Bunkerhill MAC

by Bunkerhill Health  · Based in United States → — Generative AI for clinical reasoning and action.
Cardiology Radiology
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Regulatory Status Disclosed

Overview

Bunkerhill MAC is the first artificial intelligence algorithm to detect and quantify mitral annular calcification (MAC) on routine, non-gated chest CT scans. It is a key component of Bunkerhill Health’s broader Carebricks platform, which provides generative AI for clinical reasoning and action across health systems. The algorithm addresses a clinically important but often overlooked finding, bringing consistency and scale to the identification of MAC, which is linked to increased cardiovascular risk. By automatically identifying and quantifying MAC, Bunkerhill MAC helps clinicians capture crucial information consistently and at scale, aiding in guiding decision-making and research across cardiology and structural heart care. The Carebricks platform, where Bunkerhill MAC is available, enables health systems to design and deploy AI-powered, end-to-end workflows that integrate seamlessly with EHRs to improve care and efficiency without adding workload for clinicians.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • AI-powered detection and quantification of Mitral Annular Calcification (MAC)
  • Analyzes routine, non-gated chest CT scans
  • Identifies patients at increased cardiovascular risk
  • Integrates with the Carebricks generative AI platform for clinical reasoning and action
  • Supports automated workflows for follow-up and care coordination
  • Developed and validated through a multi-institutional research consortium
  • Seamless integration with existing EHRs and clinical systems

Use Cases

  • Opportunistic screening for mitral annular calcification and associated cardiovascular risk
  • Early identification of patients who may benefit from further cardiovascular evaluation or treatment
  • Streamlining clinical workflows for cardiovascular risk assessment
  • Guiding decision-making and research in cardiology and structural heart care
  • Automating patient follow-up and care coordination for at-risk individuals
  • Improving patient outcomes and operational efficiency in healthcare systems

What Physicians Need to Know

Cardiac CT/MRI Analysis
Bunkerhill MAC is an FDA-cleared AI algorithm designed to detect and quantify mitral annular calcification (MAC) on routine, non-gated chest CT scans, a first-of-its-kind approval. The platform also includes FDA-cleared algorithms for automated coronary artery calcium (CAC) scoring (iCAC for routine CT, CAC for gated cardiac CT) and quantification of aortic valve calcification (Bunkerhill AVC) on non-contrast chest CTs, aiding in the early detection of coronary artery disease and aortic stenosis risk. Additionally, it offers an FDA-cleared algorithm for abdominal aortic quantification on CT scans.
ECG/EKG Analysis Capability
Bunkerhill Health offers an FDA-cleared AI algorithm, ECG-EF, which detects reduced left ventricular ejection fraction (LVEF) from routine 12-lead ECGs. This algorithm uses machine learning to analyze ECG data for early identification of patients at risk for heart failure.
Heart Failure Risk Prediction
The Bunkerhill MAC algorithm identifies mitral annular calcification, which is recognized as an independent risk factor for heart failure and is linked to increased cardiovascular risk and procedural complications. The ECG-EF algorithm directly aids in heart failure risk prediction by detecting reduced LVEF from routine ECGs, enabling earlier identification of high-risk patients.
Coronary Artery Assessment
Bunkerhill Health's iCAC algorithm provides automated, real-time Agatston scoring and MESA risk percentiles from non-gated, non-contrast chest CT scans for early detection and risk stratification of coronary artery disease. They also partner with companies like Cleerly to enhance coronary artery disease detection and risk assessment.
Cardiac Monitoring Integration
Bunkerhill MAC and other Bunkerhill Health AI algorithms are integrated into the Carebricks generative AI platform. Carebricks seamlessly embeds AI models into existing clinical workflows, analyzing patient data and automating next steps such as notifying care teams and routing referrals. It is currently deployed in over 150 sites of care in the United States, including major health systems like Cleveland Clinic and Mayo Clinic.
AHA/ACC Guideline Alignment
Bunkerhill's algorithms support guideline-aligned cardiology follow-up by cross-checking ASCVD risk factors for coronary artery calcium findings and coordinating surveillance for abdominal aortic enlargement. The detection of aortic valve calcification also helps identify patients who may warrant evaluation for aortic stenosis, aligning with clinical guidelines.
Real-Time Alert Capability
The Carebricks platform, which hosts Bunkerhill MAC, is designed to address actionable incidents and automate next steps, including notifying care teams. Workflows can be configured to provide on-screen and printed notifications for critical values and to alert primary clinicians and cardiology for follow-up based on AI findings from CT scans.
Physician Tip

