HealthOST

by Nanox.AI  · Based in Israel → — AI-powered bone health analysis for early detection of osteoporosis.
Endocrinology Radiology Rheumatology

Contact vendor for pricing information.
Regulatory Status Disclosed

Overview

HealthOST by Nanox.AI is an artificial intelligence-based image processing software designed to assist in the qualitative and quantitative analysis of the spine. It is developed for radiologists and clinicians working in musculoskeletal health, orthopedics, and primary care settings. The software is indicated for use in patients aged 50 and older undergoing CT scans of the chest or abdomen for any clinical indication.

The tool fits into existing clinical workflows by running in parallel with standard image storage and processing. It opportunistically analyzes routine CT scans that are not specifically performed for osteoporosis assessment. The algorithm automatically populates findings directly into the radiology report to support clinical decision-making and patient risk assessment.

Notable capabilities of HealthOST include:

  • Vertebral Labeling: Automatic labeling of the T1-L4 vertebrae.
  • Height Loss Measurement: Quantitative measurement of height loss in each vertebra from T1 to L4 to detect potential vertebral compression fractures (VCF).
  • Bone Attenuation Measurement: Measurement of mean Hounsfield Units (HU) within a volume of interest from T11 to L4 to assess bone density and identify low bone mineral density (BMD).

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • Automated vertebral compression fracture detection
  • Estimation of bone mineral density from CT scans
  • Vertebrae labeling and segmentation (T1-L4)
  • Quantitative vertebral height loss measurement (T1-L4)
  • Triaging and prioritization of studies for radiologist review
  • Visual overlays highlighting suspicious vertebrae on CT images
  • Structured result generation and measurements
  • Batch processing of CT series including spine
  • Clinical decision support for osteoporosis risk
  • Performance and throughput monitoring and analytics

Use Cases

  • Early detection of osteoporosis and musculoskeletal disease
  • Identification of patients at risk for vertebral compression fractures and low bone density
  • Assisting clinicians in diagnosis and treatment planning for bone health
  • Improving radiology workflow efficiency by automating analysis of routine CT scans
  • Guiding preventive care pathways for at-risk patients
  • Leveraging existing chest and abdominal CT scans for incidental findings

What Physicians Need to Know

Key Capabilities
HealthOST provides fully automated qualitative and quantitative analysis of the spine from routine CT scans (chest, abdomen, pelvis) to detect vertebral compression fractures (VCFs) and low bone mineral density (BMD). It labels T1-L4 vertebrae, measures vertebral height loss (T1-L4), and assesses bone attenuation (T11-L4) using Hounsfield Units. The tool also offers triaging, visual overlays, structured reporting, and clinical decision support for osteoporosis risk.
Clinical Utility
This AI solution aids clinicians in the early identification of patients at risk for osteoporosis and musculoskeletal diseases by leveraging existing CT scans, thus requiring no additional imaging or radiation. It helps prevent life-altering fractures by detecting VCFs and low BMD that might otherwise go unnoticed, significantly improving early diagnosis and enabling timely preventive care.
Integration Options
HealthOST seamlessly integrates with existing Picture Archiving and Communication Systems (PACS), Radiology Information Systems (RIS), Electronic Health Records (EHR) via standard interfaces, DICOM storage/viewers, and reporting systems. It supports DICOM, HL7 v2, and FHIR data standards, with deployment options for SaaS and on-premise.
Compliance Status
HealthOST has received FDA 510(k) clearance (April 2022) and EU MDR CE mark certification (June 2025). It is designed and manufactured under Quality System Regulations (21 CFR u00a7 820) and is HIPAA and GDPR compliant.
Pricing Model
The pricing model is subscription-based. Specific pricing details require direct contact with the vendor. A reimbursement pathway exists for its use with CPT Code: 0691T.
User Experience
The software operates automatically without human intervention, integrating into existing radiology workflows to provide automated detection and report generation. Results are presented via Secondary Capture within the PACS environment, with visual overlays highlighting suspicious findings.
Support Quality
Support is available through multiple channels including email, phone, ticketing, a client portal (Zendesk), and a web contact form. Training resources include documentation, webinars, live online demos, and onsite implementation support.
Implementation Complexity
HealthOST is designed for seamless integration with existing PACS and radiology workflows. It offers flexible deployment options (SaaS or on-premise) and requires DICOM-compatible CT images, with integration via Nanox.CLOUD or an on-premise connector.
Evidence Base
FDA 510(k) clearance was based on substantial equivalence. The AI-enabled Detection of OsteoPorosis for Treatment (ADOPT) study, which evaluated HealthVCF (predecessor) and HealthOST, identified over 3,450 new VCF patients from 37,220 routine CT scans. A clinical validation study (Mathew et al. 2025) showed 92.0% sensitivity for VCF detection at a 20% height loss threshold. NICE has recommended it for Early Value Assessment in UK NHS hospitals.
Physician Tip

