Odiseo

Odiseo is a Medellin-based VC focused on B2B software and digital services that modernize traditional Colombian sectors, writing seed and Series A checks in the $250K to $1M range. The fund’s healthcare interest is concentrated in digital health and health IT software with credible enterprise GTM, and the firm is not positioned as an AI-native specialist. The thesis is anchored in the observation that Colombian incumbents across healthcare, logistics, financial services, and agriculture run on outdated software infrastructure, and that founders building modern B2B platforms for those buyers can capture durable revenue with relatively contained capital requirements. The geographic focus is Colombia with selective expansion across the Andean region, and the Medellin headquarters reflects the city’s emergence as one of the more dynamic technology ecosystems in Spanish-speaking Latin America. The right founder profile is a Colombian or Andean founder building B2B software for healthcare providers, payers, or pharmacies, with early commercial traction inside Colombia and a credible path to regional scale into Peru, Chile, and Mexico. The wrong fit is a consumer brand, a deep-tech biotech, or a US-first SaaS company that treats Latin America as an afterthought; Odiseo invests in the region as the primary market. The right entry path is through Medellin and Bogota founder networks, through Ruta N and the broader Medellin technology ecosystem, through Endeavor Colombia connections, and through warm introductions from co-investors at firms like Kaszek, ALLVP, and Polymath. When pitching, lead with the Colombian commercial reality, the buyer profile, the sales motion, and the unit economics, then connect to a regional expansion thesis. Avoid leading with a US-style narrative deck that does not engage with Colombian regulatory and market specifics. Caveats: Odiseo is a smaller regional fund rather than a tier-one Latin American VC, so founders should expect strong local diligence but should plan to bring in larger Series A and growth investors as the company scales. The firm’s healthcare-specialist operating expertise is also generalist rather than deep, so layering clinical-domain advisors onto the cap table is sensible. Use Odiseo when you are building a B2B software business with strong Colombian commercial fundamentals and need a regionally credible early partner.