Flatiron Health OncologyCloud

by Flatiron Health  · Based in United States →Reimagining the infrastructure of cancer care
Hematology Oncology

Not publicly available for the full oncologycloud suite; api pricing details are available.

Overview

Flatiron Health provides comprehensive solutions across the oncology industry to learn from and improve every person’s experience with cancer. Their technology and evidence are relied upon by clinicians, researchers, and regulators to accelerate drug development and access, power smarter care, and transform possibilities into results. The platform includes an oncology-specific Electronic Health Record (EHR) system, OncoEMR®, which offers customizable clinical decision support (Flatiron Assist™), instinctive workflows, up-to-date treatment guidelines, and actionable data to enhance patient experience, streamline operations, and increase revenue. Flatiron Health is also a leader in generating robust real-world evidence and insights by aggregating de-identified patient data from diverse care settings and leveraging advanced natural language processing, machine learning, and large language models for data extraction and analysis.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • Oncology-specific Electronic Health Record (OncoEMRu00ae)
  • Real-world data aggregation from diverse care settings
  • AI-powered data extraction using NLP, ML, and LLMs from unstructured clinical notes
  • Customizable clinical decision support (Flatiron Assistu2122)
  • Patient matching for clinical trials
  • Generation of robust real-world evidence and insights
  • Integration with precision oncology portfolios (e.g., Abbott's OncoEMRu00ae integration)
  • Secure, cloud-based trusted research environment for data sharing
  • FHIRu00ae APIs for data exchange and custom workflows
  • Longitudinal, patient-level data collection and curation

Use Cases

  • Accelerating drug development and access
  • Powering smarter care for cancer patients
  • Generating robust real-world evidence for research and regulatory purposes
  • Improving patient experience and streamlining operations in cancer centers
  • Supporting informed treatment decisions at the point of care
  • Facilitating ordering and viewing of precision oncology tests within clinical workflow

What Physicians Need to Know

Evidence Base (guidelines, literature scope)
Flatiron Assist leverages National Comprehensive Cancer Networku00ae (NCCNu00ae) Clinical Practice Guidelines in Oncology (NCCN Guidelinesu00ae) and NCCN Order Templatesu00ae. It also incorporates First Databank drug information. The broader Flatiron platform integrates real-world data from EHRs, lab, and medical claims, and genomic data from partners like Caris Life Sciences and Foundation Medicine.
Clinical Validation Studies
A study on Flatiron Assist for non-small cell lung cancer (NSCLC) treatment orders at 11 community practice sites showed 69% tool utilization and 92% guideline concordance for regimens ordered via the tool. Flatiron also published the peer-reviewed VALID Framework for evaluating the quality and reliability of AI-extracted real-world oncology data.
Alert Fatigue Management
The system is designed for seamless integration into clinical workflows, aiming to reduce cognitive burden and streamline processes. Flatiron Assist uses machine learning to surface NCCN guidelines and site-preferred pathways, which helps alleviate administrative tasks and allows clinicians to focus on patient care.
Override Rate Data
Flatiron Assist has demonstrated over 90% NCCNu00ae concordance and a 58% reduction in unique regimens ordered across cancer centers. Prescriber-reported reasons for non-concordant regimens included 'physician choice' (59%), 'patient status' (12%), and 'newly published evidence' (10%).
Drug Interaction Checking
OncoEMRu00ae includes embedded First Databank drug information, which typically provides comprehensive drug interaction checking capabilities.
Guideline Update Frequency
Flatiron Assist's clinical guidelines are continually updated. NCCN Guidelines, a primary source, are updated within two weeks of practice-changing developments. Flatiron's content team monitors new FDA approvals and NCCN Guidelines updates, pushing content updates monthly.
Clinical Workflow Integration
Flatiron Assist is a SMARTu00ae on FHIRu00ae application that launches directly from the patient's chart in EHRs like Epic, eliminating duplicate data entry. OncoEMRu00ae integrates with hundreds of tools, including molecular profiling labs (Caris Life Sciences, Foundation Medicine, Abbott, Natera) and State Prescription Drug Monitoring Programs (PDMP).
Decision Audit Trail
The system documents and reports various quality metrics, and Flatiron's real-world testing includes examining audit logs within the certified health IT module to track the frequency and success of actions.
Physician Tip

Leverage Flatiron Assist's direct integration with NCCN Guidelines and clinical trial matching to ensure evidence-based treatment selection and streamline prior authorizations. Utilize the seamless EHR integration to minimize manual data entry and enhance workflow efficiency. Pay attention to the reported concordance rates and reasons for non-concordance to understand and address variations in care. The system's ability to integrate genomic data from various labs can significantly aid in precision medicine decisions.

