Products

EndoNaut
Therenva SAS
Radiology & Imaging AI
EndoNaut by Therenva SAS is an AI-powered image fusion device for intraoperative 3D navigation in endovascular procedures, designed to enhance precision and reduce radiation exposure and contrast media.

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About Therenva SAS

Therenva SAS is a healthcare AI company specializing in advanced imaging software solutions for cardiovascular procedures. Their core offerings, EndoSize and EndoNaut, are designed to assist physicians and healthcare professionals throughout the planning and execution of minimally invasive endovascular interventions. EndoSize provides AI-based image processing for accurate and efficient segmentation and detection of anatomical structures, facilitating precise measurements and comprehensive case planning for various cardiovascular pathologies, including aortic aneurysm repair, aortic dissections, carotid artery disease, peripheral artery disease, and structural heart interventions like TAVI/TAVR and TMVR.

EndoNaut, a patented solution, offers intra-operative 3D navigation and localization of devices. It aligns pre-operative 3D data from EndoSize with 2D fluoroscopic images, providing real-time guidance, enhanced accuracy, and visual comfort during catheterization procedures. This integration of AI, deep learning, and biomechanical simulation in their software toolset aims to standardize and streamline workflows, ultimately improving patient care by enabling more efficient and safer endovascular interventions.

Since its acquisition by Ziehm Imaging in 2020, Therenva’s portfolio is being leveraged globally through Ziehm’s distribution network, with a focus on co-developing new solutions for enhanced pre- and intra-operative image-based decision support systems in cardiovascular and potentially other clinical areas.

Focus Areas

Medical imaging software cardiovascular procedures endovascular interventions AI deep learning biomechanical simulation endovascular case planning intraoperative navigation TAVI TMVR aneurysm repair artery/vein embolization peripheral artery disease treatment image fusion

Business Intelligence

Key InvestorsEuropa (prior to acquisition), Ziehm Imaging (acquirer)
PartnershipsZiehm Imaging (parent company and technology partner), Bucharest Sanador Clinic, CHUV Lausanne
AcquisitionsAcquired by Ziehm Imaging on July 27, 2020
TechnologyAI-based image processing, deep learning, biomechanical simulation, image fusion technology, compatible with mobile and fixed C-arms, DICOM integration
FDA Clearances2 cleared products (estimated)

What Physicians Need to Know

Medical Imaging Software
Therenva specializes in developing advanced and user-friendly imaging software toolsets specifically designed for cardiovascular procedures.
Cardiovascular Procedures & Endovascular Interventions
Their software solutions, EndoSize and EndoNaut, enable physicians to efficiently plan and safely execute a wide range of minimally invasive endovascular interventions.
AI & Deep Learning
Both EndoSize and EndoNaut leverage cutting-edge data processing algorithms, including AI and deep learning, for automated segmentation, detection of anatomical structures, and precise image registration.
Biomechanical Simulation
The software incorporates biomechanical simulation, particularly for predicting vascular deformation, which is crucial for accurate intraoperative navigation.
Endovascular Case Planning
EndoSize is a dedicated 3D case planning software that allows surgeons to fully plan treatment strategies, accurately measure anatomy from CT images, suggest appropriate device designs, and define relevant parameters in minutes.
Intraoperative Navigation
EndoNaut is an intraoperative navigation system that utilizes AI-based image fusion technology to provide precise visualization and guidance to surgeons during endovascular procedures.
TAVI & TMVR Planning
EndoSize includes specialized AI-based modules for planning Transcatheter Aortic Valve Implantation (TAVI/TAVR) and Transcatheter Mitral Valve Replacement (TMVR) treatments, featuring automatic valve segmentation and measurements.
Aneurysm Repair
Their solutions support the planning and navigation of various aneurysm repairs, including aorto-iliac, thoracic, and thoraco-abdominal aneurysms.
Artery/Vein Embolization
EndoNaut is indicated for assisting in procedures such as artery/vein embolization.
Peripheral Artery Disease (PAD) Treatment
Both EndoSize and EndoNaut offer modules dedicated to peripheral artery disease treatment, including 2D panorama navigation and image fusion for PAD procedures.
Image Fusion
EndoNaut employs AI-based patented image registration algorithms to automatically merge fluoroscopy and CT images, delivering high-quality 3D image fusion for enhanced intraoperative visualization.
Physician Tip

Therenva's solutions, EndoSize and EndoNaut, are designed to significantly enhance precision and safety in endovascular interventions through AI-powered planning and navigation. Physicians can expect streamlined preoperative workflows with automated measurements and rapid case planning, saving valuable time. The image fusion technology in EndoNaut helps to substantially reduce patient and staff exposure to X-ray radiation and contrast media. Detailed 3D anatomical models, predictive simulations of vascular deformation, and comprehensive planning reports empower physicians with better decision-making capabilities for optimal treatment strategies and device selection. The versatility of their applications covers a broad spectrum of cardiovascular procedures, from complex aneurysm repair and TAVI/TMVR to peripheral artery disease treatments. Furthermore, EndoNaut's compatibility with existing C-arm systems and intuitive control directly from the interventional table ensures seamless integration into any operating room environment.

Therenva's EndoNaut system is engineered for broad compatibility, integrating seamlessly with most existing mobile and fixed C-arm systems from various manufacturers. The software facilitates efficient data flow by supporting direct DICOM image import from PACS, medical cloud systems, hard disks, and CD-ROMs for both preoperative planning and intraoperative navigation. Therenva has a notable strategic partnership with Ziehm Imaging, which enables deeper software and hardware integration, leading to enhanced and more seamless workflows for clinicians.

