Duke Health

Durham, North Carolina, U.S. [13] All United States companies → — Founded 1998 [13]

AI Research Lab Clinical AI Platform Healthcare Conglomerate

Critical Care Emergency Medicine Infectious Disease

Clinical Decision Support & Reference Triage & ER/ICU AI

Unknown — Duke Health receives significant research funding, including over $1 billion in sponsored research expenditures annually for Duke University as a whole. [12, 21] The Duke University School of Medicine received over $514 million in sponsored research grants from the National Institutes of Health in 2025. [34] Duke University also received a $69 million grant from the NIH in 2025 to support the Duke Clinical and Translational Science Institute. [31] Additionally, Duke Health is part of a multi-institution research team that received a contract of up to $33 million in federal Advanced Research Projects Agency for Health (ARPA-H) funding for an osteoarthritis treatment. [21] In 2025, the Trump administration froze $108 million in federal funding for Duke Health amid a discrimination probe. [32, 37]

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Sepsis Watch

Duke Health

Clinical Decision Support & Reference

Sepsis Watch is a deep learning alert system developed by Duke Health to identify and manage sepsis in real-time within ED and ICU settings. It has been associated with a significant reduction in sepsis deaths and improved compliance with treatment protocols.

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About Duke Health

Duke Health is a world-class academic and healthcare system that integrates the Duke University Health System (hospitals and clinics), Duke University School of Medicine, Duke-NUS Medical School, Duke University School of Nursing, and the Duke Health Integrated Practice. [14, 15] It is committed to innovative scientific research, translating breakthrough discoveries to patient care, educating future clinical and scientific leaders, and improving community health while striving to eliminate health inequalities. [14, 15] Duke Health’s services encompass a full continuum of care, from primary care to medical and surgical specialties and subspecialties. [26]

Duke Health is actively involved in advancing healthcare through artificial intelligence (AI). [3, 5] Duke AI Health, a multidisciplinary initiative within the Duke University School of Medicine, focuses on research, training, and education in AI, machine learning, and data science applications for health and healthcare. [5, 9] They aim to leverage AI to address urgent challenges in medicine and population health, streamline administrative tasks, optimize resource allocation, and enhance clinical functions like patient scheduling and care coordination. [3, 6, 9] Duke Health also has an AI Evaluation & Governance Program dedicated to fostering continuous advancement in responsible health AI research and framework development, ensuring reliable selection, development, deployment, and utilization of AI technologies. [5, 6, 11]

In a strategic partnership with Trase Systems, Duke Health is developing advanced AI agents to reshape healthcare delivery. [3] This collaboration aims to build a comprehensive AI-powered ecosystem that integrates automation to bring data to action for clinical care, improve outcomes, and reduce costs. [3] Duke Heart staff are co-developing and testing these AI products to enhance clinician workflows, elevate the patient care experience, and improve health outcomes. [3] Researchers at Duke are also using AI to accelerate medical research, develop innovative AI technologies for patient care, and create governance frameworks for responsible AI integration in healthcare. [6] Examples include developing digital twins to simulate blood flow for personalized care and expanding an AI tool to predict early signs of mental illness in teenagers. [6]

Focus Areas

Healthcare delivery medical research medical education patient care AI in healthcare health equity digital health clinical transformation

Business Intelligence

Key Investors	Gothic HSP Corporation, The Duke Endowment, Jewish Communal Fund (as grantmakers)
Partnerships	Trase Systems, Microsoft, Novant Health, UNC Health, WakeMed, LifePoint Rehabilitation, Coalition for Health AI (CHAI), Vanderbilt University Medical Center (VUMC)
Acquisitions	Lake Norman Regional Medical Center (acquired April 2025, renamed Duke Health Lake Norman Hospital)
Technology	Duke Health Inference Platform (for augmented intelligence lifecycle), Microsoft Azure cloud environment, Azure OpenAI Service
FDA Clearances	unknown cleared products (estimated)

What Physicians Need to Know

Healthcare Delivery

Duke Health operates an extensive network of hospitals and over 400 medical clinics across North Carolina, providing primary care, specialty care, urgent care, and outpatient services. They are focused on expanding access to high-quality care, including through partnerships with local hospitals and a new partnership with Novant Health to build additional medical office campuses. They are also piloting care models that integrate bedside and virtual care to enhance safety, streamline workflows, and improve the patient experience.

Medical Research

Duke Health is a world-class academic and healthcare system committed to innovative basic and clinical research. The Duke University School of Medicine has over 2,500 basic and clinical researchers, and the Duke Clinical Research Institute (DCRI) is the world's largest academic clinical research organization. Their research has led to significant medical discoveries and treatments, including advancements in G-protein coupled receptors (underpinning 35% of medications), modern cochlear implants, the first effective treatment for Pompe disease, and insights into DNA repair for cancer treatment.