Bunkerhill Health's AI tools, including Bunkerhill MAC, offer significant value by opportunistically detecting critical cardiovascular risk factors from routine imaging studies like non-gated chest CTs and ECGs that patients already receive. This can lead to earlier identification of conditions like mitral annular calcification, coronary artery disease, aortic valve calcification, and reduced ejection fraction, which might otherwise be missed or underreported. Physicians should leverage these tools as decision support to standardize preventive evaluation, guide further diagnostic workup (e.g., echocardiography for low LVEF), and tailor patient care and procedural planning. The seamless integration into existing workflows via the Carebricks platform can streamline processes, reduce manual workload, and facilitate timely follow-up, ultimately improving patient outcomes and potentially reducing healthcare costs.

Bunkerhill Health's AI algorithms, including Bunkerhill MAC, are delivered through its flagship generative AI platform, Carebricks. This platform is designed for deep integration into health systems' existing clinical workflows. Carebricks can analyze structured and unstructured patient data, apply AI-powered reasoning, and automate next steps. This includes bidirectional communication with cardiology information systems (like MUSE) and Electronic Medical Records (EMRs) or DICOM gateways, supporting HL7 and DICOM standards. The platform enables customized workflows for tasks such as notifying care teams, routing referrals, streamlining prior authorization, and automating registry submissions, without disrupting current clinical practices.

Details

Category Cardiology AI, Clinical Decision Support & Reference
Pricing Contact for pricing
DeploymentCloud-based, integrated with existing EHRs and clinical systems via Carebricks platform.
Compliance
BAA AvailableUnknown AI-estimated
HIPAA CompliantUnknown AI-estimated
FDA Status Yes AI-estimated

Bunkerhill MAC received U.S. Food and Drug Administration (FDA) 510(k) clearance (K250662) on October 8, 2025, as the first artificial intelligence algorithm to detect and quantify mitral annular calcification (MAC) on routine, non-gated chest CT scans.
Integrations
EHR Not specified
Specialties Cardiology, Radiology

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Press & Coverage

Applied Radiology
Bunkerhill Health Secures FDA Clearance for AI Tool to Detect Mitral Annular Calcification on Routine CT Scans
Bunkerhill Health received FDA clearance for Bunkerhill MAC, an AI algorithm that detects and quantifies mitral annular calcification (MAC) on routine CT scans, marking a first-of-its-kind approval for identifying this cardiovascular risk marker.
2025-10
TNW
Bunkerhill raises $55M for hospital-built clinical AI agents - TNW
Bunkerhill Health closed a Series B funding round, raising $55 million to further develop its Carebricks platform, which allows health systems to build and deploy their own clinical AI agents.
2026-07
Bunkerhill Health (Press Release)
Bunkerhill Health Raises $55 Million to Help Health Systems Turn Their Best Ideas into Reality
Bunkerhill Health announced the close of its Series B funding round, securing $55 million to expand its Carebricks agentic AI platform, which enables health systems to create and deploy AI agents for various clinical, operational, and administrative tasks.
2026-07
Medical Product Outsourcing
FDA OKs 1st AI Algorithm to Detect Mitral Annular Calcification
Bunkerhill Health obtained FDA clearance for Bunkerhill MAC, the first AI algorithm designed to automatically identify and quantify mitral annular calcification (MAC) on routine chest CT scans.
2025-10
PR Newswire
Bunkerhill Health Receives FDA Clearance for the First-Ever AI Solution to Detect Mitral Annular Calcification
Bunkerhill Health announced FDA clearance for Bunkerhill MAC, an AI algorithm that detects and quantifies mitral annular calcification on non-gated chest CT scans, addressing an often-overlooked cardiovascular risk factor.
2025-10
Diagnostic Imaging
FDA Clears CT-Based AI For Detection of Mitral Annular Calcification | Diagnostic Imaging
The FDA granted 510(k) clearance for Bunkerhill MAC, an AI algorithm for detecting and quantifying mitral annular calcification on non-gated chest CT scans, a condition linked to elevated cardiovascular risks.
2025-10
AuntMinnie
U.S. FDA clears Bunkerhill Health's CT software | AuntMinnie
Bunkerhill Health received FDA clearance for its AI algorithm, Bunkerhill MAC, which detects and quantifies mitral annular calcification on non-gated chest CT scans, a condition associated with increased cardiovascular risk.
2025-10
Bunkerhill Health (Press Release)
Bunkerhill Health and Cleerly Announce Strategic Partnership to Advance Noninvasive Cardiovascular Care
Bunkerhill Health and Cleerly formed a strategic partnership to expand access to their FDA-cleared technologies for coronary artery disease detection and risk assessment, aiming to identify at-risk patients earlier.
2025-03

