LiverMultiScan v5

by Perspectum  · Based in United Kingdom → — A new way to see precision health.
Gastroenterology Radiology
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Regulatory Status Disclosed

Overview

LiverMultiScan v5 by Perspectum is an advanced, non-invasive magnetic resonance diagnostic device software application designed for comprehensive liver evaluation. It utilizes multiparametric MRI to quantify key biomarkers of liver health, including liver fat (Proton Density Fat Fraction – PDFF), iron (Liver Iron Concentration – LIC), and fibroinflammatory activity (corrected T1 – cT1). The software processes DICOM 3.0 compliant MR image datasets from compatible MR systems to generate, display, and review 2D medical image data and pixel maps. LiverMultiScan v5 includes machine-learning based automatic processing for artifact detection and liver segmentation, generating a summary report for clinician interpretation. It aims to provide a complete picture of liver health, aiding in the diagnosis, assessment of disease severity, and monitoring of chronic liver diseases, potentially serving as a non-invasive alternative to liver biopsy.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • Quantitative measurement of liver fat (PDFF).
  • Quantitative measurement of liver iron concentration (LIC).
  • Quantitative measurement of fibroinflammatory activity (cT1).
  • Non-invasive, MRI-based assessment.
  • Standardized, reproducible, and repeatable metrics across MRI scanner platforms.
  • Machine-learning for automatic artifact detection and liver segmentation.
  • Generates easy-to-understand patient-centric reports.
  • Prognostic value for liver and cardiovascular outcomes.
  • Cost-effective compared to alternative methods like biopsy.
  • Widespread insurance coverage in the US.

Use Cases

  • Diagnosis and monitoring of chronic liver disease.
  • Assessment of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Steatohepatitis (MASH).
  • Evaluating liver health in patients with diabetes and cancer.
  • Guiding treatment decisions and monitoring treatment response.
  • Risk stratification for liver and cardiovascular outcomes.
  • Alternative to liver biopsy for liver tissue characterization.

What Physicians Need to Know

GI Pathology Analysis (Liver-specific)
LiverMultiScan v5 is a magnetic resonance diagnostic device software that provides non-invasive evaluation of liver tissue characteristics. It quantifies key metrics such as Proton Density Fat Fraction (PDFF) for liver fat, T2* for iron, Liver Iron Concentration (LIC), and iron-corrected T1 (cT1) for liver disease activity. The software utilizes machine learning for automated artifact detection and liver segmentation to assist in quantification.
MRI System Compatibility
LiverMultiScan v5 is designed to utilize DICOM 3.0 compliant magnetic resonance image datasets. It is approved for use on Siemens, GE, and Philips MRI machines at both 1.5 and 3 Tesla, making use of existing manufacturer software with configuration to establish suitable LiverMultiScan sequences.
Physician Tip

LiverMultiScan v5 is an aid to diagnosis and should be interpreted by trained healthcare professionals, including radiologists, gastroenterologists, and hepatologists. It provides quantitative metrics (PDFF, cT1, T2*, LIC) for a comprehensive, non-invasive assessment of liver health, which can assist in the diagnosis and monitoring of liver disease. The report should not be used as the sole basis for diagnosis.

The system leverages existing DICOM 3.0 compliant image exchange platforms for automated data transfer, with native support for services like Ambra and Powershare. It requires no specific software or hardware installation on the MRI scanner itself, only configuration of existing manufacturer software. Data storage and processing can be performed in the originating region with secure hosting and ISO 27001 information security certification.

Details

Category Gastroenterology AI, Radiology & Imaging AI
Pricing Contact vendor for pricing.
DeploymentCloud-based service, integrates with existing DICOM 3.0 compliant MRI hardware (Siemens, GE, Philips at 1.5T and 3T).
Compliance
BAA AvailableUnknown AI-estimated
HIPAA CompliantUnknown AI-estimated
FDA Status Yes AI-estimated

LiverMultiScan v5 (LMSv5) received 510(k) clearance (K213960) from the U.S. FDA on September 6, 2022, as a Class II magnetic resonance diagnostic device software application for non-invasive liver evaluation.
Integrations
EHR Not specified
Specialties Gastroenterology, Radiology

