Cleveland Clinic Ventures

Cleveland Clinic Ventures is the venture and innovation arm of the Cleveland Clinic, one of the most respected academic medical centers in the United States. The mandate is fundamentally strategic: invest in and co-build companies that emerge from Cleveland Clinic’s research, translate clinical insights into commercial products, and create deployment opportunities inside the Cleveland Clinic system and its affiliates. The fund’s portfolio spans medical devices, diagnostics, digital health, clinical AI, and life-sciences tools, with a particular strength in cardiovascular, neurological, and oncology innovations rooted in Cleveland Clinic clinical leadership. For healthcare AI founders, Cleveland Clinic Ventures is the right strategic partner if your product can plausibly be co-developed, validated, or deployed with Cleveland Clinic clinicians — clinical AI in cardiology, neuroimaging, oncology workflows, and ambient documentation are credible fits. Check sizes are typically modest, plausibly $250K to $2M, but accompanied by the meaningful asset of Cleveland Clinic clinical validation, KOL access, and pilot deployment. Stage focus is seed through Series B. Founders who should approach: clinical AI teams that need an academic medical center partnership for validation and reference customer status, particularly in TAs where Cleveland Clinic is a recognized leader. Founders who should not approach: consumer-only health apps, biotech requiring specialist therapeutics syndicates, and teams unwilling to commit to deep clinical co-design. Entry path is warm introduction through Cleveland Clinic clinical leaders, the Innovations team via LinkedIn, or co-investors active in academic-medical-center CVC syndicates. Be prepared for a multi-month engagement before any equity decision.