HeartFlow Analysis vs prolaio eVO2peak Module

Similar category, different focus. These tools serve overlapping but distinct needs. Comparability 65/100 Comparability is an AI-graded 0–100 score of how directly these two tools compete — higher means a more apples-to-apples comparison.
by HeartFlow
VS
by Prolaio

AI Verdict

HeartFlow Analysis provides detailed non-invasive diagnostic insights into coronary artery disease using CT scans, focusing on arterial anatomy and blood flow. In contrast, Prolaio's eVO2peak Module estimates overall cardiorespiratory fitness from wearable sensor data, offering a functional assessment for broader cardiovascular care and research. Therefore, HeartFlow is suited for specific CAD diagnosis and management, while Prolaio is for assessing general cardiovascular capacity and prognosis.

Choose HeartFlow Analysis if…

Choose HeartFlow Analysis if you require a highly accurate, non-invasive diagnostic assessment of coronary artery disease (CAD) based on standard CT scans. This tool is ideal for clinicians seeking detailed insights into coronary artery blockages, their functional impact (FFRct), and plaque characteristics to guide treatment decisions. It provides personalized 3D models and computational fluid dynamics for a comprehensive understanding of a patient's coronary health.

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Choose prolaio eVO2peak Module if…

Choose prolaio eVO2peak Module if you need to estimate peak oxygen consumption (eVO2peak) using real-world patient data from wearable sensors for ongoing cardiovascular assessment or research. This software is best suited for clinicians and researchers looking for a non-invasive, longitudinal method to track cardiorespiratory fitness, especially in specialties like physical medicine, rehabilitation, or sports medicine, by processing data from qualified third-party FDA-cleared wearable medical sensors.

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Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Quick Comparison

Feature HeartFlow Analysis prolaio eVO2peak Module
Pricing Contact vendor for pricing Contact for pricing
Deployment Cloud-based (AWS) Cloud-based (software-only, processes remote sensor data)
BAA Available Yes AI-estimated Yes AI-estimated
FDA Status Yes AI-estimated Cleared AI-estimated
HIPAA Yes AI-estimated Yes AI-estimated

Feature-by-Feature

Detail beyond the Quick Comparison summary. For pricing, deployment, BAA, FDA, and HIPAA see the Overview tab.

Feature HeartFlow Analysis prolaio eVO2peak Module
Name HeartFlow Analysis prolaio eVO2peak Module
Company HeartFlow Prolaio
Description Commercial-stage medical technology company providing software and artificial intelligence (AI) designed to deliver a non-invasive solution for diagnosing and managing coronary artery disease (CAD) by creating personalized 3D models of patients' coronary arteries from standard CT scans. A clinical intelligence company that develops FDA-cleared software, such as the eVO2peak Module, to estimate peak oxygen consumption using real-world patient data for cardiovascular research and care.
Tagline Decisive Coronary Care Heart care, connected.
Key Features AI-powered 3D modeling of coronary arteries, Fractional Flow Reserve derived from CT (FFRct) analysis, Plaque Analysis (quantification and characterization), Roadmapu2122 Analysis for CCTA reading, Non-invasive diagnostic assessment, Personalized patient insights, Computational Fluid Dynamics (CFD) for blood flow simulation, High diagnostic accuracy Estimates peak oxygen consumption (eVO2peak), Utilizes demographic data, single-lead ECG, and triaxial accelerometry inputs, Processes data from qualified third-party FDA-cleared wearable medical sensors, Applies a locked deep-learning model for eVO2peak estimation, Provides information as an adjunctive aid in clinical evaluation, Enables high-density, longitudinal data collection, Leverages real-world patient data and insights, Features FDA-cleared software and proprietary algorithms

Videos

Demos, reviews, and walkthroughs featuring HeartFlow Analysis and prolaio eVO2peak Module.

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Frequently Asked Questions

HeartFlow Analysis is designed for the non-invasive diagnosis and management of coronary artery disease (CAD) by creating personalized 3D models of coronary arteries, including Fractional Flow Reserve derived from CT (FFRct) and Plaque Analysis. In contrast, the Prolaio eVO2peak Module estimates peak oxygen consumption (eVO2peak) using real-world patient data, serving as an adjunctive aid in cardiovascular research and care.
HeartFlow Analysis utilizes data from standard CT scans to generate its insights. The Prolaio eVO2peak Module processes demographic data, single-lead ECG, and triaxial accelerometry inputs obtained from qualified third-party FDA-cleared wearable medical sensors.
HeartFlow Analysis provides AI-powered 3D modeling of coronary arteries, FFRct analysis, and plaque quantification and characterization. The Prolaio eVO2peak Module delivers an estimation of peak oxygen consumption (eVO2peak).
HeartFlow Analysis has established Category I CPT codes for FFRct Analysis (75580) and AI-Enabled Quantitative Plaque Analysis (75577 for 2026), with coverage by Medicare and most U.S. commercial payers and established CMS payment rates. For the Prolaio eVO2peak Module, physicians need to contact the vendor directly for pricing information.
HeartFlow Analysis is primarily intended for Cardiology and Radiology specialties. The Prolaio eVO2peak Module is designed for Cardiology, Physical Medicine & Rehab, and Sports Medicine.
HeartFlow Analysis uses AI to create personalized 3D models of coronary arteries, perform FFRct analysis, and quantify plaque from CT scans. The Prolaio eVO2peak Module applies a locked deep-learning model to estimate eVO2peak from collected wearable sensor data and demographic inputs.

Backers

Who funded each tool's parent company.

HeartFlow Analysis

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