Lewis & Clark Ventures

Lewis & Clark Ventures operates from St. Louis as a Midwest-focused venture firm putting substantial dollars behind enterprise healthcare software and digital health businesses that have moved past initial product-market fit. The firm is built around the conviction that fast-scaling B2B healthcare companies in the central US deserve growth capital from investors who understand regional health system buyers, employer self-insured purchasing, and the operational realities of serving providers and payers outside the Bay Area or New York. Within healthcare, focus areas include health IT and healthcare software platforms with measurable enterprise traction. Lewis & Clark concentrates capital at Series A and Series B, with check sizes generally between 1M and 5M. That range positions the fund as a meaningful participant in priced rounds led by larger coastal firms or as a regional anchor when a Midwestern company is raising its first institutional round of size. The firm is willing to lead, co-lead, or follow depending on the syndicate, and reserves capital for follow-on participation. Geographic emphasis sits squarely on the Midwest, with St. Louis, Kansas City, Chicago, and surrounding metros forming the heart of pipeline activity, though selective coastal opportunities are considered. Founders engaging Lewis & Clark should be prepared for direct discussions on revenue durability, sales cycles with health systems and payers, and the path to repeatable enterprise contracts. The firm tends to favor capital efficient companies whose growth trajectories can withstand longer sales cycles. Limited public information is available on internal team composition and full portfolio listings.