LiverSmart
Overview
LiverSmart by Resonance Health is an AI-powered software solution designed for comprehensive liver multi-metric measurements. It integrates the capabilities of two existing FDA-cleared devices: FerriSmart®, which quantifies liver iron concentration (LIC), and HepaFatSmart® (which replaced HepaFat-AI®), for automated multi-metric assessment of liver fat. The tool processes MRI datasets to generate a single, consolidated report providing crucial data such as volumetric liver fat fraction (VLFF), proton density fat fraction (PDFF), steatosis grade, and liver fat distribution maps, alongside liver iron concentration. LiverSmart is non-invasive, requires no additional equipment or contrast agents, and its results are unaffected by inflammation, fibrosis, or cirrhosis, providing accurate, reliable, and reproducible data within seconds of data upload.
Reviewed by Pouyan Golshani, MD — Interventional Radiologist
Key Features
- AI-powered solution for liver multi-metric measurements
- Combines FerriSmart (liver iron concentration) and HepaFatSmart (liver fat assessment) into one report
- Non-invasive, MRI-based analysis
- Requires no additional equipment or contrast agents
- Results unaffected by inflammation, fibrosis, and cirrhosis
- Rapid results generation (within seconds of data upload for individual components)
- Accurate, reliable, and reproducible longitudinally
- Provides volumetric liver fat fraction (VLFF), proton density fat fraction (PDFF), and steatosis grade
- Provides liver iron concentration (LIC)
- Secure DICOM file transmission via FAST portal
Use Cases
- Diagnosis and management of patients with iron overload conditions (e.g., hemochromatosis, thalassemia, sickle cell disease)
- Assessment and monitoring of fatty liver diseases (e.g., NAFLD, NASH)
- Monitoring liver iron burden in transfusion-dependent patients
- Supporting clinical trials for new drugs and therapies for liver diseases
- Comprehensive assessment of overall liver health
- Enhancing clinical decision-making and tailoring patient care
What Physicians Need to Know
Consider LiverSmart for non-invasive, comprehensive assessment of liver iron and fat in patients, particularly those with suspected iron overload, fatty liver disease, or conditions requiring longitudinal monitoring of liver health. Leverage the rapid, AI-powered results to inform timely diagnostic and treatment decisions, potentially reducing the need for more invasive procedures like liver biopsy for iron and fat quantification. Integrate LiverSmart reports into patient management plans for a standardized and reliable overview of key liver metrics.
LiverSmart integrates with standard MRI systems for image acquisition. DICOM files are securely transferred via Resonance Health's FAST portal for AI-powered analysis. The processed results and comprehensive reports are then securely transmitted back to the physician through the same portal.
Details
| Category | Gastroenterology AI, Radiology & Imaging AI |
| Pricing | Not publicly disclosed. |
| Deployment | Cloud-based via secure FAST portal for data transmission and analysis, with options for onsite platforms through channel partners. |
| Compliance | |
| BAA Available | Unknown AI-estimated |
| HIPAA Compliant | Unknown AI-estimated |
| FDA Status |
1 AI-estimated LiverSmart (K213776) received FDA clearance on December 29, 2021. It utilizes two existing FDA-cleared devices, HepaFat-AI (K201039, now replaced by HepaFatSmart) and FerriSmart (K182218), combining their respective results into a singular consolidated multi-parametric report for liver iron concentration and fat assessment. |
| Integrations | |
| EHR | Not specified |
| Specialties | Gastroenterology, Radiology |
What the Web Says
LiverSmart, offered by Resonance Health, provides MRI-based solutions for assessing liver iron concentration and fat. It is described as a non-invasive and painless method for doctors to enhance decision-making and tailor patient care. Additionally, there is a dietary supplement also named LiverSmart by Naturenetics, which is a milk thistle-based product designed to support liver function. Reviews for the supplement are generally positive, with users reporting improvements in energy, sleep, and digestion.
Overall: MixedStrengths
- Non-invasive and painless MRI-based assessment for liver iron and fat (Resonance Health's LiverSmart).
- Automated AI-powered analysis for quick results (Resonance Health's LiverSmart).
- Supports healthy liver function and promotes normal digestion (Naturenetics' LiverSmart supplement).
- Contains standardized European milk thistle extract and five other liver-supporting ingredients (Naturenetics' LiverSmart supplement).
- Independently tested for safety and active ingredients (Naturenetics' LiverSmart supplement).
- Vegan, gluten-free, non-GMO, and cruelty-free (Naturenetics' LiverSmart supplement).
Limitations
- Limited independent reviews available specifically for Resonance Health's LiverSmart imaging solution.
- The LiverSmart supplement is more expensive than some other milk thistle products.
- Pregnant women, individuals with severe liver conditions, or those on specific medications should consult a physician before using the LiverSmart supplement.
- Individuals with known allergies to ingredients like artichoke should avoid the LiverSmart supplement.
Based on reviews from: Naturenetics, Reddit, Resonance Health, eBay, Capterra, Ubuy
Last updated: 2026-07-19
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