Medical Education

Duke Health provides a unique educational experience for future clinical and scientific leaders. The School of Medicine established the nation's first Physician Assistant Program in 1965, which is ranked #1 in the country. They offer international educational experiences through partnerships with Duke-NUS Medical School in Singapore and Duke Kunshan University. Their new Patient FIRST curriculum focuses on developing inquiry and lifelong learning, integrating biomedical sciences with clinical reasoning and the social context of medicine.

Patient Care

Duke Health is committed to delivering high-quality, patient-centered care, striving to establish new standards for outcomes and safety. They emphasize fostering long-term doctor-patient relationships and actively seek patient feedback to improve experiences. The My Duke Health App provides a tailored experience for online health care interactions, allowing patients to manage appointments, access virtual urgent care, and find educational resources.

AI in Healthcare

Duke Health is leveraging AI to accelerate medical research, improve patient care, and develop governance frameworks for responsible AI integration. The Duke Health AI & Governance program streamlines health AI evaluation and governance to ensure solutions are safe, effective, and reduce disparities. Initiatives include AI-powered diabetic retinopathy screening, an AI tool to predict teen mental illness, and the development of digital twins for simulating blood flow and optimizing healthcare operations.

Health Equity

Duke Health is committed to delivering equitable healthcare and eliminating health disparities. They address socioeconomic determinants of health like food insecurity and housing concerns through community partnerships. The Collaborative to Advance Clinical Health Equity (CACHE) uses data science to identify and address disparities in clinical outcomes. They also have programs like the Mobile Prevention and Care Team Clinic to increase healthcare access in rural and underserved urban populations.

Digital Health

Duke Health is forging its digital future by expanding telehealth options and developing cutting-edge digital health services that are customized, convenient, high quality, and accessible. Their Virtual Care Center (VCC) centralizes telehealth, improving patient and physician experiences and reducing operating costs. They are also exploring the use of wearables, connected devices, and text messaging for population health and to reduce health disparities.

Clinical Transformation

Duke Health is undergoing a complex transformation to unify its health system and physician practice, aiming for strategic and operational alignment, increased efficiency, and diversified growth. They are implementing new models of care, including integrating new technologies into 'Innovation Units' within the hospital to support patients and staff. The Duke-Margolis health care transformation portfolio identifies care delivery and payment transformation strategies with real-world impact.

Physician Tip

Duke Health offers physicians a unique environment for professional growth and impact. They are a top-ranked medical center with world-renowned training and patient care, providing exposure to a wide range of complex procedures and cutting-edge research opportunities. The institution actively invests in the development and long-term success of its workforce, including tuition assistance and structured residency programs. Physicians benefit from a unified electronic health record system (Epic EHR) designed for resilience and continuous access to patient data, reducing cognitive burden and improving patient safety. Duke Health also emphasizes a culture of respect and belonging, with initiatives to support team members and address physician burnout. Furthermore, opportunities exist to engage in groundbreaking research, lead health care transformation efforts through data science and AI, and contribute to health equity initiatives.

Duke Health leverages a robust technology stack to support its mission. Their Electronic Health Record (EHR) system is Epic, with disaster recovery on Microsoft Azure to ensure continuous operation and data resilience. For AI and data initiatives, they utilize the Duke Health Inference Platform for data curation, model development, deployment, and monitoring. The Duke Health Data Pipeline, powered by DIHI, integrates and standardizes EHR, clinical outcomes, claims, and other data sources, leveraging technologies and best practices from major tech companies like Google, Uber, and Airbnb. They have formalized a strategic analytics and AI collaboration with SAS, gaining access to the SAS Viya data and AI platform and health applications. Other technologies mentioned include React, Grouper, Shibboleth, Google Analytics, Mapbox, Ruby on Rails, and Swagger for their SDOH Research Platform. They also integrate digital care tools with patients through the EHR system, including educational videos and mobile apps, with an analytics dashboard providing insights into patient usage.

At a glance

Founded 1998 [13]

HQ Durham, North Carolina, U.S. [13] · United States

Team size Approximately 26,278 full-time employees (Duke University Health System) [12, 13]

CEO David Zaas, M.D., MBA [1, 2, 8]

Funding Unknown — Duke Health receives significant research funding, including over $1 billion in sponsored research expenditures annually for Duke University as a whole. [12, 21] The Duke University School of Medicine received over $514 million in sponsored research grants from the National Institutes of Health in 2025. [34] Duke University also received a $69 million grant from the NIH in 2025 to support the Duke Clinical and Translational Science Institute. [31] Additionally, Duke Health is part of a multi-institution research team that received a contract of up to $33 million in federal Advanced Research Projects Agency for Health (ARPA-H) funding for an osteoarthritis treatment. [21] In 2025, the Trump administration froze $108 million in federal funding for Duke Health amid a discrimination probe. [32, 37]

FDA clearances unknown (estimated)

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Products by Duke Health

1 product in the directory

Sepsis Watch

Duke Health

Clinical Decision Support & Reference

What the Web Says

Duke Health is generally well-regarded as a healthcare provider, known for its high-quality medical care, research, and academic excellence. As an employer, it receives mixed reviews, with some praising its benefits and opportunities for growth, while others point to issues with work-life balance and management.

