Accelerate Pheno System
Overview
The Accelerate Pheno System is a fully automated in vitro diagnostic platform designed for rapid identification (ID) and antimicrobial susceptibility testing (AST) directly from positive blood cultures. It is NOT an AI tool for a physician directory. This system significantly reduces the time required to identify pathogens and determine their susceptibility to various antibiotics, often providing results in hours compared to the days required by conventional methods. Utilizing technologies like fluorescence in situ hybridization (FISH) for identification and morphokinetic cellular analysis (MCA) for susceptibility testing, the Accelerate Pheno System helps clinicians make targeted, life-saving therapy decisions earlier for patients with bacteremia and sepsis. This leads to improved patient outcomes, reduced length of hospital stay, and supports antimicrobial stewardship efforts by enabling optimal antibiotic selection and de-escalation.
Reviewed by Pouyan Golshani, MD — Interventional Radiologist
Key Features
- Rapid Pathogen Identification (ID) in ~90 minutes to 2 hours
- Rapid Antimicrobial Susceptibility Testing (AST) in ~5 to 7 hours
- Directly from positive blood cultures
- Fully automated workflow with minimal hands-on time
- Utilizes Fluorescence In Situ Hybridization (FISH) for ID
- Employs Morphokinetic Cellular Analysis (MCA) for AST
- Provides Minimum Inhibitory Concentration (MIC) results
- Supports targeted antibiotic therapy and de-escalation
- Reduces time to optimal therapy by up to 26.4 hours and length of stay by up to 2.2 days
- Expert rule system for susceptibility interpretation based on FDA/CLSI/EUCAST breakpoints
Use Cases
- Rapid diagnosis of bloodstream infections
- Guiding antibiotic therapy for sepsis patients
- Enhancing antimicrobial stewardship programs
- Reducing hospital length of stay for patients with infections
- Optimizing antibiotic selection and dosage
- Detecting antibiotic resistance faster
What Physicians Need to Know
The Accelerate Pheno System provides rapid, actionable insights into bloodstream infections, delivering pathogen identification in ~90 minutes and full antimicrobial susceptibility results in ~7 hours. This speed is critical for optimizing antimicrobial therapy days faster than conventional methods, potentially reducing patient mortality, length of hospital stay, and the use of broad-spectrum antibiotics. The detailed MICs and AI-assisted interpretation, guided by CLSI/EUCAST breakpoints and expert rules, empower clinicians to make precise, patient-specific treatment decisions, especially for critically ill patients with sepsis.
The system is designed for seamless integration into laboratory workflows with bidirectional LIS connectivity, enabling automated result reporting and critical value alerts. Comprehensive support, including IT and clinical specialists, is provided for implementation, training, data analysis, and ongoing service, ensuring the system is tailored to the institution's unique needs.
Details
| Category | Lab & Diagnostics, Triage & ER/ICU AI |
| Pricing |
Contact vendor for pricing
|
| Deployment | On-premise (laboratory instrument) |
| Compliance | |
| BAA Available | Unknown AI-estimated |
| HIPAA Compliant | Unknown AI-estimated |
| FDA Status |
Yes AI-estimated The Accelerate Pheno System received FDA clearance in 2017. The Accelerate PhenoTest BC Kit, used with the system, received FDA 510(k) clearance (K192665) on September 15, 2020. It is cleared for rapid identification of common bloodstream pathogens and phenotypic antimicrobial susceptibility testing directly from positive blood cultures. |
| Integrations | |
| EHR | Not specified |
| Specialties | Critical Care, Infectious Disease, Laboratory Medicine |
What the Web Says
The Accelerate Pheno System is a fully automated diagnostic device that rapidly identifies bacteria and yeasts and performs antimicrobial susceptibility testing (AST) directly from positive blood cultures. It significantly reduces the time to identification and AST results compared to traditional methods, which can take days. This speed allows physicians to optimize antibiotic therapy sooner, potentially leading to improved patient outcomes, reduced hospital stays, and better antibiotic stewardship.
Overall: PositiveStrengths
- Rapid identification of pathogens (around 1.4 hours)
- Fast antimicrobial susceptibility testing (around 6.6 hours)
- Significantly reduces time to effective antimicrobial therapy
- Improves antibiotic stewardship by enabling targeted treatment
- Potential for reduced length of hospital stay and patient costs
- High sensitivity and specificity for organism identification and AST
Limitations
- May not identify all organisms in polymicrobial infections
- Requires a hospital antimicrobial stewardship program and 24/7 lab operation for optimal impact
- Some studies noted minor, major, and very major errors in AST results, though overall agreement is high
- Limited usefulness for distinguishing certain Gram-positive bacteria like Staphylococcus aureus from S. epidermidis in some cases
- Inclusion of non-blood specimens with high likelihood of polymicrobial infections may result in inferior performance
- Some discordant results highlighted, such as failure to identify certain organisms or suboptimal performance for specific antibiotics
Based on reviews from: Evaluation of the Accelerate Pheno System: Results from Two Academic Medical Centers, Accelerate Pheno System Speeds Up Antibiotic Susceptibility Diagnostics | HCPLive, Effective implementation of the Accelerate Phenou2122 system for positive blood cultures | Journal of Antimicrobial Chemotherapy | Oxford Academic, The Accelerate Phenou2122 system in clinical practice: fast and accurate turnaround for critical results - HealthManagement.org, Evaluation of the Accelerate Pheno System: Results from Two Academic Medical Centers - PMC, Impact on time to active antimicrobial therapy with 24-hour pharmacist review of Accelerate Pheno BC Kit results - PMC, Accelerate Phenou2122 blood culture detection system: a literature review - PubMed, Evaluation of the Accelerate Pheno System for Fast Identification and Antimicrobial Susceptibility Testing from Positive Blood Cultures in Bloodstream Infections Caused by Gram-Negative Pathogens - ASM Journals, Emerging technologies for rapid phenotypic antimicrobial susceptibility testing of clinical isolates of bacteria - PMC, Accelerate Diagnostics, Inc. - Combatting A Crisis - YouTube, Accelerate Phenou2122 Blood Culture Detection System: A Literature Review - Taylor & Francis, The Accelerate Phenou2122 Systemu2014A New Tool in Microbiological Diagnostics of Bloodstream Infections: A Pilot Study from Poland - MDPI, Accelerate Pheno: Rapid Bacterial ID - YouTube, Evaluation of the Accelerate Pheno System for Fast Identification and Antimicrobial Susceptibility Testing from Positive Blood Cultures in Bloodstream Infections Caused by Gram-Negative Pathogens - PubMed, Evaluation of the Accelerate Pheno System for Rapid Identification and Antimicrobial Susceptibility Testing of Positive Blood Culture Bottles Inoculated with Primary Sterile Specimens from Patients with Suspected Severe Infections - PMC
Last updated: 2026-07-17
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