SignalFire

SignalFire is a San Francisco-based venture firm with a distinctive data-driven sourcing platform and a generalist mandate across early- and growth-stage technology companies, including selective healthcare and life-sciences-adjacent bets. Stage focus runs from seed through later venture rounds, with checks typically in the $2M to $20M range depending on stage and the capacity to lead. Healthcare exposure is opportunistic and concentrated in software-shape companies, AI applied to clinical or operational workflows, and selectively life-sciences tooling rather than therapeutics or hardware-heavy devices. Physician founders building applied AI for healthcare, clinical workflow software with strong commercial pull, or B2B health AI with defensible technical depth are the right profile. Founders building therapeutics, devices, or consumer wellness brands should pitch elsewhere. Geographic posture is US-led with international deal capacity. The realistic entry path is a warm introduction from a SignalFire portfolio CEO, a co-investing seed or Series A fund, or a Bay Area technical operator; the firm’s data-driven model means partners are also responsive to highly thesis-aligned cold outreach. Founders should arrive with defensible product traction, clean unit economics, and an articulated technical and commercial moat. Treat SignalFire as a serious institutional generalist partner for software-shape healthcare AI companies, with a credible lead capability across multiple stages and the data and recruiting infrastructure to support portfolio companies operationally.