SamaCare

San Francisco, California, US All United States companies → — Founded 2018

Prior Authorization Automation Revenue Cycle / Billing

Family Medicine Internal Medicine Oncology

Practice Management & Scheduling Prior Authorization

Series B — $34.8M

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SamaCare

Practice Management & Scheduling

SamaCare is an AI-native platform that streamlines medical benefit prior authorization for specialty practices, improving approval rates and reducing time to resolution.

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About SamaCare

SamaCare is a healthcare AI company that provides a cloud-based workflow intelligence platform designed to streamline the prior authorization process for specialty medications. The company’s platform aims to reduce the administrative burden on medical practices, improve approval rates, and add predictability to patient care. By digitizing the often manual and paper-heavy prior authorization process, SamaCare helps to prevent treatment delays and ensures patients receive necessary life-changing therapies sooner.

For physicians, SamaCare’s platform offers a unified portal experience for prior authorization, enrollment, and benefits verification across various payers and specialty drugs. This includes practices in specialties such as retina, oncology, neurology, and rheumatology. The company leverages a combination of AI technology and human expertise to automate workflows, reduce avoidable errors, and provide faster and more accurate results. SamaCare also works with pharmaceutical manufacturers to provide insights into access barriers and support patient services teams, ultimately aiming to improve patient access to therapeutics.

Focus Areas

prior authorization specialty medications patient access workflow automation AI in healthcare benefits verification market access for pharmaceuticals

Business Intelligence

Key Investors	Questa Capital, Vive Collective, South Park Commons, NextView Ventures, Susa Capital
Partnerships	McKesson, Cencora, WeInfuse, specialty networks, ARN, Neuronet GPO, NICA
Acquisitions	none
Technology	cloud-based workflow automation platform, AI-native intelligence, human-in-the-loop AI processes, real-time dataset of medical benefit prior authorizations

What Physicians Need to Know

Prior Authorization & Specialty Medications

SamaCare is a leading platform for medical benefit prior authorizations, especially for specialty drugs. They processed over $6.2 billion in specialty medication prior authorizations in 2025. Their platform combines AI and human oversight to accelerate approvals, reduce preventable denials, and improve patient access by 40-90%. They offer a unified prior authorization, enrollment, and benefits verification portal experience for specialty medications across various payers.

Workflow Automation

SamaCare provides a cloud-based workflow automation platform that streamlines prior authorization, enrollment, and benefit verification for medical practices. Their AI-driven system automates manual tasks, such as form selection, clinical document preparation, payer submission, and status verification. This automation includes built-in checkpoints requiring human approval and automated navigation of payer rules to prevent common denial triggers.

AI in Healthcare

SamaCare leverages AI trained on millions of prior authorizations (over 2 million as of early 2026) to automate and intelligently guide the prior authorization process. Their AI-native intelligence is embedded directly into specialty practice workflows, offering transparent, interactive guidance on recommended forms, documentation, and submission pathways. This AI constantly learns from frontline prior authorization specialists.

Medical Benefit Management & Revenue Cycle Management

SamaCare's platform simplifies prior authorizations for buy-and-bill drugs, imaging, and select procedures, reducing administrative burdens and improving approval timelines. They provide real-time insights into payer behavior, policy friction, and approval patterns, which can help practices optimize operations and engage with payers more effectively. Their system aims to enhance patient access and streamline provider operations, contributing to revenue cycle efficiency by preventing unnecessary delays to care.

Patient Access

SamaCare is dedicated to improving patient access to specialty therapies by transforming the prior authorization process. Their platform has been shown to improve patient access by 40-90% and reduce therapy abandonment by 24%. They provide in-workflow education and support to healthcare providers, with a measurable impact on approval rates and time to therapy.

Physician Tip

SamaCare offers a unified and automated platform for prior authorizations, reducing administrative burden and saving time. The platform provides transparent, AI-driven guidance to help avoid common mistakes, reduce delays, and understand authorization processes in real-time. It's free for medical practices to use, and offers insights into payer behavior and benchmarks to compare your practice's performance. This allows physicians and their staff to focus more on patient care and less on paperwork.

SamaCare is built to integrate with existing healthcare technology ecosystems, including Electronic Medical Records (EMRs) and Revenue Cycle Management (RCM) platforms. They also participate in industry initiatives to advance interoperability and prior authorization standards. An example integration includes seamless data transfer with NextGenu00ae EHR.

