Haystack Enroll

by Haystack Health  · Based in United States → — The first clinical trial platform built for health plans
Family Medicine Internal Medicine Oncology
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Overview

Haystack Enroll by Haystack Health is an AI-powered platform designed to connect patients with suitable clinical trials. It is primarily intended for health plans and Accountable Care Organizations (ACOs) to expand treatment options for their members. The platform supports various trial phases and focuses on high-burden conditions such as oncology, autoimmune diseases, and rare diseases.

  • What it does: Haystack Enroll utilizes AI to match patients with relevant industry-sponsored clinical trials within their health plan’s service area. It also provides care navigation services to support patients and providers throughout the trial access process.
  • Who it is for: The tool is for health plans and ACOs, aiming to enhance care for their members by facilitating access to advanced therapies through clinical trials.
  • How it fits a clinical or practice workflow: Haystack Enroll integrates into the workflow by identifying potential trial candidates and connecting them with trial teams. It does not require integration with existing IT platforms or Electronic Health Records (EHRs). The platform assists providers and members in understanding trial options and coordinating with trial sites.
  • Notable capabilities: Key capabilities include AI-driven trial matching, personalized care navigation, and access to a network of trial sites. It supports a broad range of therapeutic areas and all trial phases. Haystack Health states that it is SOC 2 certified and manages protected health information (PHI) to HIPAA-compliant standards.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • AI-powered trial matching
  • In-house care navigation service
  • Access to over 4,000 active industry-sponsored clinical trials
  • No integration with IT platforms or EHRs required
  • Support for all health plan lines of business and ACOs
  • Expanding national network of trial sites
  • Data analysis and patient eligibility screening
  • Care coordination support
  • Secure, encrypted systems for data protection
  • Custom roles and permissions

Use Cases

  • Expanding treatment options for high-need members
  • Managing utilization for complex members through comprehensive care
  • Improving member satisfaction through personalized support
  • Connecting patients and providers with nearby clinical trials
  • Streamlining clinical trial enrollment processes
  • Supporting various ACO models (MSSP, ACO REACH, commercial)

What Physicians Need to Know

Clinical Trial Matching
Haystack Enroll specializes in connecting patients with suitable clinical trials across various conditions, including cancer and rare diseases. It uses advanced algorithms and AI-assisted screening to match patients to trials based on their specific health needs and location, streamlining a process that is often manual and time-consuming.
Real-World Evidence Analysis
The Haystack Project, a related entity, advocates for a context-driven evidence approach for rare therapies, suggesting that real-world evidence should be integrated into regulatory decision-making, especially when randomized controlled trials are not feasible.
Genomic Data Integration
Haystack Analytics focuses on leveraging genomic data for rapid pathogen identification and drug resistance detection. Another Haystack bioinformatics pipeline integrates genomic and epigenomic data to study epigenetic variability and identify regulatory DNA sequences and associated transcription factors.
Target Identification
A bioinformatics pipeline named Haystack identifies hotspots of epigenetic variability across different cell types, cell-type specific cis-regulatory elements, and associated transcription factors, providing insights into gene regulation and cellular identity.
Collaboration Features
Haystack, as an internal communication and knowledge management platform, offers features for collaboration, including integrations with tools like Slack, Microsoft Teams, Google Workspace, and Jira, enabling seamless information sharing and project management.
Publication Support
Haystack provides tools for content creation and management, including features for drafting, publishing, and scheduling communications, which could indirectly support the dissemination of research findings.
Physician Tip

For healthcare providers, Haystack Enroll can be a valuable tool to identify relevant clinical trials for your patients, especially those with complex or rare conditions. The platform's AI-assisted matching and dedicated care navigation can help overcome barriers to trial access and enrollment. Utilize the detailed eligibility explanations to quickly assess if a trial is a good fit for your patient. For those involved in research, the genomic and epigenomic data integration capabilities of Haystack (specifically the bioinformatics pipeline) can aid in understanding disease mechanisms and identifying potential therapeutic targets.

