MedWiseRx
by AnewHealth
· Based in United States →
— Transforming healthcare through comprehensive pharmacy management, helping people with the most complex needs live healthier, wherever they call home.
Contact for pricing
Regulatory Status Disclosed
Overview
MedWiseRx, powered by AnewHealth’s proprietary MedWise technology (originally from Tabula Rasa HealthCare), is an advanced clinical decision support tool designed for proactive medication risk management. It assesses multi-drug interactions, predicts adverse drug events (ADEs), and optimizes medication regimens by incorporating pharmacogenomics, pharmacokinetics, and pharmacodynamics. The technology provides advanced data and clinical insights to help providers and payers identify medication opportunities at the population level and facilitate patient-level interventions. It offers clinical insight at the point of prescribing and delivers focused medication alerts to reduce alert fatigue. MedWise is a unique software platform that identifies simultaneous, accumulative, multi-drug interactions to help ensure medication safety, efficacy, and adherence. It calculates a MedWise Risk Score™ to prioritize at-risk patients and inform interventions, which has been shown to improve outcomes and decrease costs.
Reviewed by Pouyan Golshani, MD — Interventional Radiologist
Key Features
- Assess multi-drug interactions
- Predict adverse drug events (ADEs)
- Optimize medication regimens
- Incorporate pharmacogenomics
- Incorporate pharmacokinetics
- Incorporate pharmacodynamics
- Advanced data and clinical insights
- Proactive identification of medication risks at population level
- Facilitate patient-level interventions
- Clinical insight at the point of prescribing
- Medication alerts with focused insights
Use Cases
- Improving clinical outcomes for large populations
- Managing complex care needs for polychronic patients
- Reducing unplanned healthcare utilization
- Lowering total cost of care
- Enhancing medication safety and efficacy
- Supporting providers and payers in addressing complex medical needs
What Physicians Need to Know
Evidence Base
MedWiseRx is powered by 'MedWise Science,' which assesses simultaneous, accumulative, multi-drug interactions, incorporating pharmacogenomics, pharmacokinetics, and pharmacodynamics. It moves beyond outdated one-to-one drug interaction systems to identify potential adverse drug events (ADEs) and is supported by peer-reviewed, published studies.
Clinical Validation Studies
Multiple studies have validated that medication interventions informed by MedWiseu00ae clinical decision support tools improve health outcomes and lower healthcare costs when used by specially certified pharmacists. A three-part clinical study demonstrated strong associations between a high MedWise Risk Scoreu2122 and poor health outcomes, and that interventions using MedWise reduced medication-related risk, hospitalizations, emergency room visits, and premature death. Previous peer-reviewed studies correlated a lower MedWise Risk Scoreu2122 with fewer ADEs, emergency department visits, hospitalizations, and lower medical costs. MedWise was also used to simulate and predict risks of drug interactions for COVID-19 treatments without patient exposure. One study indicated that hospitalized patients discharged with a MedWise Risk Score greater than 20 were 1.9 times more likely to be re-admitted within 30 days.
Alert Fatigue Management
MedWise improves workflow by highlighting only scores requiring attention, which helps to eliminate alert fatigue by providing focused insights.
Drug Interaction Checking
MedWiseu00ae is a unique software platform that identifies simultaneous, accumulative, multi-drug interactions. It employs a science-backed approach, incorporating pharmacogenomics, pharmacokinetics, and pharmacodynamics to generate a MedWise Risk Scoreu2122.
Guideline Update Frequency
Although a specific update frequency is not explicitly stated, MedWiseRx maintains academic affiliations and partnerships with top pharmacy colleges in the U.S., suggesting a commitment to staying current with advancements in pharmacy science.
Clinical Workflow Integration
MedWise is interoperable with athenahealth and integrates with PioneerRx Pharmacy Software, allowing pharmacists to access the software directly within patient profiles. MedWise decision support tools are also available within the PrescribeWellness software. The system is designed to improve workflow by highlighting only actionable risks.
Decision Audit Trail
Risks identified by MedWise are actionable and documented to improve outcomes and medical cost savings, implying the existence of a decision audit trail for interventions.
