HeartFlow Analysis vs ZEUS System

Similar category, different focus. These tools serve overlapping but distinct needs. Comparability 65/100 Comparability is an AI-graded 0–100 score of how directly these two tools compete — higher means a more apples-to-apples comparison.
by Heartflow
VS
by iRhythm Technologies, Inc.

AI Verdict

HeartFlow Analysis provides AI-powered diagnostics for coronary artery disease using CT scans, focusing on structural issues and blood flow. The ZEUS System, conversely, utilizes AI to analyze ECG data from wearable sensors for the detection and characterization of cardiac arrhythmias. While both are cardiology AI tools, they address different cardiac conditions and employ distinct data sources and methodologies.

Choose HeartFlow Analysis if…

Choose HeartFlow Analysis if you need a non-invasive, highly accurate assessment of coronary artery disease (CAD) severity and its functional impact. This tool is ideal for patients with suspected CAD who have undergone a CT scan, providing detailed 3D models and FFRct analysis to guide decisions on further invasive procedures or treatment plans.

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Choose ZEUS System if…

Choose the ZEUS System if you require long-term, continuous cardiac monitoring to detect and characterize intermittent or asymptomatic arrhythmias. This AI-powered wearable solution is best suited for patients experiencing infrequent symptoms like palpitations or those at risk for conditions such as Atrial Fibrillation, where extended ECG data analysis is crucial for diagnosis and management.

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Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Quick Comparison

Feature HeartFlow Analysis ZEUS System
Pricing Contact vendor for pricing Not disclosed
Deployment Cloud-based (AWS) Cloud-based (AWS EC2 platform), no on-premise hardware.
BAA Available Yes AI-estimated Yes AI-estimated
FDA Status Cleared AI-estimated Cleared AI-estimated
HIPAA Unknown Yes AI-estimated

Feature-by-Feature

Detail beyond the Quick Comparison summary. For pricing, deployment, BAA, FDA, and HIPAA see the Overview tab.

Feature HeartFlow Analysis ZEUS System
Name HeartFlow Analysis ZEUS System
Company HeartFlow iRhythm Technologies
Description Commercial-stage medical technology company providing software and artificial intelligence (AI) designed to deliver a non-invasive solution for diagnosing and managing coronary artery disease (CAD) by creating personalized 3D models of patients' coronary arteries from standard CT scans. AI-powered software that analyzes ECG data from wearable biosensors for long-term continuous cardiac monitoring, aiding in the detection and characterization of arrhythmias like Atrial Fibrillation.
Primary Focus Diagnosing and managing coronary artery disease (CAD) Detection and characterization of arrhythmias like Atrial Fibrillation
Key Features AI-powered 3D modeling of coronary arteries, Fractional Flow Reserve derived from CT (FFRct) analysis, Plaque Analysis (quantification and characterization), Roadmapu2122 Analysis for CCTA reading, Non-invasive diagnostic assessment, Personalized patient insights, Computational Fluid Dynamics (CFD) for blood flow simulation, High diagnostic accuracy AI-powered arrhythmia detection, Continuous ECG monitoring (up to 14 days), Cloud-based data analytics, Detection and characterization of Atrial Fibrillation (AFib), Preliminary report generation for physicians, Integration with Zio Watch and Zio monitors, Support for symptomatic and asymptomatic cardiac events, HL7-based EHR integration

Videos

Demos, reviews, and walkthroughs featuring HeartFlow Analysis and ZEUS System.

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Frequently Asked Questions

HeartFlow Analysis is designed for the non-invasive diagnosis and management of coronary artery disease (CAD) by creating personalized 3D models of patients' coronary arteries from standard CT scans. The ZEUS System, by iRhythm Technologies, focuses on long-term continuous cardiac monitoring to detect and characterize arrhythmias like Atrial Fibrillation using data from wearable biosensors.
HeartFlow Analysis processes data from standard CT scans to generate its insights, including AI-powered 3D modeling, FFRct analysis, and plaque analysis. The ZEUS System analyzes continuous ECG data collected from wearable biosensors, such as Zio Watch and Zio monitors.
HeartFlow Analysis operates on a fee-for-service model and is covered by Medicare and most U.S. commercial payers, with established Category I CPT codes for FFRct Analysis (75580) and AI-Enabled Quantitative Plaque Analysis (75577 for 2026). Pricing details for the ZEUS System are not disclosed.
HeartFlow Analysis provides AI-powered 3D modeling of coronary arteries, Fractional Flow Reserve derived from CT (FFRct) analysis, and plaque quantification and characterization. The ZEUS System offers AI-powered arrhythmia detection, characterization of conditions like Atrial Fibrillation, and preliminary report generation from continuous ECG monitoring.

Backers

Who funded each tool's parent company.

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