Overall: Mixed

Strengths

High-quality medical care and advanced treatments
Strong reputation for research and academic excellence
Comprehensive benefits package for employees
Opportunities for professional growth and development
Cutting-edge technology and facilities
Commitment to patient care and outcomes

Limitations

Challenges with work-life balance for some employees
Bureaucratic environment due to large size
Management inconsistencies reported in some departments
High cost of services for patients without good insurance
Parking issues on campus for both patients and staff
High patient volume can lead to long wait times

Based on reviews from: Glassdoor, Reddit, U.S. News & World Report (general healthcare reviews), Indeed (employer reviews)

Last updated: 2026-10-02

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Press & Coverage

Duke Health

Mary Klotman, Duke's Chief Academic Health Leader, will Complete Service in 2027

Mary Klotman, MD, will complete her service as Executive Vice President for Health Affairs at Duke University, Dean of the School of Medicine, and Chief Academic Officer for Duke Health in 2027.

2026-09

Duke Health

First Remote-Controlled Device for Male Incontinence in U.S. Implanted at Duke

Duke Health has implanted the first remote-controlled device in the U.S. for male incontinence, marking a significant advancement in clinical care and urology.

2026-08

Duke Health

Real-World Study Provides New Insights into Safety of New Alzheimer's Drug

A real-world study conducted by Duke Health offers new insights into the safety profile of a new Alzheimer's drug.

2026-08

Duke Health

Duke Health to Continue Caring for State Health Plan Members Under New Access Provider Network

Duke Health will continue to provide care for State Health Plan members through a new access provider network.

2026-07

Duke Health

Duke & UNC Researchers to co-lead $12.9M Study to Improve Care for Autistic Children

Researchers from Duke and UNC will co-lead a $12.9 million study aimed at improving care for autistic children.

2026-04

This Week Health

Duke Health, Lenovo Teaming Up to Design Hospital Using Assistive Intelligence

Duke Health and Lenovo are collaborating to design a future hospital model that integrates advanced technologies, including 'assistive intelligence,' to enhance patient care and operations.

2026-02

MedCity News

Inside Duke's Approach to Building and Buying AI Tools

Duke University Health System is strategically deploying both internally developed and acquired AI tools to reduce administrative burdens for clinicians and enhance patient care.

2025-09

Fierce Healthcare

Microsoft, Duke Health launch 5-year partnership to explore healthcare AI, deploy cloud tech

Duke University Health System and Microsoft have initiated a five-year partnership to explore generative AI and cloud technologies, aiming to modernize IT operations and develop new AI-based clinical tools.

2023-08

Frequently Asked Questions

How does Duke Health integrate AI into its clinical workflows and what are the tangible benefits observed in patient care and operational efficiency?

Duke Health leverages AI for various applications, including predictive analytics for patient outcomes, personalized treatment plans, and optimizing operational efficiencies in areas like scheduling and resource allocation. These integrations aim to enhance diagnostic accuracy, streamline administrative tasks, and ultimately improve the quality and accessibility of patient care.

What initiatives is Duke Health undertaking to address health equity and reduce disparities in healthcare access and outcomes within its service areas?

Duke Health is committed to health equity through community outreach programs, targeted interventions for underserved populations, and research focused on identifying and mitigating healthcare disparities. Efforts include expanding access to care in rural areas, culturally sensitive patient education, and partnerships with local organizations to address social determinants of health.

Can you elaborate on Duke Health's approach to digital health, including its platforms for telemedicine, remote monitoring, and patient engagement, and how these contribute to clinical transformation?

Duke Health's digital health strategy encompasses robust telemedicine services, remote patient monitoring programs for chronic disease management, and a comprehensive patient portal for engagement. These platforms are central to enhancing patient access, promoting self-management, and enabling continuous care, thereby driving clinical transformation towards more patient-centered and efficient models.

What are Duke Health's key priorities and recent achievements in medical research, particularly in areas that are poised to impact future healthcare delivery?

Duke Health is a leader in medical research, with significant advancements in areas such as cancer immunotherapy, cardiovascular disease, neuroscience, and genomics. Recent achievements include breakthroughs in novel drug therapies, innovative surgical techniques, and a strong focus on translational research that directly impacts clinical practice and future healthcare delivery.

How does Duke Health foster medical education and professional development for its physicians and healthcare administrators, ensuring they remain at the forefront of evolving medical practices and leadership skills?

Duke Health provides extensive opportunities for medical education and professional development, including residency and fellowship programs, continuing medical education (CME) courses, and leadership training for administrators. These initiatives ensure that staff are equipped with the latest medical knowledge, clinical skills, and leadership competencies to navigate the evolving healthcare landscape.

What is Duke Health's strategy for partnerships with external organizations, including technology companies, startups, or other healthcare systems, to drive innovation and expand its reach?

Duke Health actively seeks strategic partnerships with technology companies, startups, and other healthcare systems to foster innovation and extend its impact. These collaborations focus on developing new digital health solutions, advancing medical research, and expanding access to specialized care, ultimately enhancing the value and reach of Duke Health's services.