DETECT-ME/CFS project (ME/CFS Research Foundation)

Hamburg, Germany  All Germany companies → Founded 2022
Non-profit organization, primarily donation-funded — €2.4 million for 2026 research program (increased from €2 million due to donations); approximately €823,000 in donations acquired from early 2022 to end of 2023.

Products

DETECT-ME/CFS project
DETECT-ME/CFS project (ME/CFS Research Foundation)
Clinical Decision Support & Reference
The DETECT-ME/CFS project is developing an AI-supported clinical decision support system to improve the rapid and reliable diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

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About DETECT-ME/CFS project (ME/CFS Research Foundation)

The DETECT-ME/CFS project, an initiative of the ME/CFS Research Foundation, is a healthcare AI company focused on revolutionizing the diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). ME/CFS is a severe, chronic multi-system disease characterized by symptoms such as post-exertional malaise (PEM), pain, cognitive dysfunction, and sleep disturbances, often leading to significant impairment in daily functioning. The project aims to address the current challenges in ME/CFS diagnosis, including limited resources in specialized facilities and the lack of reliable biomarkers, by developing an innovative clinical decision support system (CDSS) powered by artificial intelligence (AI).

This AI-driven CDSS is designed to enhance diagnostic accuracy and efficiency. It achieves this by analyzing anonymized patient data to identify patterns and novel diagnostic features, thereby aiding in the reliable exclusion of differential diagnoses. Furthermore, the system incorporates automated literature searches for ME/CFS and established differential diagnoses, leveraging machine learning to improve overall diagnostic capabilities. The DETECT-ME/CFS project envisions that a successful implementation of this AI-based support system will significantly improve diagnostic processes in routine clinical practice, conserve essential healthcare resources, and alleviate the burden on specialized outpatient clinics. In the long term, this model holds potential for broader application in the clinical diagnosis of other complex diseases, marking a significant advancement in healthcare.

Focus Areas

ME/CFS diagnosis AI-powered clinical decision support systems biomarker identification machine learning for medical literature differential diagnosis healthcare resource optimization

Business Intelligence

Key InvestorsFederal Ministry of Health (Bundesministerium für Gesundheit), EU Horizon Europe program, ME/CFS Research Foundation
PartnershipsCharité - Universitätsmedizin Berlin, Helmholtz-Zentrum für Infektionsforschung GmbH Braunschweig
TechnologyClinical Decision Support System (CDSS) with Artificial Intelligence (AI) for analyzing anonymized patient data and automated literature search using machine learning.

What Physicians Need to Know

ME/CFS Diagnosis & Screening
The DETECT-ME/CFS project is developing an innovative Clinical Decision Support System (CDSS) to improve the screening and diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). This aims to reduce the burden on specialized clinics and enable timely patient care.
AI-Powered Clinical Decision Support
Their CDSS integrates clinical expertise and diagnostic decision-making processes into computer-based algorithms. It uses AI-based analyses of patient databases to identify patterns and novel diagnostic features, aiding in the differentiation and exclusion of other diagnoses.
Biomarker Identification
The project focuses on identifying reliable biomarkers for ME/CFS, which are currently lacking. This includes analyzing anonymized patient data to uncover new diagnostic features.
Machine Learning for Medical Literature
A symptom-disease association model is being developed based on automated literature mining of ME/CFS and related differential diagnoses to strengthen diagnostic capabilities.
Differential Diagnosis
The AI-based analyses of patient databases are designed to support the differentiation and exclusion of various differential diagnoses, which is crucial given the complex and often overlapping symptoms of ME/CFS.
Healthcare Resource Optimization
By improving screening and diagnosis, the project aims to reduce the burden on specialized ME/CFS clinics with limited resources, thereby optimizing healthcare delivery.
Physician Tip

The DETECT-ME/CFS project offers physicians a powerful AI-driven tool to enhance ME/CFS diagnosis, potentially reducing diagnostic delays and improving patient outcomes. The system's ability to analyze patient data and medical literature can assist in differentiating ME/CFS from other conditions, providing more confident diagnoses. This can be particularly beneficial for a disease that has historically been challenging to confirm due to a lack of definitive tests and overlapping symptoms. The project's focus on identifying biomarkers and integrating clinical expertise into its algorithms means that physicians can expect a more objective and efficient diagnostic process, potentially leading to earlier and more appropriate patient care.

