Decision Support
Wolters Kluwer offers comprehensive drug decision support through UpToDate Lexidrug (formerly Lexicomp) and Medi-Span. These solutions provide evidence-based, continuously updated drug information to support critical medication and therapeutic decisions, including prescribing, dispensing, and patient counseling. UpToDate Lexidrug content, written and reviewed by pharmacists and clinical specialists, is integrated into UpToDate Expert AI, addressing the nearly 30% of clinician questions that are drug-related.
Patient and Member Engagement
UpToDate Patient Engagement solutions (formerly Emmi) are designed to empower patients to actively participate in their healthcare. These solutions offer vetted, expert-created, and evidence-based content, including patient education materials, to improve care and provide medical education for patients and members. UpToDate has been recognized as #1 Best In KLAS for Patient Education and Patient-Driven Care Management.
Continuing Medical Education (CME)
UpToDate's CME program allows healthcare professionals to earn CME/CE/CPD credits while researching clinical questions at the point of care. This helps clinicians fulfill licensing and Maintenance of Certification/Continuing Certification (MOC/CC) requirements. UpToDate Expert AI now also awards CME credits directly within the workflow, reducing administrative burden. The platform is accredited by various global authorities.
Healthcare Innovation (including Generative AI)
Wolters Kluwer has launched UpToDate Expert AI, a generative AI-powered version of its CDS solution, to provide fast, reliable, and evidence-based answers to clinical questions. UpToDate Expert AI is distinct because its answers are exclusively drawn from UpToDate's expert-authored and peer-reviewed content, aiming to eliminate hallucination. Wolters Kluwer is committed to responsible AI application in healthcare and has introduced AI Labs for collaborative development of new generative AI capabilities. They are integrating UpToDate with Microsoft tools like Dragon Copilot, Microsoft 365 Copilot, and Microsoft Teams to embed clinical intelligence directly into workflows.
Improving Health Outcomes and Quality of Care
UpToDate solutions are proven to improve health outcomes and quality of care, with over 100 research studies supporting its effectiveness. Clinicians report that UpToDate improves the quality of care, helps prevent errors, and saves time. Studies have shown that hospitals using UpToDate experienced better patient outcomes, including shorter hospital stays and reduced mortality rates.
Physician Tip

For physicians, UpToDate offers a comprehensive, continuously updated, and evidence-based resource that acts as a trusted advisor at the point of care. Its unique format and search capabilities allow for quick access to answers for complex clinical questions. The content is written, reviewed, and updated by over 6,500 physicians and experts, ensuring its currency and practical recommendations for diagnosis and treatment. The integration of UpToDate Expert AI provides fast, AI-powered answers grounded in trusted medical knowledge, designed to promote clinical reasoning and provide context-rich responses with transparent sourcing. Physicians can also earn CME credits directly within their workflow using UpToDate Expert AI, streamlining professional development.

Wolters Kluwer (UpToDate) offers robust integration capabilities. UpToDate solutions can be integrated into Electronic Health Record (EHR) systems for faster access within clinical workflows. They also provide UpToDate Connect, a powerful API solution that allows digital health platforms and applications to seamlessly embed trusted UpToDate clinical content directly into their workflows. This enables clinicians to access evidence-based information without switching between tools, minimizing burnout and streamlining workflows. Furthermore, Wolters Kluwer is partnering with Microsoft to integrate UpToDate with Microsoft Dragon Copilot, Microsoft 365 Copilot, and Microsoft Teams, bringing clinical intelligence directly into documentation, communication, and collaboration workflows.

Products by Wolters Kluwer (UpToDate)

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What the Web Says

Wolters Kluwer's UpToDate is a highly regarded clinical decision support tool widely used by healthcare professionals globally. It is praised for its comprehensive, evidence-based content and its utility in clinical practice and education. The company has also recently launched an AI-powered version, UpToDate Expert AI, which is being adopted by a significant number of hospitals. While the product generally receives positive feedback, some users express concerns about its cost and occasional interface issues. As an employer, Wolters Kluwer receives mixed reviews, with some employees highlighting a positive work environment and good benefits, while others point to issues with management, communication, and work-life balance.

Overall: Mixed

Strengths

  • Comprehensive and evidence-based medical content.
  • Easy access to credible information for clinical decision-making.
  • Valuable tool for medical students and residents for learning and staying updated.
  • Continuously updated with the latest medical research and guidelines.
  • Offers CME/CE/CPD credits for users.
  • UpToDate Expert AI provides fast, reliable, and transparent AI-powered answers grounded in vetted content.

Limitations

  • High subscription cost can be a barrier for individuals and smaller clinics.
  • Search functionality can be cluttered.
  • Interface can feel dated and less user-friendly compared to newer alternatives.
  • Process for reviewing and submitting continuing medical education credits can be time-consuming.
  • Some users report issues with management, communication, and work-life balance within the company.
  • Limited offline functionality for some products.