Flatiron OncologyCloud offers robust integrations, notably with major Electronic Health Records (EHRs) such as Epic via SMART on FHIR, ensuring data flow and reducing administrative burden. It also features extensive integrations with leading molecular profiling laboratories (e.g., Caris Life Sciences, Foundation Medicine, Abbott, Natera) to incorporate genomic data directly into the clinical workflow, enhancing precision oncology capabilities. Integrations also extend to State Prescription Drug Monitoring Programs (PDMP) for compliance.

Details

Category Clinical Decision Support & Reference, Oncology AI
Pricing Not publicly available for the full oncologycloud suite; api pricing details are available.
  • Flatiron R4 FHIR® APIs for USCDI v3 data elements are included within the cost of an OncoEMR® subscription
  • For use cases requiring an OncoEMR® end user to launch a SMART-on-FHIR® application directly from OncoEMR® (EHR Launch), there is an integration fee of $3,000
  • Flatiron does not impose a fee on patients or application developers for accessing patient health information via SMART-on-FHIR® applications
DeploymentCloud-based
Compliance
BAA AvailableUnknown AI-estimated
HIPAA CompliantUnknown AI-estimated
FDA Status Unknown AI-estimated

Flatiron Health's real-world data (RWD) has supported the U.S. Food and Drug Administration (FDA)'s approvals for new dosing regimens, such as for ERBITUX®, and has been used in regulatory filings for drugs like Lumakras. Flatiron Health also maintains ongoing research collaborations with the FDA to explore analytic approaches and methods for using real-world evidence to inform regulatory decision-making in oncology.

Integrations
EHR Not specified
Specialties Hematology, Oncology

What the Web Says

Flatiron Health's OncologyCloud is a comprehensive, cloud-based software suite designed for cancer care providers, integrating an Electronic Health Record (OncoEMR), billing (OncoBilling), analytics (OncoAnalytics), and clinical trials (OncoTrials) to streamline workflows and enhance patient care. The platform aims to organize global oncology information and transform cancer care delivery by providing deeper insights from diverse and siloed oncology data. It is used by over 2,000 clinicians and supports the treatment of approximately one in five U.S. cancer patients.

Overall: Mixed

Strengths

  • Oncology-specific design with intuitive workflows and customizable templates.
  • Comprehensive oncology resources, including AJCC staging content, NCCN Order Templates, and First Databank drug information.
  • OncoAnalytics helps identify and recover underbilled or missed charges, and provides detailed clinical and business insights.
  • Facilitates participation in clinical trials and contributes to oncology research.
  • User-friendly interface and ease of learning for basic functionalities.
  • Strong employee sentiment regarding mission-driven work, collaborative culture, and work-life balance for some roles.

Limitations

  • Poor reporting functionality and limited access to data fields.
  • Integration challenges with other systems.
  • Learning curve for mastering advanced features.
  • Some users report the system can be slow, glitchy, and not fully compatible with Apple products.
  • Concerns about leadership, communication, and limited advancement opportunities from some employees.
  • Low pay and inconsistent work availability for some part-time roles.

Based on reviews from: Flatiron Health u2013 Using AWS to Help Improve Cancer Treatment, Flatiron Health Unveils New Features and Enhancements to the OncoCloud Software Platform, What's It Like to Work at Flatiron Health? - Built In, OncologyCloud EHR Software - Pricing, Demo & Comparison Tool, Working as an Oncology Data Specialist at Flatiron Health in Remote: Employee Reviews | Indeed.com, OncoEMR Reviews 2026: Details, Pricing, & Features - G2, Flatiron Health Employee Reviews - Comparably, How well does Flatiron Health work? - Quora, Flatiron Health was acquired for $2.0B; isn't it just a curated annotations platform? - Reddit, Flatiron OncoEMR Reviews, Pricing, Features & Integrations - Elion Health, Flatiron Health OncoEMR: Specialized EHR for Oncology Care, Flatiron Health EMR 2019 Pricing, Reviews & Demo - ehrreviews.com, Thoughts on Flatiron Health vs. other offers : r/cscareerquestions - Reddit, Working at Flatiron Health: 74 Reviews | Indeed.com, OncoEMR Reviews 2026. Verified Reviews, Pros & Cons | Capterra, OncoEMR Software Pricing, Alternatives & More 2026 | Capterra, Flatiron Health reputation in tech industry? : r/cscareerquestions - Reddit, Flatiron Health : r/Career_Advice - Reddit, Flatiron Health Culture | Comparably, Flatiron Health vs Well known tech company : r/cscareerquestions - Reddit, Why Flatiron is betting on data quality, not hype, to power the next era of cancer care, Working at Flatiron Health: Employee Reviews about Work-life balance | Indeed.com

