Samuel Henderson

Samuel Henderson is a Boulder-based solo angel writing $25K to $100K at pre-seed and seed into biotech and pharma. Public data is limited to a LinkedIn profile, so founders should treat this as a personal-conviction angel rather than an institutional vehicle, and there is no listed thesis or portfolio detail to anchor positioning. The Boulder base places him in the Colorado biotech scene, which has notable strength in life sciences manufacturing, bioagriculture, and Anschutz-affiliated translational work, and the network value of an angel here is most concentrated for teams with operations in or near the Front Range. AI is not flagged as a focus, so this is not the right check for a TechBio or computational biology pitch unless there is a clear wet-lab or therapeutic anchor. Check size and structure place him as a single-conviction angel, best used as a small early check and a domain advisor rather than a round leader. Founders most likely to fit are early therapeutics teams with a credible scientific founder, biotech platforms in synthetic biology, bio-manufacturing, or specialty pharma, and any team that benefits from a Colorado-network angel for hiring, lab space, or translational research connections. Devices, digital health, care delivery, and consumer wellness are mismatches. The entry path is a LinkedIn message, ideally warmed by a mutual Colorado biotech or research connection, leading with the science, the founding team’s credentials, and the specific milestone the round funds. Without a referral, expect lower response; with one, conversations move quickly at this check size.