Based on reviews from: G2, Capterra, KLAS Research, Comparably, Indeed.com, Reddit, Software Advice, Fierce Healthcare, Business Wire, Apple App Store, SimplyHired

Last updated: 2026-09-19

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Press & Coverage

Wolters Kluwer
UpToDate Expert AI Reaches 2,500 U.S. Hospitals and Health Systems
Wolters Kluwer announced that its UpToDate Expert AI, which now includes AI-powered drug dosing guidance, has been adopted by approximately 2,500 U.S. hospitals and health systems, representing over 90% of its U.S. UpToDate Enterprise Edition customers. The solution provides evidence-based dosing recommendations and supports safe, consistent decision-making.
2026-08
Wolters Kluwer
New Wolters Kluwer Health prior authorization and claims processing optimization tools help payers meet tighter regulatory timelines, reduce high appeal overturn rates
Wolters Kluwer Health has released new tools designed to optimize prior authorization and claims processing for payers, aiming to help them meet stricter regulatory timelines and decrease high appeal overturn rates. These features assist payer teams in interpreting clinical intent more consistently across authorization and claims workflows.
2026-08
Wolters Kluwer
Wolters Kluwer brings trusted Medi-Span medication intelligence to growing veterinary drug market
Wolters Kluwer is expanding its Medi-Span medication intelligence to the veterinary drug market, driven by a survey indicating that three out of four pet owners desire to get pet prescriptions from their retail pharmacies. This move creates new growth opportunities for pharmacies and pharmacy technology providers.
2026-08
Wolters Kluwer
Wolters Kluwer to help rural hospitals and FQHCs access top drug information and patient education solutions integrated with Epic
Wolters Kluwer will provide rural hospitals and Federally Qualified Health Centers (FQHCs) with turnkey access to UpToDate Lexidrug, Medi-Span, and UpToDate Patient Education solutions, integrated with Epic. This initiative aims to enhance access to crucial drug information and patient education for these healthcare providers.
2026-07
Wolters Kluwer
How UpToDate and Epic are collaborating to streamline clinicians' workflows to help transform patient care
UpToDate and Epic are collaborating to embed trusted clinical intelligence and evidence-based guidance directly into Epic's workflows, including the Epic Agent Factory. This integration aims to streamline clinicians' workflows, support faster care decisions, and enable health systems to build AI experiences on strong clinical foundations.
2026-09
Wolters Kluwer
Wolters Kluwer partners with Microsoft to bring trusted clinical intelligence to Microsoft productivity workflows
Wolters Kluwer Health announced a partnership with Microsoft to integrate UpToDate with Microsoft Dragon Copilot, Microsoft 365 Copilot, and Microsoft Teams. This collaboration allows clinicians to access evidence-based clinical intelligence directly within their documentation, communication, and collaboration tools.
2026-03
Wolters Kluwer
Wolters Kluwer UpToDate Expert AI now awards Continuing Medical Education (CME) Credits
Wolters Kluwer Health announced that clinicians using UpToDate Expert AI can now earn Continuing Medical Education (CME) credit directly within their clinical workflow. This integration aims to reduce the administrative burden of professional development and support continuous learning in real-world clinical settings.
2026-03
Wolters Kluwer
Wolters Kluwer helps digital health platforms seamlessly embed trusted clinical content with new UpToDate Connect
Wolters Kluwer Health launched UpToDate Connect, an API solution enabling digital health tech companies to embed trusted clinical content into their applications and platforms. This streamlines workflows, provides fast and reliable answers at the point of care, and helps minimize clinician burnout.
2025-10

Frequently Asked Questions

Wolters Kluwer (UpToDate) maintains a rigorous editorial process with over 50 in-house physician deputy editors and 7,400 world-renowned experts who systematically identify, review, and synthesize new clinical evidence. Their Generative AI solution, UpToDate Expert AI, is exclusively grounded in this expert-authored and peer-reviewed content, preventing the incorporation of information from the open web to eliminate the risk of 'hallucinations' and ensure trustworthy, evidence-based insights at the point of care.
Wolters Kluwer offers UpToDate Patient and Member Engagement solutions (formerly Emmiu00ae) which provide interactive educational programs to help patients understand complex medical information, prepare for procedures, and manage chronic conditions. These programs are designed to answer frequently asked questions and can be accessed from home, aiming to improve patient understanding, adherence, and ultimately, health outcomes.
UpToDate allows healthcare professionals to earn CME/CE/CPD credits while researching clinical questions within the platform. These credits are recognized by various accrediting organizations globally, and users can easily track, manage, and redeem them for up to two years. UpToDate also offers direct credit submission to all state medical boards via CME Passport, simplifying compliance for licensed physicians.
Wolters Kluwer has introduced UpToDate Expert AI, a generative AI-powered CDS solution designed to provide fast, reliable answers to clinical questions. Their strategy focuses on grounding the AI exclusively in their expert-authored, peer-reviewed UpToDate content, ensuring accuracy and eliminating hallucinations. The system is built with transparent reasoning, providing context-rich responses with single-click access to sources and rationale to support clinical judgment.
UpToDate solutions are designed to improve health outcomes and quality of care by providing clinicians with trusted, evidence-based information at the point of care, which helps in making informed decisions, preventing errors, and saving time. Research indicates that hospitals utilizing UpToDate have seen improved patient outcomes, including shorter hospital stays and reduced mortality rates. The UpToDate Enterprise Suite aims to unify care teams and standardize care quality across organizations.
Wolters Kluwer (UpToDate) offers various subscription options, including individual annual subscriptions with a 30-day money-back guarantee, and discounts for students/trainees and group practices of 2 to 19 individuals. For larger healthcare systems, an Enterprise sales team can provide information on subscription options for 20 or more users. Support is available through a knowledge base, FAQs, and training videos covering features, CME, and mobile app usage.
While the provided search results don't explicitly detail specific partnership names beyond internal product integrations like UpToDate Lexidrug (formerly Lexicomp) and Medi-Span, Wolters Kluwer emphasizes integrating its reliable, evidence-based content into clinical workflows. This suggests a focus on interoperability with Electronic Health Records (EHRs) and other healthcare technologies to support informed decision-making across the healthcare ecosystem.

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