Consider HealthOST for opportunistic screening of osteoporosis and vertebral compression fractures in patients aged 50 and over undergoing routine chest or abdominal CT scans. Its automated analysis and integration into existing PACS can significantly enhance early detection without additional imaging burden. Be aware that while it offers high sensitivity for screening, the specificity may lead to some false positives, necessitating a structured follow-up workflow. Leverage the provided quantitative data to support clinical decision-making and facilitate communication with orthopedic specialists.

HealthOST's robust integration capabilities with PACS, RIS, and EHR systems via DICOM, HL7 v2, and FHIR standards are key for seamless workflow adoption. Evaluate the SaaS vs. on-premise deployment options based on your institution's IT infrastructure and data residency requirements. Utilize the optional integration services for customized reporting and workflow optimization to maximize the tool's utility within your clinical environment.

Details

Category Endocrinology & Metabolic AI, Radiology & Imaging AI
Pricing Contact vendor for pricing information. — Subscription model.
DeploymentSaaS, on-prem (local/PACS deployment), cloud (US and EU hosting region options).
Compliance
BAA AvailableUnknown AI-estimated
HIPAA CompliantUnknown AI-estimated
FDA Status 1 AI-estimated

HealthOST received FDA 510(k) clearance (K213944) on April 22, 2022. It is cleared for qualitative and quantitative analysis of the spine from CT images to support clinicians in the evaluation and assessment of musculoskeletal disease of the spine.

Integrations
EHR Not specified
Specialties Endocrinology, Radiology, Rheumatology

What the Web Says

HealthOST is an AI-powered software developed by Nanox.AI that assists physicians in analyzing CT scans for vertebral compression fractures (VCF) and low bone mineral density (BMD), key indicators of osteoporosis. It is designed to integrate seamlessly into existing radiology workflows and PACS systems, providing automated qualitative and quantitative analysis of the spine. The software has received FDA 510(k) clearance and EU MDR CE Mark certification, enabling its commercialization in the US and Europe.

Overall: Positive

Strengths

  • Helps identify patients at risk of osteoporosis and vertebral compression fractures from routine CT scans, without requiring additional imaging or radiation.
  • Provides automated qualitative and quantitative analysis of the spine, including vertebral height loss and bone mineral density measurements.
  • Integrates seamlessly with existing Picture Archiving and Communication Systems (PACS), minimizing disruption to radiology workflows.
  • Can lead to earlier diagnosis and intervention for musculoskeletal diseases, potentially improving patient outcomes.
  • Offers a reimbursement pathway with CPT Code: 0691T for AI-enhanced radiology workflow.
  • Potential for cost reduction in chronic disease management and increased revenue due to higher patient retention.

Limitations

  • No specific cons were found in the provided search results from physicians, healthcare IT, tech reviewers, Reddit, G2, or Capterra regarding HealthOST.
  • General challenges with new healthcare software implementations can include upfront costs and the need for staff training.

Based on reviews from: Diagnostic Imaging, Nano-X Imaging LTD., TestDynamics, Blackford Analysis, G2, Capterra

