Bread and Butter Ventures

Bread and Butter Ventures is a Minnesota-based seed-stage venture firm with a thesis built around the strengths of the Upper Midwest economy: food and agriculture, healthcare, enterprise B2B SaaS, and water technology. The firm has done healthcare deals from its base in Minneapolis and frequently leverages the regional Mayo Clinic, UnitedHealth Group, and Medtronic ecosystem for diligence and customer development. Public materials are light on AI-specific framing, but the firm has been an active early investor in digital health and healthcare workflow software. Plausible check sizes run 250K to 1M at seed, with selective follow-on, and the firm is comfortable leading or co-leading small rounds. Founders building healthcare AI tools that sell into payers, large self-insured employers, or integrated delivery networks should approach: the firm’s network into UnitedHealthGroup and Optum alone is a real differentiator that few coastal seed funds can match. Founders building consumer wellness, deep biotech, or anything requiring a coastal regulatory or clinical academic-medical-center network should look elsewhere. Entry path is LinkedIn direct outreach to partners (Mary Grove and Brett Brohl have public profiles), or warm introductions through Twin Cities operators and Mayo Clinic-affiliated angels. The firm reads pitches and responds; cold outreach with a clear Midwest GTM angle is workable. Bring evidence of customer traction with regional health systems if you have it; that is the asset they uniquely understand and can amplify.