The DETECT-ME/CFS project is developing a Clinical Decision Support System (CDSS) that integrates clinical expertise and diagnostic decision-making processes. It will utilize AI-based analyses of patient databases and a symptom-disease association model based on automated literature mining. The system is designed for multi-phase real-world evaluation and incorporates closed-loop learning mechanisms for continuous optimization.

Products by DETECT-ME/CFS project (ME/CFS Research Foundation)

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DETECT-ME/CFS project
DETECT-ME/CFS project (ME/CFS Research Foundation)
Clinical Decision Support & Reference
The DETECT-ME/CFS project is developing an AI-supported clinical decision support system to improve the rapid and reliable diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

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Last updated: 2026-09-19

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Press & Coverage

ME/CFS Research Foundation
ME/CFS Research Foundation invests u20ac2.4 million in new research projects
The ME/CFS Research Foundation has increased its funding volume to u20ac2.4 million to support seven new research projects across eight German institutions. These projects, selected from 30 submissions, will investigate new treatment approaches, disease mechanisms, and biomarkers for ME/CFS.
2026-07
mecfs-research.org
ME/CFS Research foundation announced funding for seven studies worth 2,4 million
Seven new research projects, totaling u20ac2.4 million in funding from the ME/CFS Research Foundation, are set to commence this summer. These projects, chosen from approximately 30 proposals, will focus on exploring novel treatment strategies, disease mechanisms, and biomarkers.
2026-07
ME/CFS Research Foundation
ME/CFS Research Foundation launches its 2026 research funding programme
The ME/CFS Research Foundation launched its 2026 research funding program in February 2026, making a total of u20ac2 million available for new research projects. The program aims to support biomedical research into unexplained disease mechanisms, biomarkers, and treatment options for ME/CFS.
2026-02
GOV.UK
Thousands of ME/CFS patients to benefit from genomics study - GOV.UK
The UK government is investing u00a34.75 million in the SequenceME program, the world's largest genomics study of ME/CFS, to sequence the genomes of up to 6,000 patients. This initiative aims to create a high-resolution genetic map of the illness, leading to better diagnostics and treatments.
2026-05
Duke University School of Medicine
The AI That's Finally Making Sense of Chronic Fatigue Syndrome
A new AI tool called BioMapAI, developed by scientists at the Jackson Laboratory and Duke University School of Medicine, can identify ME/CFS with 90% accuracy by analyzing routine lab tests. This tool maps the hidden biology of the condition and could lead to improved diagnosis and treatment.
2025-07
Cornell Center for Enervating NeuroImmune Disease
Blood Test for ME/CFS Shows Potential, But More Research Needed
A recent study in the Journal of Translational Medicine identified epigenetic changes in immune cells that could form the basis of a blood test for ME/CFS, achieving 96% accuracy in severe cases. While promising, researchers emphasize the need for further validation in larger cohorts.
2026-08
YouTube (Solve M.E.)
From Mystery to Measurable: The Science Behind the New ME/CFS Blood Test - YouTube
Scientists have developed a blood test that can identify ME/CFS with 96% accuracy by analyzing 3D genomic changes in DNA folding within blood cells. This breakthrough offers the potential for quicker, more confident diagnoses and insights into immune and inflammation pathways for targeted treatments.
2026-01
ME/CFS Research Foundation
International Declaration in Support of Research and Drug Development for ME/CFS and Long COVID
Over 60 leading international scientists and medical professionals signed a declaration calling for a globally coordinated approach to research and drug development for ME/CFS and Long COVID. The declaration highlights the urgent need for increased funding and collaborative efforts to address these interlinked public health crises.
2025-09
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