Haystack Health

New York, NY, United States [1]  All United States companies → — Founded 2019 [1]
Biotech / Drug Discovery Clinical AI Platform Healthcare Analytics / BI
Family Medicine Internal Medicine Oncology
Drug Discovery & Research Population Health Analytics
Accelerator/Incubator Backed [1]
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Products

Haystack Enroll
Haystack Health
Drug Discovery & Research
Haystack Health is a clinical trial platform that utilizes AI and care navigation to connect health plan members and ACO patients with relevant clinical trials, aiming to expand treatment access and improve outcomes.
Custom quote

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About Haystack Health

Haystack Health is a healthcare AI company that operates a digital platform focused on clinical trial matching and patient identification. The company aims to revolutionize patient recruitment by addressing trial delays and reducing the burden on research sites through cutting-edge AI technology and clinical solution services. [8] Their platform provides data analysis, patient eligibility screening, trial matching algorithms, care coordination support, and integration with healthcare systems. [1]

Haystack Health’s mission is to expand access to life-changing clinical research for all individuals, regardless of their health plan, location, or background. [4] They partner with health plans (including Medicare Advantage, employer-sponsored, marketplace, and Medicaid), Accountable Care Organizations (ACOs), and value-based care partners to bring clinical trial access directly to members and patients. [4] The platform supports all trial phases, with a particular focus on high-burden conditions such as oncology, autoimmune diseases, rare diseases, diabetes, obesity, inflammatory bowel disease (IBD), and cardiovascular and neurological conditions. [4, 10] Haystack Health emphasizes patient privacy and is SOC 2 certified, managing all Protected Health Information (PHI) to HIPAA-compliant standards. [4, 7]

Focus Areas

AI-driven clinical trial matching care navigation clinical research access chronic disease management oncology autoimmune diseases rare diseases digital health SaaS HealthTech

Business Intelligence

TechnologyAI-driven trial matching platform, cloud-native, HIPAA compliant, SOC 2 certified

What Physicians Need to Know

AI-Driven Clinical Trial Matching
Haystack Health utilizes advanced AI algorithms to dynamically match patients to suitable clinical trials in real-time, leveraging both structured and unstructured clinical data. This includes using Large Language Models (LLMs) like fine-tuned Llama 3.1 8B LLM-OncoLlama for complex cancer data extraction from free text, identifying cancer facts, treatment timelines, and patient facts.
Care Navigation & Clinical Research Access
The company provides end-to-end clinical trial solutions, combining AI-driven matching with personalized care navigation and a national research access network. They support members and providers in understanding and accessing matched clinical trials, enhancing treatment options and managing utilization.
Chronic Disease Management
Haystack Health supports various high-burden conditions, including diabetes and obesity, IBD, and cardiovascular disease, by connecting patients to relevant clinical trials.
Oncology
A significant focus is placed on oncology, where their AI-powered platform extracts detailed cancer facts, treatment timelines, and patient information to precisely identify patients for trials. Haystack Health also supports all phases of oncology trials.
Autoimmune Diseases
Haystack Health expands access to clinical trials for autoimmune diseases. There is also research into using a 'Haystack Heuristic' algorithm for autoimmune disease biomarker discovery from immune repertoire sequencing data.
Rare Diseases
The company is committed to expanding access to trials for rare diseases. The 'Haystack Project' is a non-profit enabling rare and ultra-rare disease patient advocacy organizations to address systemic obstacles to patient access and shape healthcare policies.
Digital Health & HealthTech
Haystack Health operates a digital platform for clinical trial matching and patient identification, providing data analysis, patient eligibility screening, trial matching algorithms, and care coordination support. They are transforming clinical trial access to be more accessible, compassionate, and affordable.
SaaS
Haystack Health offers its AI-driven clinical trial platform as a Software-as-a-Service (SaaS) solution, purpose-built for health plans and Accountable Care Organizations (ACOs).
Physician Tip

Haystack Health offers physicians a powerful tool to enhance patient care by providing access to a broad network of clinical trials, particularly for complex and high-burden conditions like oncology, autoimmune, and rare diseases. The AI-powered matching platform, combined with dedicated care navigation, streamlines the process of identifying eligible patients and connecting them with trial sites. This can expand treatment options for patients, potentially improve outcomes, and manage utilization. The platform requires no integration with existing IT platforms or Electronic Health Records (EHRs), making it easy to adopt. Physicians retain all care decisions, ensuring appropriate care for their patients.

Haystack Health's primary clinical trial matching platform is designed to be used without requiring integration with existing IT platforms or Electronic Health Records (EHRs). However, a separate product, Haystack iS (by iatricSystems), which focuses on patient privacy monitoring, does integrate with over 800 vendors, including major EHR systems like Epic, Cerner, MEDITECH, Allscripts, Athena, as well as document management, clinical, and HR systems.

Products by Haystack Health

1 product in the directory

Haystack Enroll
Haystack Health
Drug Discovery & Research
Haystack Health is a clinical trial platform that utilizes AI and care navigation to connect health plan members and ACO patients with relevant clinical trials, aiming to expand treatment access and improve outcomes.
Custom quote

What the Web Says

Haystack Health appears to be a company offering an intranet solution focused on employee engagement and productivity, leveraging AI and seamless integrations. It is also associated with digital business cards and, in some contexts, a tech careers marketplace. Reviews indicate that the product is generally well-received for its user-friendliness and ability to centralize communication and resources. However, there are some criticisms regarding customer service and search functionality. Employer reviews are mixed, with some positive experiences regarding flexibility and management, while others express concerns about work environment and pay.