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Press & Coverage

accessdata.fda.gov
LiverMultiScan v5 (LMSv5) FDA 510(k) K213960
LiverMultiScan v5 (LMSv5) received FDA 510(k) clearance on September 6, 2022, as a magnetic resonance diagnostic device software application for non-invasive liver evaluation. It is intended to assist trained operators with the evaluation of information from MR images to quantify liver health metrics.
2022-09
Ovid (Journal of Magnetic Resonance Imaging)
Stateu2010ofu2010theu2010Art Quantification of Liver Iron With MRIu2014Vendor Implementation and Available Tools
This peer-reviewed article discusses the state-of-the-art in quantifying liver iron with MRI, mentioning LiverMultiScan v5 (LMSv5) as a commercially available tool for R2*-based LIC estimation. It highlights the importance of non-invasive methods for liver iron concentration assessment.
unknown
Thieme E-Books & E-Journals
This Is What Metabolic Dysfunctionu2013Associated Steatotic Liver Disease Looks Like: Potential of a Multiparametric MRI Protocol
This review article explores the potential of multiparametric MRI protocols, including references to LiverMultiScan v5.0, for assessing Metabolic Dysfunctionu2013Associated Steatotic Liver Disease (MASLD) as an alternative to liver biopsy. It emphasizes the need for reliable non-invasive methods for MASLD assessment.
2026-06
Preprints.org
Hepatic Fat Quantification Using Beta Distribution and a Probabilistic Neural Network
This preprint, dated March 26, 2026, references Perspectum's LiverMultiScan v5.1 Guide to Interpreting Liver Tissue Characterization for Physicians (2024) in its discussion of hepatic fat quantification using neural networks. The study retrospectively obtained data using the Perspectum LiverMultiScan workflow.
2026-03
Constat
LiverMultiScan v5 (LMSv5) (K213960) u2014 FDA 510(k) evidence
This entry provides a detailed overview of the FDA 510(k) clearance for LiverMultiScan v5 (LMSv5) by Perspectum, cleared on September 6, 2022. It highlights the device's machine-learning functionality for automatic artifact detection and liver segmentation, and its methods for quantifying PDFF and LIC.
2026-07
X-ray Interpreter
LiverMultiScan | FDA Radiology AI Device
This source lists LiverMultiScan v5 (LMSv5) as an FDA-cleared AI radiology device from 2022. It is part of a broader listing of AI-powered medical devices.
2020-10
Perspectum
Perspectum - Physician Ai Tools
Perspectum highlights LiverMultiScan v5 as an AI-powered, non-invasive tool that provides quantitative reports for physicians globally. This indicates its role in aiding clinical decision-making.
2026-04
MDPI (Diagnostics)
Hepatic Fat Quantification Using Beta Distribution and a Probabilistic Neural Network in a Prepubertal Male Cohort
This peer-reviewed article from May 2026 references the 'LiverMultiScan v5.1 Guide to Interpreting Liver Tissue Characterization for Physicians' (2024) in its methodology for hepatic fat quantification. It details a study using the Perspectum LiverMultiScan workflow on a cohort of prepubertal males.
2026-05

Videos

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Frequently Asked Questions

LiverMultiScan v5 employs AI-enhanced multiparametric magnetic resonance imaging (MRI) to non-invasively quantify key liver health metrics such as fat, iron content, and disease activity. The software processes MR data to generate quantitative reports and parametric maps, with human operators reviewing automated analyses to ensure quality.
LiverMultiScan v5 is a Class II Magnetic Resonance Diagnostic Device, cleared by the FDA under Premarket Notification 510(k) (K213960) for commercial use in the United States. It also holds a CE mark, indicating compliance with European health, safety, and environmental protection standards. Perspectum ensures its products and services comply with major privacy laws, including GDPR, UK GDPR, and HIPAA.
LiverMultiScan v5 offers a non-invasive, pain-free alternative to traditional liver biopsies, which are invasive, carry risks, and are not scalable for long-term monitoring. Studies suggest it is a cost-effective option that can improve diagnosis rates, reduce the need for specialist consultations, and avoid unnecessary biopsies. While biopsy remains a gold standard for certain diagnoses, LiverMultiScan provides quantitative metrics for monitoring disease activity.
LiverMultiScan v5 reports should not be the sole basis for diagnosis and require interpretation by a trained physician in conjunction with other patient data. Its accuracy can be impacted by very high liver fat or iron content; specifically, cT1 accuracy may be reduced above 3.0 mg Fe/g, and LIC can be underestimated when above 3.5 mg Fe/g with PDFF between 10-25%. Additionally, patients with certain metal implants or pacemakers, or those who are pregnant, should inform the technologist.
LiverMultiScan v5 provides three quantitative metrics of liver health: corrected T1 (cT1), Proton Density Fat Fraction (PDFF), and Liver Iron Concentration (LIC). cT1 measures liver disease activity (fibro-inflammation), PDFF quantifies liver fat content (steatosis), and LIC assesses iron concentration, offering a comprehensive view of liver health.
While specific pricing for LiverMultiScan v5 is not publicly detailed, studies indicate it is a cost-effective solution for liver assessment, demonstrating significant cost savings for healthcare systems when used as an alternative to surveillance liver biopsies. It aims to reduce overall healthcare expenditure by streamlining diagnosis and management of liver diseases.

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Suggest an Edit → | Last Verified: 2026-04-18 | First Added: 2026-04-18
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