Big Bets

VC AI focus Sao Paulo, Brazil · Founded 2018

Focuses on very early-stage "bets" on high-potential technical teams in Brazil.

About Big Bets

Big Bets is a Sao Paulo Pre-Seed and Seed fund that backs very early-stage Brazilian technical teams, writing checks under $250k. The name signals the underwriting style: small concentrated tickets into founders the fund believes can build category-defining companies from a clean sheet of paper. Healthcare is one of several verticals the fund touches, and within healthcare its relevant surfaces are AI-driven software, clinical workflow tools, and B2B SaaS for the Brazilian provider and payer ecosystem. Founders pursuing biotech, devices, or care delivery should not pursue Big Bets; the fund is software-first and capital-light. The right founder is a Brazilian technical operator, ideally a second-time founder or a senior engineer or PM coming out of a Brazilian or US tech company, who can build an MVP quickly and iterate on real customer feedback without a large team. Big Bets is comfortable being the first institutional check on the cap table and is most useful when paired with strong angel coverage and a credible Seed lead within twelve to eighteen months. Geographic advantage is local network density: founders, hiring channels, and access to the Sao Paulo VC ecosystem, including Kaszek, Monashees, Canary, and similar Tier-1 Brazilian funds for the next round. Best entry path is a warm intro from a Brazilian founder in the ecosystem; the fund’s deal flow runs through trust networks more than cold inbound. Lead the pitch with a sharp wedge, a working prototype, and a believable two-quarter plan to first revenue or strong proxy traction. AI healthcare founders should describe the data asset and the path to a defensible model rather than leading with framework choices. Caveats are sized to the check. Big Bets cannot anchor a real Seed round on its own, so founders need to syndicate carefully, line up a credible Seed lead early, and plan dilution accordingly. Ask the fund directly about reserves, prorata rights, and how it supports portfolio companies into hard Seed-extension scenarios, which are common in Brazil today. Be honest about market timing too: Brazilian healthcare AI buyers move slowly, and a Pre-Seed bet that depends on landing a Bradesco Saude or Hapvida pilot inside twelve months will likely run short of runway. Used as one ticket in a thoughtful early stack, Big Bets is a useful Brazilian partner; used as a lead or as the only sophisticated investor on the cap table, it is structurally undersized for healthcare ambitions.

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  • Avenia

Team

Alexandre Mello
Co-Founder
Luiz Guilherme Manzano
Co-Founder

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Last updated 2026-05-06. Sourced from this fund's published materials.
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