Products by Therenva SAS

1 product in the directory

EndoNaut
Therenva SAS
Radiology & Imaging AI
EndoNaut by Therenva SAS is an AI-powered image fusion device for intraoperative 3D navigation in endovascular procedures, designed to enhance precision and reduce radiation exposure and contrast media.

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Press & Coverage

Therenva
ENDONAUT CLINICAL DATA PUBLISHED IN JVS
A clinical study published in the Journal of Vascular Surgery showed that Therenva's EndoNaut system significantly reduced radiation dose and contrast agent volume by over 30% in EVAR procedures. This study was conducted by Bordeaux University Hospital and Libourne Hospital on over 250 patients.
2026-07
Therenva
AI-POWERED ENDOSIZE CARDIO FOR TAVI AND TMVR CASE PLANNING
Therenva has released new TAVI and TMVR case planning modules for its EndoSize Cardio software, which feature automatic AI-based valve segmentation. This advancement aims to empower physicians with user-friendly solutions for structural heart treatments.
2026-07
Therenva
ENDONAUT NOW IN ROMANIA'S FIRST MOBILE HYBRID SUITE!
Therenva's EndoNaut system is now being utilized in Romania's first mobile hybrid suite at Bucharest Sanador Clinic, marking a pioneering advancement in endovascular surgery. This expansion is part of Therenva's efforts to support physicians in more countries through the Ziehm partner network.
2026-07
Therenva
ENDOVASCULAR NAVIGATION INTEGRATED INTO A MOBILE C-ARM, NOW AVAILABLE
Therenva announced the availability of the first-ever image fusion technology natively integrated into a single Ziehm C-Arm interface, providing an easy, fast, and seamless workflow for physicians. This integration aims to achieve higher accuracy and greater confidence during demanding hybrid procedures.
2026-07
DAIC
Ziehm Imaging Acquires French Imaging Software Developer Therenva
Ziehm Imaging acquired Therenva in August 2020, building on a two-year market cooperation. This acquisition allows Ziehm to globally market Therenva's EndoSize and EndoNaut solutions and focuses on co-developing new image-based decision support systems.
2020-08
FDA
510(k) Premarket Notification for EndoNaut
The FDA issued a 510(k) clearance for Therenva SAS's EndoNaut, an image fusion software solution and computerized navigational system, on October 25, 2022. It is intended to assist X-ray fluoroscopy-guided procedures in positioning surgical instruments and endovascular devices.
2022-10
PubMed (Journal of Vascular Surgery)
EndoNaut two-dimensional fusion imaging with a mobile C-arm for endovascular treatment of occlusive peripheral arterial disease
A clinical study published in the Journal of Vascular Surgery in September 2021 demonstrated that Therenva's EndoNaut 2D fusion imaging system significantly reduced contrast medium volume and dose-area product in endovascular treatment of peripheral arterial disease. The study observed a reduction of over 30% for both operative parameters.
2021-09
PubMed (Journal of Vascular Surgery)
Sizing for endovascular aneurysm repair: clinical evaluation of a new automated three-dimensional software
This peer-reviewed article from October 2010 evaluates Therenva's EndoSize software for automated 3D sizing in endovascular aneurysm repair, concluding that it is as reliable as conventional radiological procedures and offers reproducible results for surgeons.
2010-10

Frequently Asked Questions

Therenva's software, including EndoSize for planning and EndoNaut for navigation, leverages AI, deep learning, and biomechanical simulation to optimize endovascular procedures. EndoSize uses AI for automated segmentation and precise measurements in preoperative planning, while EndoNaut employs AI-based image fusion for accurate intraoperative guidance, merging fluoroscopy and CT images to enhance precision and safety.
Therenva's EndoSize software offers dedicated workflows for structural heart interventions like TAVI/TAVR and TMVR, as well as vascular procedures including aorta aneurysm repair, aorta dissections, carotid artery disease, and peripheral artery disease. EndoNaut further assists in fluoroscopy-guided procedures across the chest, abdomen, pelvis, neck, and lower limbs for interventions such as aneurysm repair, artery/vein embolization, and peripheral artery disease treatment.
Therenva's EndoNaut provides high-quality, AI-based image fusion by merging preoperative CT images with live fluoroscopy, offering enhanced confidence, accuracy, and visual comfort during procedures. This technology helps reduce the need for contrast media and X-ray dose, while providing precise intraoperative navigation and predictive simulation of vascular deformation.
Both Therenva's EndoSize and EndoNaut software have received FDA 510(k) clearance in the USA, demonstrating substantial equivalence for their intended uses. In Europe, EndoSize is CE marked as a Class IIa medical device, and EndoNaut as a Class IIb device, ensuring compliance with European regulatory standards.
Therenva's EndoNaut is designed for seamless integration, compatible with any mobile or fixed C-arm system, and can connect to PACS or NAS servers for data import. EndoSize supports DICOM image import from various sources, and the company provides integration manuals and developer documentation for its server versions. Therenva also offers customized modules and boasts high customer and service satisfaction.
While specific pricing models are not publicly detailed, Therenva's website indicates separate pricing for its EndoSize and EndoNaut solutions, suggesting a modular or per-product licensing approach. Healthcare providers interested in their solutions are encouraged to contact Therenva directly for detailed pricing information and customized offers.
Therenva SAS was acquired by Ziehm Imaging in 2020, which significantly enhances its company stability and strategic reach. This partnership focuses on co-developing integrated solutions for advanced image-based decision support in cardiovascular and other clinical areas, driving deeper software and hardware integration.

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