Madrona backs early-stage and acceleration-stage technology founders, with a strong focus on the convergence of computer science and biology, particularly applied AI, machine learning, and data science in healthcare and life sciences.
About Madrona Venture Group
Madrona Venture Group is a Seattle-based generalist firm with a multi-decade track record of investing across enterprise software, AI infrastructure, and applied vertical software, and selective bets in healthcare technology. Stage focus runs from seed through Series B, with checks typically in the $3M to $15M range and the depth to lead and reserve. Healthcare exposure is opportunistic and concentrated in software rather than therapeutics or devices: clinical workflow AI, life-sciences data tools, and provider operations are the categories where Madrona has historically been comfortable. Physician founders building enterprise health AI, particularly companies with a Pacific Northwest engineering center or ties to the Allen Institute, UW, or Microsoft alumni network, are the right profile. Founders building hardware-heavy devices, consumer health brands, or therapeutics will not find domain conviction. Geographic posture is US-broad with a strong Pacific Northwest tilt. The realistic entry path is a warm introduction from a Madrona portfolio CEO, a Seattle operator, or a co-investing fund; cold inbound is read but partner attention is captured by referred deals. Founders should arrive with a defensible AI thesis, real customer pull, and clean unit economics. Treat Madrona as a serious lead for software-shape healthcare AI companies and one of the more credible partners in the Pacific Northwest ecosystem.
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- Synthesize Bio · 2023
- Archon Bio · 2024
- Ovation · 2025
- Saykara · 2017
- Envisagenics · 2018
- Accolade · 2016
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