Shoni Health Ventures

Shoni Health Ventures, based at Tel Hashomer adjacent to Sheba Medical Center, is an early-stage fund whose entire identity is wrapped around proximity to one of the world’s leading hospital systems. Sheba is a research-active institution with deep capacity in oncology, cardiology, women’s health, AI, and surgical innovation, and Shoni functions as the venture vehicle most explicitly built to extract and back commercial opportunities arising from that environment.

The fund concentrates on digital health and medical devices at the earliest stages, frequently writing the first institutional check after physician-founders or technical founders working with Sheba clinicians have crystallized a concept. AI is treated as a baseline assumption in modern healthcare investing, and Shoni leans into companies where machine learning is the substantive engine behind clinical decision support, imaging, workflow, or device intelligence. The fund tends to avoid pure consumer wellness, traditional biotech, and software with no clinical anchor.

Check sizes range from $250k to $1M at first investment, with reserves for follow-on participation as companies progress. Stage is pre-seed and seed. Geography is overwhelmingly Israel, with the explicit assumption that companies will commercialize internationally. Shoni regularly syndicates with the broader Israeli healthtech investor base for larger rounds and brings clinical relationships that can shorten validation timelines for portfolio companies.

The team is small and operationally engaged, drawing on backgrounds in healthcare investing, clinical operations, and the Sheba ecosystem. Investment partners typically work hands-on with founders during the formative period, helping shape clinical study designs, regulatory pathway planning, and early commercial conversations. Board involvement is standard at the seed stage.

Founders should approach Shoni with a clearly articulated clinical problem, evidence that physicians have meaningfully shaped the concept, and a defensible technical or product position. Introductions from Sheba clinicians, alumni founders of Sheba-affiliated companies, or other Israeli healthtech investors are the highest-signal path in. The right moment to engage is when a concept has matured past whiteboard, when at least one founder is committed full-time, and when the team has begun to articulate a regulatory pathway and target indication. Founders without a clinical advisor or co-founder should consider that gap before approaching, because Shoni’s value depends on a real partnership with the hospital. Companies focused on consumer health, fintech-adjacent insurance plays, or non-clinical wellness will not find a fit here. For founders building deeply clinical AI or device companies who would benefit from a venture partner physically embedded in a research hospital, Shoni is among the most strategically aligned early-stage backers available.