At a glance

Founded 2018

HQ San Francisco, California, US · United States

Team size 51-200

CEO Syam Palakurthy

Funding Series B — $34.8M

Products 1

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Products by SamaCare

1 product in the directory

SamaCare

Practice Management & Scheduling

SamaCare is an AI-native platform that streamlines medical benefit prior authorization for specialty practices, improving approval rates and reducing time to resolution.

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Press & Coverage

PR Newswire

SamaCare Secures $17M Series B Investment to Scale Specialty Drug Prior Authorization Platform

SamaCare closed an oversubscribed $17 million Series B funding round led by Questa Capital, with participation from existing investors Vive Collective and South Park Commons, to accelerate product development and expand its patient access platform.

2024-05

Pharmaceutical Executive

SamaCare Announces 1 Million Prior-Authorizations Completed Using AI Platform

SamaCare announced reaching one million prior authorizations completed using its AI-powered platform, highlighting the combination of AI technology and human expertise for faster and more accurate results in streamlining the script-to-therapy process.

2025-06

PR Newswire

SamaCare Launches SamaCare Plus: AI-Driven Touchless Prior Authorizations Built for Provider Control

SamaCare launched SamaCare Plus, a new AI offering that automates and intelligently guides the prior authorization process while maintaining provider control, built on insights from nearly 2 million prior authorizations.

2025-11

Clearlake Capital Group

SamaCare, a Cloud-Based Prior Authorization Platform for Specialty Medications, Closes $12M Series A to Expand Company's Reach

SamaCare closed a $12 million Series A funding round led by Clearlake Capital-backed Vive Collective, with participation from NextView Ventures, South Park Commons, and Susa Capital, to expand its presence in existing and new specialties.

2022-06

Osmosis

Making Prior Authorization as Easy as a Credit Card Swipe - Syam Palakurthy, Co-Founder and CEO at SamaCare

An interview with CEO Syam Palakurthy discusses how SamaCare's software aims to simplify the burdensome prior authorization process, comparing it to a credit card swipe to improve patient outcomes and reduce administrative load for providers.

2022-04

Inc. Magazine

SamaCare is a 2026 Inc. 5000 honoree

SamaCare was recognized as an Inc. 5000 honoree in 2026, highlighting its growth and position as a cloud-based workflow intelligence platform for streamlining specialty drug prior authorization processes.

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Frequently Asked Questions

How does SamaCare specifically address the challenges of prior authorization for specialty medications?

SamaCare streamlines the prior authorization process by automating the collection of necessary documentation and submission to payers, significantly reducing administrative burden and accelerating time to therapy for specialty medications. This helps physicians and healthcare administrators overcome common hurdles like complex forms and frequent denials, improving patient access to critical treatments.

What role does AI play in SamaCare's platform, particularly in enhancing workflow automation and patient access?

SamaCare leverages AI to automate repetitive tasks within the prior authorization and benefits verification workflows, such as data extraction and form population. This not only increases efficiency for healthcare providers but also helps identify potential access barriers earlier, ensuring a smoother and faster path for patients to receive their specialty medications.

How does SamaCare ensure compliance with healthcare regulations and data security standards when handling sensitive patient information?

SamaCare is committed to maintaining the highest standards of compliance and data security, adhering to regulations like HIPAA. The platform incorporates robust security measures, including encryption and access controls, to protect sensitive patient information throughout the prior authorization and patient support processes.

Can SamaCare integrate with our existing electronic health record (EHR) system to further optimize our workflow?

SamaCare is designed to integrate with various EHR systems, allowing for seamless data exchange and further automation of the prior authorization and patient access workflows. This integration minimizes manual data entry, reduces errors, and provides a more unified and efficient experience for healthcare providers.

What kind of support and training does SamaCare offer to ensure our team can effectively utilize the platform?

SamaCare provides comprehensive support and training programs to ensure healthcare teams can effectively implement and utilize the platform. This includes onboarding assistance, ongoing technical support, and resources to help users maximize the benefits of SamaCare's solutions for prior authorization and patient access.

How does SamaCare's solution impact the financial aspects of specialty medication management, including benefits verification and potential cost savings?

SamaCare significantly improves benefits verification by automating the process and providing real-time insights into patient coverage for specialty medications. This reduces claim denials, minimizes administrative costs associated with manual verification, and helps identify financial assistance options for patients, ultimately leading to potential cost savings for both patients and healthcare providers.

What is SamaCare's approach to market access for pharmaceutical products, and how does it benefit prescribers and patients?

SamaCare's platform helps improve market access for pharmaceutical products by streamlining the complex prior authorization and patient support processes. By reducing administrative hurdles and accelerating access to specialty medications, SamaCare benefits prescribers by simplifying their workflow and patients by ensuring timely access to necessary treatments.

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