Videos

Product demos, reviews, and walkthroughs for Bunkerhill MAC.

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Frequently Asked Questions

Bunkerhill MAC is designed to seamlessly integrate into existing clinical workflows by automatically identifying and quantifying mitral annular calcification (MAC) on routine, non-gated chest CT scans that patients already receive for other indications. This allows clinicians to consistently capture an often-overlooked cardiovascular risk factor at scale, aiding in risk stratification and guiding decision-making in cardiology and structural heart care.
Bunkerhill MAC has received U.S. Food and Drug Administration (FDA) clearance as the first AI algorithm to detect and quantify mitral annular calcification. While specific details on HIPAA compliance weren't explicitly detailed in the provided snippets, Bunkerhill Health's Carebricks platform, which hosts Bunkerhill MAC, is used by major health systems like Cleveland Clinic and Mayo Clinic, implying adherence to industry standards for patient data handling.
Bunkerhill MAC is unique as the first FDA-cleared AI model specifically designed to detect and quantify mitral annular calcification on routine, non-gated CT scans, a condition often missed or inconsistently reported. Unlike traditional methods that might require specialized cardiac imaging, it leverages existing imaging data to provide consistent, scalable insights into this important cardiovascular risk factor without disrupting existing clinical workflows.
The provided search results do not explicitly specify the exact pricing model or cost structure for implementing Bunkerhill MAC or the Carebricks platform. Generally, AI solutions for healthcare often involve subscription-based licensing, per-use fees, or enterprise-level agreements, which would typically be discussed directly with Bunkerhill Health. However, Bunkerhill Health has secured a CMS reimbursement pathway for AI cardiovascular analysis, including coronary artery calcium and aortic valve calcium on chest CT scans, which may influence cost considerations.
While Bunkerhill MAC offers significant advantages in detecting MAC, the search results do not explicitly detail its specific limitations or potential biases. As with any AI tool, factors such as image quality, patient demographics, and the specific characteristics of the training data used in its development could potentially influence its performance in diverse clinical populations.
Bunkerhill MAC is part of Bunkerhill Health's broader Carebricks generative AI platform, which is designed to apply various AI models across the full scope of patient data. Carebricks can also assist with referral prioritization, address actionable incidents, automate care coordination, and has FDA-cleared algorithms for detecting and quantifying coronary artery calcium (CAC) and aortic valve calcium (AVC) on routine chest CTs.

Compare Bunkerhill MAC

VS
Bunkerhill MAC vs EchoNext
Cardiology AI Adjacent · 70/100
Both Bunkerhill MAC and EchoNext are FDA-cleared AI tools in cardiology, offering clinical decision support. Bunkerhill MAC focuses on detecting and quantifying mitral annular calcification from CT scans,…
VS
Bunkerhill MAC vs PMcardio
Cardiology AI Adjacent · 65/100
Both Bunkerhill MAC and PMcardio are AI-powered cardiology tools providing clinical decision support. However, Bunkerhill MAC focuses on detecting and quantifying mitral annular calcification from CT scans, primarily…
VS
Bunkerhill MAC vs KardiaPro
Cardiology AI Adjacent · 65/100
Bunkerhill MAC and KardiaPro are adjacent tools within cardiology AI, both offering clinical decision support. Bunkerhill MAC focuses on identifying cardiovascular risk through CT scan analysis for mitral…
VS
Bunkerhill MAC vs SENSICARDIAC
Cardiology AI Adjacent · 65/100
While both tools leverage AI in cardiology, they address distinct diagnostic needs. Bunkerhill MAC focuses on identifying cardiovascular risk through the detection and quantification of mitral annular calcification…

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Suggest an Edit → | Last Verified: 2026-04-17 | First Added: 2026-04-17
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