Overall: Mixed

Strengths

  • Ease of use and intuitive design.
  • Effective centralization of communication and resources.
  • AI-powered search capabilities.
  • Seamless integrations with other tools.
  • Good for employee engagement and productivity.
  • Flexible work hours and competitive pay (employer review).

Limitations

  • Customer service can be poor or unresponsive.
  • Search functionality can be challenging to use.
  • Loading times can be slow.
  • Lack of sorting options makes page design cumbersome.
  • Multi-step login process can be frustrating.
  • Concerns about work environment and pay (employer review).

Based on reviews from: Capterra, G2, Indeed.com, Reddit

Last updated: 2026-09-04

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Press & Coverage

Haystack MRDu00ae
Haystack MRDu00ae receives New York State approval
The New York State Department of Health (NYSDOH) Clinical Laboratory Evaluation Program (CLEP) has approved Haystack MRDu00ae for identifying residual or recurring disease in solid tumor cancer patients. This approval expands access to the test for select providers via OncoEMR MPI capability.
2026-06
Consumer connect News (Business Standard)
HaystackAnalytics brings most cutting-edge technology to close diagnostic gap in infectious diseases
HaystackAnalytics is expanding its network of Genomic Centers of Excellence across India to make advanced genomics-based diagnostics for infectious diseases more accessible, aiming for 100 centers within the next year. This initiative seeks to overcome delays and complexities in current diagnostic methods by bringing advanced sequencing technologies closer to treatment centers.
2026-08
The Haystack Project
Haystack Project Files Petition for Rulemaking to Establish Context-Based Evidence Framework for Rare Diseases
The Haystack Project, a rare disease advocacy group, has formally petitioned the FDA to adopt a context-driven evidence approach for evaluating therapies for small patient populations. This framework would align study design, endpoints, and analytical methods with disease characteristics and incorporate disease-specific expert input.
2026-04
BioSpace
FDA Grants Breakthrough Device Designation for Haystack MRD Circulating Tumor DNA Test from Quest Diagnostics
The FDA granted Breakthrough Device Designation for Quest Diagnostics' Haystack MRDu00ae test for identifying MRD-positive patients with stage II colorectal cancer who may benefit from adjuvant therapy. This designation highlights the test's potential to detect residual or recurrent cancer earlier than other methods.
2025-08
PR Newswire
Haystack Oncology Launches with $56 Million in Series A Financing to Accelerate Adoption of Post-Op Cancer Detection Technology and Optimize Cancer Therapy Monitoring and Treatment
Haystack Oncology launched with $56 million in Series A financing to develop and commercialize its highly sensitive circulating tumor DNA (ctDNA) detection technology for minimal residual disease (MRD) testing in solid tumors. The funding will support the planned 2023 commercialization of its personalized cancer diagnostic test.
2022-11
PR Newswire
Quest Diagnostics to Acquire Haystack Oncology, Adding Sensitive Liquid Biopsy Technology for Improving Personalized Cancer Care to Oncology Portfolio
Quest Diagnostics announced its acquisition of Haystack Oncology, integrating Haystack's ctDNA-based technology for MRD detection into Quest's oncology portfolio. This acquisition aims to enhance personalized cancer care with new clinical lab services for colorectal, breast, and lung cancers.
2023-04
Haystack Health
Haystack Health - Clinical Trial Platform for Health Plans and ACOs
Haystack Health offers an AI-powered clinical trial platform designed for health plans and ACOs, connecting patients and providers with suitable clinical trials. The platform focuses on expanding access to trials for various conditions, including oncology, autoimmune diseases, and rare diseases, while ensuring HIPAA compliance.
unknown
Bioinformatics (PMC)
Haystack: systematic analysis of the variation of epigenetic states and cell-type specific regulatory elements
This peer-reviewed article introduces 'Haystack,' a bioinformatics pipeline for systematically analyzing epigenetic states and cell-type specific regulatory elements. The tool helps identify hotspots of epigenetic variability and associated transcription factors, offering a valuable resource for functional annotation of the human genome.
2018-01

Frequently Asked Questions

Haystack Health leverages AI and machine learning to analyze vast amounts of patient data, including electronic health records, to identify eligible patients for clinical trials with high precision. This accelerates the matching process, reduces manual effort, and ultimately expands access to cutting-back-edge research for patients who might otherwise be overlooked.
Haystack Health's platform is designed for seamless integration with most major EHR systems through secure APIs, minimizing disruption to existing workflows. The company prioritizes data security and is fully compliant with HIPAA, GDPR, and other relevant healthcare data regulations, employing robust encryption and access controls to protect sensitive patient information.
Yes, Haystack Health's solutions are highly customizable. The AI models can be tailored to specific patient populations and disease states, allowing healthcare providers to optimize care navigation and chronic disease management strategies for complex areas like oncology, autoimmune diseases, and rare diseases, leading to more personalized and effective interventions.
Haystack Health typically offers a subscription-based SaaS model, with pricing often dependent on the scale of deployment and specific modules utilized. They provide comprehensive support, including initial implementation, ongoing technical assistance, and training for clinical and administrative staff to ensure effective adoption and utilization of the platform.
Haystack Health is committed to advancing digital health through AI-driven solutions, with a long-term vision of revolutionizing patient care and research access. While specific partnerships may vary, the company actively seeks collaborations with leading healthcare institutions and technology providers to strengthen its market position and expand its impact.

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