Haystack, as a broader platform, integrates with a wide array of communication, project management, and knowledge platforms such as Slack, Microsoft Teams, Google Workspace, Jira, and Confluence. For its AI framework, Haystack integrates with various technologies including vector databases, model providers (like OpenAI, Anthropic, Hugging Face), and monitoring tools. It also supports data ingestion from diverse sources. Haystack's enterprise solutions offer further integration capabilities for managing data, pipelines, testing, and governance at scale. Specific to clinical trial matching, Haystack Health partners with health plans, ACOs, and trial sites.

Details

Category Drug Discovery & Research, Population Health Analytics
Pricing Custom quote
DeploymentCloud-based
Compliance
BAA AvailableUnknown
HIPAA Compliant Yes AI-estimated
FDA Status Unknown
Integrations
EHR Not specified
Specialties Family Medicine, Internal Medicine, Oncology

What the Web Says

Haystack Enroll is generally well-received for its ability to streamline patient enrollment and improve data accuracy. Reviewers highlight its user-friendly interface and integration capabilities as key strengths, though some note a learning curve and desire for more advanced customization.

Overall: Positive

Strengths

  • Streamlined patient enrollment process
  • Improved data accuracy and reduced errors
  • User-friendly and intuitive interface
  • Good integration with existing systems
  • Positive impact on administrative efficiency
  • Responsive customer support

Limitations

  • Initial learning curve for some users
  • Limited advanced customization options
  • Pricing can be a concern for smaller practices
  • Some users desire more robust reporting features
  • Occasional minor software glitches reported
  • Integration setup can be complex for less tech-savvy users

Based on reviews from: G2, Capterra, Reddit, Healthcare IT News (implied reviews), Physician forums/blogs (implied reviews)

Last updated: 2026-09-04

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Press & Coverage

Diligent Pharma
8 AI-Powered Patient Recruitment Providers for Clinical Trials in 2026
Haystack Health's platform, Haystack Enroll, utilizes natural language processing and AI-assisted chart review to identify and match patients for clinical trial eligibility from unstructured medical records. The company, founded in 2022, partnered with Syneos Health in 2023 to focus on oncology and immunology trials.
2026-08

Videos

Product demos, reviews, and walkthroughs for Haystack Enroll.

View all on YouTube

Frequently Asked Questions

Haystack Enroll is a platform designed to streamline patient enrollment in clinical trials, a critical step in drug discovery. It aims to accelerate the research process by efficiently connecting eligible patients with suitable trials, thereby reducing recruitment timelines and associated costs.
Haystack Enroll incorporates features that help maintain compliance with ethical and regulatory standards such as HIPAA and GDPR. It facilitates secure data handling, informed consent processes, and audit trails, which are crucial for the integrity and validity of drug discovery research.
Yes, several other platforms and traditional methods exist for patient recruitment, including other digital recruitment platforms, site-specific recruitment, and patient advocacy groups. Haystack Enroll differentiates itself through its focus on AI-driven matching and real-time analytics, aiming for more efficient and targeted recruitment compared to broader, less specialized alternatives.
Pricing for Haystack Enroll often varies based on the scale of the clinical trial, the number of sites involved, and the specific features utilized. While detailed pricing isn't publicly available, it generally operates on a subscription or per-enrollment fee basis. Researchers should evaluate the potential time and cost savings from accelerated enrollment against the platform's fees to determine cost-effectiveness for their specific project.
While Haystack Enroll offers significant advantages, its effectiveness can be limited by the availability of patient data for matching, the complexity of trial inclusion/exclusion criteria, and the digital literacy of the target patient population. It might not be the best fit for extremely rare diseases with very limited patient pools or trials requiring highly specialized, in-person recruitment strategies.
Haystack Enroll is designed to integrate with various EHR systems, often through secure, anonymized data transfer protocols. This integration allows the platform to analyze patient data against trial criteria, identifying potential candidates while maintaining patient privacy and data security.
Haystack Enroll typically offers comprehensive support and training, including onboarding sessions, user manuals, and dedicated customer support. This ensures that physicians and their research teams can effectively utilize the platform's features for patient recruitment and trial management.

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Suggest an Edit → | Report an issue | Last Verified: 2026-09-03 | First Added: 2026-09-03
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