LiverMultiScan v5
Overview
LiverMultiScan v5 by Perspectum is an advanced, non-invasive magnetic resonance diagnostic device software application designed for comprehensive liver evaluation. It utilizes multiparametric MRI to quantify key biomarkers of liver health, including liver fat (Proton Density Fat Fraction – PDFF), iron (Liver Iron Concentration – LIC), and fibroinflammatory activity (corrected T1 – cT1). The software processes DICOM 3.0 compliant MR image datasets from compatible MR systems to generate, display, and review 2D medical image data and pixel maps. LiverMultiScan v5 includes machine-learning based automatic processing for artifact detection and liver segmentation, generating a summary report for clinician interpretation. It aims to provide a complete picture of liver health, aiding in the diagnosis, assessment of disease severity, and monitoring of chronic liver diseases, potentially serving as a non-invasive alternative to liver biopsy.
Reviewed by Pouyan Golshani, MD — Interventional Radiologist
Key Features
- Quantitative measurement of liver fat (PDFF).
- Quantitative measurement of liver iron concentration (LIC).
- Quantitative measurement of fibroinflammatory activity (cT1).
- Non-invasive, MRI-based assessment.
- Standardized, reproducible, and repeatable metrics across MRI scanner platforms.
- Machine-learning for automatic artifact detection and liver segmentation.
- Generates easy-to-understand patient-centric reports.
- Prognostic value for liver and cardiovascular outcomes.
- Cost-effective compared to alternative methods like biopsy.
- Widespread insurance coverage in the US.
Use Cases
- Diagnosis and monitoring of chronic liver disease.
- Assessment of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Steatohepatitis (MASH).
- Evaluating liver health in patients with diabetes and cancer.
- Guiding treatment decisions and monitoring treatment response.
- Risk stratification for liver and cardiovascular outcomes.
- Alternative to liver biopsy for liver tissue characterization.
What Physicians Need to Know
LiverMultiScan v5 is a non-invasive MRI-based tool that provides quantitative metrics for assessing liver health, including fibro-inflammation (cT1), fat content (PDFF), and iron concentration (LIC). These metrics should be interpreted by a trained clinician in conjunction with other diagnostic tools and the patient's medical history to form a diagnosis. The report is not intended to be the sole basis for diagnosis, treatment decisions, or surgical planning. LiverMultiScan can be used to monitor patients with conditions like autoimmune hepatitis and MASLD/MASH, aiding in risk stratification and treatment response assessment. It is a contrast-free scan and can be combined with other MRI protocols.
LiverMultiScan v5 leverages existing DICOM image exchange platforms for automated data transfer, with native support for systems like Ambra and Powershare. It is designed to work with DICOM 3.0 compliant MRI datasets. The software is approved for use on Siemens, GE, and Philips MRI machines (1.5T and 3T) and uses existing manufacturer software, requiring only configuration. The service is hosted across regional data centers, ensuring data security with ISO 27001 certification.
Details
| Category | Gastroenterology AI, Radiology & Imaging AI |
| Pricing | Unknown |
| Compliance | |
| BAA Available | Unknown |
| HIPAA Compliant | Unknown |
| FDA Status | Unknown |
| Integrations | |
| EHR | Not specified |
| Specialties | Gastroenterology, Radiology |
What the Web Says
LiverMultiScan v5 is a non-invasive diagnostic software application that utilizes MRI data to quantify liver fat, iron content, and fibroinflammation, aiding physicians in the diagnosis and management of liver diseases like NASH and AIH. It is designed to be an additional supporting tool for diagnosis, not a replacement for comprehensive clinical evaluation. The software has shown promise in improving patient understanding of their condition and offering a cost-effective alternative to more invasive procedures like liver biopsy.
Overall: PositiveStrengths
- Non-invasive, reducing risks and discomfort associated with liver biopsies.
- Provides quantitative metrics for liver fat (PDFF), iron content (LIC), and fibroinflammation (cT1) simultaneously.
- Aids in clinical decision-making and patient management plans.
- Can improve patient understanding of their liver disease.
- Demonstrated cost-effectiveness compared to traditional methods like liver biopsy.
- Outperforms some other non-invasive techniques for identifying high-risk NASH patients.
Limitations
- Not intended to replace established procedures for assessing liver health; interpretation by a trained physician is crucial.
- Metrics should not be used as the sole basis for diagnostic decisions.
- Very high liver iron concentration or fat content can reduce accuracy.
- Patients with metal implants, pacemakers, or who are pregnant may not be able to undergo the MRI.
- Potential for sampling bias in ROI selection, especially with heterogeneous fat distribution.
- Not intended for morphological, anatomical, structural, or radiological assessment of images, or for assessing incidental findings.
Based on reviews from: perspectum.com, nih.gov, auntminnie.com, parikhradiology.com, fda.gov, thieme-connect.com, ed.ac.uk, kcl.ac.uk, preprints.org
Last updated: 2026-10-31
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