Last updated: 2026-07-27

Ratings & Reviews

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Press & Coverage

ITQlick
OncoEMR vs OrdinalData (2026): Pricing & Hidden Fees Revealed - ITQlick
Flatiron Health, established in 2012, developed the Flatiron Health OncologyCloud software to help oncologists and researchers manage and analyze clinical data. OncoEMR, part of the OncologyCloud suite, is rated higher than OrdinalData in features and overall score, though OrdinalData has a lower starting price.
2026-06
Flatiron Health
Flatiron Health brings 49+ research acceptances and next-generation capabilities to ASCO 2026
Flatiron Health is presenting 49+ research acceptances and next-generation capabilities at ASCO 2026, focusing on expanding point-of-care solutions in oncology and using data to improve cancer care through machine learning, AI, and real-world evidence.
2026-05
Flatiron Health
Flatiron Health research on AI-driven cancer progression extraction presented at AACR Special Conference in Cancer Research: Artificial Intelligence and Machine Learning 2025
Flatiron Health presented research on AI-driven cancer progression extraction at the AACR Special Conference in Cancer Research: Artificial Intelligence and Machine Learning 2025. This highlights their ongoing work in leveraging AI for oncology research.
2025-11
EHR in Practice
Top oncology EHRs to kickstart your selection shortlist - EHR in Practice
The Flatiron Health OncologyCloud platform, including OncoEMR, offers an industry-leading electronic medical record for oncology, advanced analytics, a patient portal, and integrated billing management. It is highlighted for its interoperability with Varian's ARIA Oncology Information System and integrated pathways from organizations like Via Oncology.
2022-08
AACR Journals
Obstacles, Opportunities and Priorities for Advancing Metastatic Breast Cancer Research - AACR Journals
Flatiron Health's OncologyCloud is mentioned as one of the artificial intelligence systems working towards integrating information from in vitro and in vivo model systems to better understand metastatic breast cancer. The article emphasizes the need for data sharing and innovative model systems in cancer research.
2017-07
AWS News Blog
Flatiron Health u2013 Using AWS to Help Improve Cancer Treatment
Flatiron Health leveraged AWS to bring its OncologyCloud software suite, including OncoAnalytics, to market faster, benefiting from AWS's compliance standards, automation tools, and range of services for secure and scalable data management.
2016-03
Flatiron Health
West Cancer Center Chooses Flatiron Health's OncoEMR and OncoAnalytics to Support High Quality Patient Care
West Cancer Center selected Flatiron Health's OncoEMR and OncoAnalytics, part of the OncologyCloud suite, to enhance evidence-based care, support alternative payment models, and manage clinical workflows. OncoEMR is a cloud-based EHR for medical oncology, and OncoAnalytics provides insights from various data systems.
2016-03
Flatiron Health
Flatiron Health Announces Strategic Relationships with Celgene and Amgen to Further Advance Personalized Medicine for Cancer Patients and Accelerate Clinical Research
Flatiron Health expanded its relationships with Celgene and Amgen to accelerate clinical research, advance personalized medicine, and enhance cancer treatment options. Celgene will continue to use Flatiron Health's OncologyCloud platform for patient access tools and real-world data.
2016-04

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Frequently Asked Questions

Flatiron Assist integrates with the EHR to provide evidence-based treatment options, including National Comprehensive Cancer Networku00ae (NCCN) Guidelines and relevant clinical trials, at the point of care. It helps streamline regimen selection, prior authorization, and supports adherence to best clinical practices without disrupting daily workflows.
Flatiron Health OncologyCloud, through components like OncoEMRu00ae and OncoAnalyticsu2122, is designed to support compliance with evolving regulatory requirements, such as those for the Oncology Care Model (OCM) and other value-based care programs. It offers automated reporting for quality measures and embeds evidence-based regimens and pathways to aid adherence to guidelines.
Challenges can include ensuring robust data integrity, as AI models are dependent on the quality of their training data, and addressing the potential for bias in AI tools if not trained on diverse datasets. Additionally, integrating with disparate clinical workflows and cleansing unstructured data can be complex.
Other oncology-specific EHR and practice management systems include CureMD, ARIA Oncology Information System (Varian), MOSAIQ (Elekta), iKnowMed Generation 2 (McKesson), and Medsym Solutions. These systems offer varying features for clinical documentation, practice management, and billing.
Flatiron Health OncologyCloud generally follows an enterprise pricing model, which is customized based on the practice's size and specific needs. It typically involves a one-time implementation fee for installation, plus annual subscription fees covering software licenses, customer support, and upgrades.
Flatiron Assist, a key clinical decision support tool, is designed as a SMARTu00ae on FHIRu00ae application that integrates directly with EHRs like Epic, launching from the patient's chart to eliminate duplicate data entry. OncoEMRu00ae also integrates with hundreds of other tools and programs, including molecular profiling services and state Prescription Drug Monitoring Programs (PDMPs), to create seamless workflows.
Flatiron OncologyCloud, particularly through OncoAnalyticsu2122, aggregates EHR, practice management, and billing data to provide actionable insights via dashboards. This helps practices identify missed charges, understand drug utilization, track performance for value-based care models, and identify potential clinical trial candidates.

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Suggest an Edit → | Last Verified: 2026-04-22 | First Added: 2026-04-22

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