Cleerly
Overview
Cleerly is an FDA-cleared, cloud-based digital health platform that utilizes machine learning and advanced image analysis to evaluate coronary computed tomography angiography (CCTA) scans. Moving beyond traditional luminal stenosis grading and coronary artery calcium (CAC) scoring, Cleerly identifies, characterizes, and quantifies atherosclerosis at the individual vessel and whole-heart level.
The platform delivers precise measurements of total plaque volume, plaque composition (such as low-attenuation, fibrofatty, fibrous, and calcified plaque), and vascular morphology. Through its advanced analytics suite—including Cleerly Plaque Analysis, Cleerly ISCHEMIA, and Cleerly COMPARE—clinicians can identify high-risk non-calcified plaque, evaluate vessel-specific ischemia non-invasively, and track disease progression or regression over serial imaging studies.
Validated in major prospective clinical trials such as CREDENCE and PACIFIC, Cleerly equips cardiologists, radiologists, and primary care physicians with actionable, standardized reporting. By identifying patient-specific plaque phenotypes before adverse cardiac events occur, clinicians can optimize preventative pharmacotherapy and reduce unnecessary invasive coronary angiographies.
Reviewed by Pouyan Golshani, MD — Interventional Radiologist
Key Features
- Automated whole-heart coronary artery segmentation and lumen centerline extraction
- Quantification of total atheroma volume and percent atheroma volume (PAV)
- Plaque characterization into low-attenuation plaque (LAP), fibrofatty, fibrous, and calcified tissue
- Cleerly ISCHEMIA non-invasive vessel-specific ischemia prediction
- Cleerly COMPARE serial scan tracking to monitor plaque progression or regression under therapy
- 2D and 3D stenosis severity measurement across all major epicardial coronary vessels
- CAD-RADS 2.0 aligned reporting with high-risk plaque feature flags
- Direct PACS, cloud DICOM routing, and EHR-compatible report export
Use Cases
- Evaluating symptomatic stable chest pain patients presenting for outpatient CCTA
- Identifying high-risk non-calcified plaque vulnerable to rupture in early-stage CAD
- Non-invasive physiological assessment of coronary stenosis to reduce diagnostic invasive angiograms
- Monitoring patient response and plaque regression during intensive lipid-lowering medical therapy
- Cardiovascular risk stratification in asymptomatic patients with elevated risk factors
What Physicians Need to Know
Cleerly provides quantitative measurements of plaque, stenosis, and likelihood of ischemia, offering a comprehensive view of coronary artery disease. This can help in personalizing therapy and monitoring plans, especially for patients with risk factors but no known CAD, those with borderline calcium scores, or for serial monitoring to track plaque changes over time. The detailed reports and interactive web platform can aid in patient education and engagement. Consider a baseline Cleerly scan in the early 50s for average-risk individuals, and sooner for those with a family history or concerning markers. Follow-up scans can be tailored based on disease severity.
Cleerly integrates with radiology reporting solutions like Nuance PowerScribe (360 and One) via API, sending analysis results directly into CCTA reports. CCTA uploads for Cleerly analysis can be done through direct upload, the Nuance Powershare network, Intelerad Inteleshare, and Cleerly Proxy, a cloud-based solution that integrates into existing hospital and practice workflows. Cleerly also partners with organizations like Cardiac Care Alliance to integrate its AI-powered coronary artery assessment technology into cardiovascular care networks. As of January 2026, AI plaque analysis has its own Medicare billing code (CPT 75577), and private insurers covering over 86 million Americans now cover it.
Details
| Category | Cardiology AI, Clinical Decision Support & Reference, Radiology & Imaging AI |
| Pricing | Varies |
| Deployment | Cloud, On-premise (virtual appliance) |
| Compliance | |
| BAA Available | Yes AI-estimated |
| HIPAA Compliant | Yes AI-estimated |
| FDA Status | Cleared AI-estimated |
| SOC 2 | Yes AI-estimated |
| Integrations | |
| EHR | Cerner, Epic |
| Specialties | Cardiology, Internal Medicine, Preventive Medicine, Radiology |
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Press & Coverage
Videos
Product demos, reviews, and walkthroughs for Cleerly.
Cleerly ISCHEMIA --- Ischemia. Reinvented.
Cleerly
Cleerly Uses An AI-Based Digital Platform to Transform the Treatment of Heart Disease
DocWire
Cleerly sponsored webinar | An End-to-End AI Solution for Precision Heart Care
Society of Cardiovascular Computed Tomography
Why We Retracted the Cleerly Paper
Dave Feldman
Cleerly Symposium | Plaque evolution: How AI & serial scanning can change the game
Society of Cardiovascular Computed Tomography
Are the Cleerly CT scans really accurate? Can they detect soft plaque? How accurate are the AI CT
Dr Alo
Frequently Asked Questions
Investors who backed Cleerly
Funded through the company that built this tool.