Last updated: 2026-07-18

Ratings & Reviews

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Press & Coverage

Imaging Technology News
Nanox Announces FDA Clearance for HealthOST Device
Nano-X Imaging LTD's subsidiary, Nanox.AI, received FDA 510(k) clearance for its HealthOST device, an AI software that analyzes CT scans to help clinicians evaluate musculoskeletal diseases like osteoporosis. This marks Nanox.AI's tenth FDA clearance and its second for a vertebral compression fracture device.
2022-04
Business Wire
Nanox Announces FDA Clearance for HealthOST Device, an AI Software Measuring Vertebral Compression Fractures and Low Bone Density, Which are Often Associated with Osteoporosis
Nanox.AI, a subsidiary of NANO-X IMAGING LTD, announced FDA 510(k) clearance for its HealthOST AI software, designed to provide qualitative and quantitative analysis of the spine from CT images for musculoskeletal disease assessment, particularly osteoporosis. The software aims to improve the identification of patients at risk for osteoporosis and related fractures.
2022-04
Diagnostic Imaging
AI Software HealthOST Gets FDA 510(k) Clearance for Enhanced CT Analysis of Vertebral Compression Fractures
Nanox's HealthOST AI software received FDA 510(k) clearance for its ability to provide enhanced qualitative and quantitative analysis of spine CT images, aiding in the assessment of musculoskeletal diseases like osteoporosis and detecting vertebral compression fractures. The software aims to address the high rate of misdiagnosed or unreported compression fractures.
2022-04
GuruFocus
NNOX Secures EU MDR CE Mark for HealthOST, Enhancing Bone Health
Nano-X Imaging Ltd's subsidiary, Nanox AI, obtained EU MDR CE mark certification for HealthOST, its bone health evaluation software. This approval allows for commercialization across Europe, building on its earlier FDA 510(k) clearance in April 2022.
2025-06
Nano-X Imaging LTD. (Press Release)
Nanox Receives MDR CE Mark for HealthOST, an Advanced AI-Powered Software for Spine Assessment
Nanox AI Ltd, a subsidiary of NANO-X IMAGING LTD, announced it received EU MDR CE mark certification for HealthOST, an AI-powered software for bone health analysis. This certification enables its commercialization in Europe and ensures compliance with high regulatory standards for medical software.
2025-06
PMC (PubMed Central)
Clinical Validation of Commercial AI Software for the Detection of Incidental Vertebral Compression Fractures in CT Scans of the Chest and Abdomen
This retrospective study clinically validated the Nanox.AI HealthOST software for detecting incidental vertebral compression fractures (VCFs) on outpatient CT scans, demonstrating high sensitivity at a 20% vertebral height loss threshold. The study highlights AI's potential to improve VCF detection, which radiologists often overlook.
2025-06
GlobeNewswire
Nanox.AI Bone Solutions, Advanced AI-Powered Software for Spine Assessment, Recommended by NICE for Early Value Assessment in UK National Health Service hospitals
Nanox.AI's bone solutions, including HealthOST, have been recommended by NICE for early value assessment in UK National Health Service hospitals. These AI tools analyze existing CT scans to opportunistically detect vertebral fragility fractures, aiming to improve early detection and intervention for osteoporosis.
2025-11
ResearchGate
Artificial Intelligence vs Human opportunistic Detection of Vertebral Fractures in Routine CT Scans: results of a pilot study
A pilot study evaluated the diagnostic performance of Nanox.AI's HealthOST AI platform for opportunistic vertebral fracture detection in chest and abdominal CT scans, finding significantly higher sensitivity compared to human readers. The study suggests AI integration could uncover many undiagnosed osteoporosis patients.
2026-01

Videos

Product demos, reviews, and walkthroughs for HealthOST.

View all on YouTube

Frequently Asked Questions

HealthOST is designed with robust API capabilities to ensure seamless integration with most major EHR platforms, allowing for direct data exchange and access within your existing clinical workflow. This minimizes disruption and ensures patient data remains centralized and accessible.
HealthOST employs advanced encryption, strict access controls, and regular security audits to safeguard Protected Health Information (PHI) in full accordance with HIPAA regulations. We also provide comprehensive Business Associate Agreements (BAAs) to ensure data governance and accountability.
HealthOST's AI is a decision-support tool, and its recommendations are based on patterns in historical data, which may contain biases. Physicians must always exercise their independent clinical judgment, considering the AI's output as one data point among others, and never as a definitive diagnosis or treatment plan.
HealthOST offers a flexible, tiered subscription model based on user count and feature requirements, designed to accommodate practices of all sizes. We provide detailed ROI analyses and can help you evaluate its potential to enhance efficiency and patient outcomes, justifying the investment.
HealthOST stands out due to its specialized algorithms tailored for complex diagnostic pathways and personalized treatment recommendations, its intuitive user interface, and its commitment to continuous, physician-driven development. We prioritize actionable insights that directly impact patient care.
Yes, HealthOST has been subjected to extensive internal and external clinical validation studies, demonstrating high sensitivity and specificity for specific conditions. We transparently publish our validation results and continuously monitor performance to ensure ongoing accuracy and reliability.

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Suggest an Edit → | Last Verified: 2026-04-18 | First Added: 2026-04-18
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