Physician Tip
Leverage the MedWise Risk Scoreu2122 to proactively identify patients at higher risk for adverse drug events and multi-drug interactions, especially those on complex medication regimens. Utilize the focused alerts to prioritize interventions and optimize medication therapy, reducing the likelihood of hospitalizations and emergency room visits. Consider consulting with MedWise Advisor pharmacists for complex cases to enhance medication safety and patient outcomes.
MedWiseRx is designed for interoperability, notably integrating with athenahealth and PioneerRx Pharmacy Software, and its decision support tools are available through PrescribeWellness. These integrations aim to embed medication safety insights directly into existing clinical and pharmacy workflows.
Details
| Category | Clinical Decision Support & Reference, Pharmacology & Dosing AI |
| Pricing | Contact for pricing |
| Deployment | Cloud-based |
| Compliance | |
| BAA Available | Yes AI-estimated |
| HIPAA Compliant | Yes AI-estimated |
| FDA Status |
No AI-estimated MedWiseRx is a clinical decision support tool and typically does not require FDA clearance in the same manner as drugs or medical devices. |
| Integrations | |
| EHR | Not specified |
| Specialties | Geriatrics, Hospital Medicine, Internal Medicine |
What the Web Says
MedWiseRx, an industry leader in Medication Therapy Management (MTM), offers comprehensive and flexible programs that include continuous analysis of patient medications to identify potential drug therapy problems. Their services aim to improve patient engagement and outcomes through multichannel outreach and specialized pharmacy experts. The MedWiseRx educational program has also been shown to effectively increase older adults' understanding of Comprehensive Medication Reviews (CMRs) and their benefits.
Overall: MixedStrengths
- Comprehensive and flexible Medication Therapy Management programs.
- Utilizes software solutions for continuous analysis of patient medications to identify drug therapy problems.
- Clinical contact centers provide solutions for pharmacies to focus on patient care and offer customized MTM programs.
- MedWise Safety Review proactively identifies potential adverse drug events (ADEs), enhancing patient care and potentially increasing pharmacy revenue while reducing costs for payers.
- Educational programs effectively increase patient understanding of Comprehensive Medication Reviews (CMRs) and their benefits.
- Offers flexible hours and remote work options for employees.
Limitations
- Some employee reviews mention low pay and limited hours for certain positions.
- Concerns about micromanagement and difficulty reaching management have been raised by employees.
- Some employees report a lack of benefits.
- One review mentions a corporate focus on business and money over healthcare.
- Some patients may be untrusting of medication reviews, requiring effort to build trust.
- A pharmacist intern review mentioned no face-to-face patient interaction.
Based on reviews from: Handshake, AnewHealth, PubMed, Indeed.com, Maryland Insurance Administration
Last updated: 2026-08-04
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Press & Coverage
MedWise HealthCare
TRHC's Sinfonu00edaRx [now MedWiseRxu2122] to Provide Enhanced Clinical Opportunities to Community Pharmacies through Innovative Partnership with Drake University
Tabula Rasa HealthCare (TRHC), through its subsidiary Sinfonu00edaRx (now MedWiseRx), partnered with Drake University's College of Pharmacy & Health Sciences to offer enhanced clinical and telehealth services to community pharmacies. This collaboration aims to expand medication safety initiatives and provide additional revenue opportunities for pharmacies.
2019-10
MedWise HealthCare
TRHC [formerly Sinfonu00edaRx] Publishes Comprehensive 2019 Medication Therapy Management Program Performance Report
Tabula Rasa HealthCare (TRHC), through its subsidiary Sinfonu00edaRx (now MedWiseRx), released its 2019 Medication Therapy Management Program Performance Report. The report highlights the company's efforts in advancing medication safety and patient engagement through its comprehensive MTM services.
2019-03
Drug Topics
5 Tech-Driven Patient Engagement Tools for COVID-19 Vaccination Efforts
This article highlights how Tabula Rasa HealthCare (TRHC) and its MedWiseRx clinical call centers supported COVID-19 vaccination efforts. MedWiseRx provided telepharmacy services, including vaccine appointment scheduling and addressing patient questions, staffed by over 800 pharmacists and pharmacy personnel.
2021-04
ComputerTalk
Our annual survey dives into the chain technology priorities
MedWiseRx clinical contact centers, staffed by over 800 pharmacists and technicians, provided telephonic patient engagement services to alleviate administrative burdens on pharmacies during the COVID-19 vaccine rollout. These services included direct patient outreach, appointment setting, and data entry.
