Oxford Brain Diagnostics
About Oxford Brain Diagnostics
Oxford Brain Diagnostics is a healthcare AI company specializing in the early and differential diagnosis, progression tracking, and prognosis of neurodegenerative diseases. Their core technology, Cortical Disarray Measurement (CDM®), is a patented software-based analysis that utilizes standard magnetic resonance imaging (MRI) scans to detect microscopic alterations within the brain’s gray matter. This innovative approach provides an objective, quantifiable measure of neurodegeneration by analyzing the diffusion properties of water in the brain’s cortical minicolumns, which are known to be altered in conditions such as Alzheimer’s disease and Parkinson’s disease.
The CDM® technology offers insights into brain health at a cellular level, previously only accessible through post-mortem examination, enabling clinicians to identify neurodegenerative changes years before traditional symptoms manifest or standard MRI scans show macroscopic changes. Oxford Brain Diagnostics’ platform has received FDA Breakthrough Device Designation for evaluating adults at risk of Alzheimer’s Disease, and has secured FDA 510(k) clearance and UKCA self-certification, facilitating its commercial rollout in the US and UK healthcare sectors. Beyond clinical diagnosis, the technology also supports pharmaceutical and biotechnology companies in more targeted and efficient drug development and clinical trials for various neurodegenerative conditions.
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| Key Investors | BGF, Oxford Technology & Innovations Fund (OTIF), University of Oxford Innovation Fund (UOIF) IV, Parkwalk Advisors, RT Capital, University of Oxford, Grow London, Barossa, Fushia Investments, iHealthexpress |
| Partnerships | Caladrix (Phase 1b Trial of C-001 in Alzheimer's Disease), AbbVie (Parkinson's Disease research), INmune Bio (XPro1595 in Alzheimer's Patients), The Michael J. Fox Foundation (Parkinson's research), NeuroTherapia (Alzheimer's Phase 2 Clinical Trial), Florida Memory Treatment Centers |
| Technology | Cortical Disarray Measurement (CDM®) technology, CDM Insights software, cloud-native, AI algorithms, diffusion MRI analysis, processes standard MRI scans (1.5T and 3T), multi-cloud approach (OVHcloud and hyperscale cloud providers) |
| FDA Clearances | 1 cleared products (estimated) |
What Physicians Need to Know
For physicians, Oxford Brain Diagnostics' CDM Insights offers a revolutionary tool for early and precise assessment of brain health. It provides objective, quantifiable insights into cellular-level neurodegeneration from standard MRI scans, enabling earlier diagnosis, more informed treatment decisions, and proactive patient management. The ability to detect microstructural changes years before symptoms appear can significantly impact patient pathways, allowing for earlier intervention and personalized care, especially with the advent of new anti-amyloid Alzheimer's drugs. The comprehensive reports, including normative comparisons and longitudinal tracking, offer a deeper understanding of disease progression and response to treatment. The non-invasive, FDA-cleared, and HIPAA-compliant nature of the software, coupled with quick report turnaround times (within 12 hours), makes it a practical and valuable addition to neurological diagnostics.
CDM Insights is designed to integrate seamlessly with existing PACS systems, processing standard anatomical and diffusion MRI data in a secure cloud environment. This allows for efficient workflow and timely access to advanced diagnostic reports for clinicians. The platform is built on a multi-cloud approach, utilizing hyperscale cloud providers and OVHcloud for robust data storage and compute capabilities.
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