2021-07
PubMed Central (PMC)
Mitigating the Risk of Adverse Effects Related to Augmentation Therapy for Resistant Major Depressive Disorder: A Case Report
This case report, co-authored by researchers from Tabula Rasa HealthCare, MedWiseRx, and the University of Arizona, discusses mitigating adverse drug events in older adults with resistant major depressive disorder through medication therapy management and clinical decision support systems.
2022-03
MDPI (Medicina)
Mitigating Benzodiazepine Dependence and the Risk of Drug-Induced QTc Prolongation in the Treatment of Gastroparesis: A Case Report
This case report, with authors affiliated with MedWiseRx, details a pharmacist's intervention to manage benzodiazepine dependence and reduce the risk of drug-induced QTc prolongation in a geriatric patient with gastroparesis. The intervention involved tapering benzodiazepines and introducing mirtazapine.
2022-03
Commonwealth of Pennsylvania
DISCIPLINARY ACTIONS - February 2022
MedWiseRx was levied a civil penalty of $1,500 by the Pennsylvania Board of Pharmacy in February 2022 for failing to inform the board of a change in pharmacist in charge within 30 days, following disciplinary action by another state.
2022-02
State of Hawaii, Department of Commerce and Consumer Affairs
BOARD OF PHARMACY Minutes of the October 20, 2022, Meeting
The Hawaii Board of Pharmacy meeting minutes from October 2022 mention MedWiseRx in the context of settlement agreements prior to filing of petitions for disciplinary action.
2022-10
Videos
Product demos, reviews, and walkthroughs for MedWiseRx.
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Frequently Asked Questions
MedWiseRx, powered by MedWiseu00ae Science, integrates with Electronic Health Records (EHRs) like athenahealth to provide clinicians with access to proprietary technology for identifying potential adverse drug events (ADEs). It calculates a MedWise Risk Scoreu2122 at the point of prescribing and highlights only scores requiring attention, aiming to optimize medication regimens and improve workflow.
MedWiseRx utilizes MedWiseu00ae Science to identify simultaneous, accumulative, multi-drug interactions, which helps in ensuring medication safety, efficacy, and adherence. It offers tools like the MedWise Risk Scoreu2122 and Medication Risk Mitigation Matrixu2122 to proactively identify patients at higher risk for ADEs.
MedWiseRx operates through a nationwide network of HIPAA-compliant clinical contact centers. These centers are staffed by specialized pharmacy experts who provide high-quality care and patient engagement while adhering to privacy regulations.
While MedWiseRx aims to improve outcomes and reduce costs, its primary delivery mechanism involves clinical contact centers staffed by pharmacists, meaning direct physician interaction with the software for daily decision-making might be indirect. The system is designed to highlight only scores requiring attention, which helps mitigate potential alert fatigue, but integration with diverse EHR systems could present implementation considerations.
Specific pricing for MedWiseRx is not publicly disclosed, as it is primarily marketed to payers, pharmacies, and provider organizations, particularly those in value-based care arrangements. The platform aims to drive significant cost savings for healthcare providers by reducing total medical expenses and preventing ADEs.
MedWiseRx distinguishes itself by focusing on simultaneous, accumulative, multi-drug interaction analysis, moving beyond single-pair drug interaction checks to provide a comprehensive risk score. It also offers a network of clinical pharmacists for consultation and Medication Therapy Management (MTM) services, which may not be as integrated in other standalone drug-interaction software.
Studies have validated that medication interventions informed by MedWiseu00ae clinical decision support tools, when used by specially certified pharmacists, improve health outcomes and lower healthcare costs. Research indicates that a lower MedWise Risk Scoreu2122 correlates with fewer ADEs, emergency department visits, hospitalizations, and reduced medical costs.
Physicians can request consultations with AnewHealth's board-certified clinical pharmacists, who utilize MedWise to help optimize medication regimens. The system provides actionable risks and documented information to support providers in making informed decisions and improving patient outcomes.
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| Last Verified: 2026-05-06 | First Added: 2026-05-06
Investors who backed MedWiseRx
Funded through the company that built this tool.
