MOZI TPS

by Manteia Technologies Co., Ltd.  · Based in China → — The New Treatment Planning System
Oncology

Contact for pricing
Regulatory Status Disclosed

Overview

MOZI TPS (MOZI Treatment Planning System) is a next-generation AI-powered software solution designed for radiation oncology. It combines precision, speed, and adaptability for radiotherapy treatment planning. The system features a Monte Carlo Dose Engine for high-precision dosing, GPU-powered computation for fast processing, and vendor independence, supporting multiple accelerator types. MOZI TPS offers seamless automation, including AI-driven automated contouring and planning, and revolutionary on-line adaptive planning for real-time adaptation to patient anatomical changes. It supports various treatment techniques such as 3D-CRT, IMRT, VMAT, SBRT, and CBCT/MRI-guided on-line adaptation. Its core functions encompass image processing, structure delineation, plan design, optimization, and evaluation for patients with malignant or benign diseases requiring external beam irradiation with photon beams.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • Monte Carlo Dose Engine
  • GPU-powered Computation
  • Vendor Independence (supports multiple accelerator types)
  • Seamless Automation (automated contouring and planning)
  • Revolutionary On-line Adaptive Planning (real-time adaptation)
  • Multi-Scenario Support (3DCRT, IMRT, VMAT, SBRT, On-line Adaptive)
  • Deep Learning based Auto-Planning
  • Image Processing
  • Structure Delineation
  • Plan Design, Optimization, and Evaluation

Use Cases

  • Radiotherapy treatment planning for malignant diseases
  • Radiotherapy treatment planning for benign diseases
  • External beam irradiation with photon beams
  • On-line Adaptive Radiation Therapy (ART) workflow
  • Automated contouring of anatomical structures
  • Dose calculation and optimization

What Physicians Need to Know

Key Capabilities
MOZI TPS is a next-generation treatment planning system for radiation therapy, featuring a Monte Carlo dose engine, GPU-powered computation, and AI-driven planning optimization. It includes built-in deep learning auto-contouring and supports full workflow automation from dose prediction to final plan generation. The system is designed for precision, speed, and adaptability, offering capabilities for 3D-CRT, IMRT, VMAT, SBRT, and online adaptive radiotherapy.
Clinical Utility
MOZI TPS is used to plan radiotherapy treatments for patients with malignant or benign diseases, specifically for external beam irradiation with photon beams. It aims to streamline workflows with automated contouring and planning, enabling real-time adaptive planning and patient-specific goals. The system facilitates online adaptive radiotherapy (oART) by allowing session-by-session adaptation based on anatomical changes, recalculating optimal plans within minutes on existing linear accelerators.
Integration Options
MOZI TPS is a vendor-independent and fully interoperable system, designed to integrate seamlessly into existing workflows. It offers TPS integration, Cloud API, and Linac integration.
Compliance Status
MOZI TPS is approved by the U.S. FDA as a Class II medical device under regulation 21 CFR 892.5050. Its auto-contouring feature has been validated on 187 patients per FDA K223724.
Pricing Model
Unknown
User Experience
The system is designed to optimize user experience and improve physicists' efficiency through features like automated tool detection and image analysis algorithms. It offers an intuitive dashboard with customizable reports.
Support Quality
Unknown
Implementation Complexity
MOZI TPS can be deployed either cloud-based or on-premises. It is designed to integrate into existing workflows, suggesting a focus on seamless adoption.
Evidence Base
The auto-contouring feature has been validated on 187 patients per FDA K223724. Auto-planning models are validated on standard protocols. Clinical data presented at the 2025 Italian Physics Society Annual Meeting showed complex ART cases completed in approximately 20 minutes.
Physician Tip

MOZI TPS offers significant advantages for radiation oncologists seeking to implement or enhance adaptive radiotherapy. Its AI-driven auto-contouring and auto-planning features can substantially reduce planning time, allowing for more efficient workflows. The ability to perform online adaptive radiotherapy (oART) using existing linear accelerators, without requiring new hardware, is a key benefit for institutions looking to upgrade their capabilities cost-effectively. Physicians should leverage the system's ability to adapt treatment plans session-by-session based on daily anatomical changes to personalize treatments and potentially improve patient outcomes, especially in cases requiring high precision or hypofractionated protocols.

MOZI TPS is designed as a vendor-independent and fully interoperable system, facilitating integration into diverse existing radiotherapy environments. It supports standard TPS integration, offers a Cloud API for broader connectivity, and includes direct Linac integration. This flexibility allows it to seamlessly fit into various clinical setups without being tied to specific hardware vendors.

Details

Category Oncology AI, Surgical AI
Pricing Contact for pricing
DeploymentStandalone software
Compliance
BAA AvailableUnknown
HIPAA CompliantUnknown
FDA Status Cleared AI-estimated
Integrations
EHR Not specified
Specialties Oncology

What the Web Says

MOZI TPS by Manteia is a next-generation treatment planning system for radiation therapy, utilizing AI and deep learning to enhance precision, speed, and adaptability in cancer treatment. It aims to streamline workflows through features like automated contouring and planning, and supports various treatment techniques. The system has received regulatory approvals, including FDA clearance, and is designed to be vendor-independent.

Overall: Mixed

Strengths

  • Combines precision, speed, and adaptability in treatment planning.
  • Utilizes AI and deep learning for automated contouring and planning, enhancing efficiency.
  • Supports multiple auto-planning methods for full workflow automation from dose prediction to final plan generation.
  • Features a Monte Carlo dose engine for high-precision dosing in complex cases.
  • Offers GPU-powered computation for lightning-fast processing.
  • Vendor-independent and interoperable, integrating into existing workflows and supporting various accelerator types.

Limitations

  • Relies on accurate input data and requires skilled operation by medical professionals.
  • System compatibility with specific imaging devices can be a limitation.
  • Adapting AI and machine learning algorithms to complex clinical scenarios presents inherent challenges.
  • No peer-reviewed publications evaluating the marketed MOZI TPS were identified as of September 2026, impacting evidence rigor.
  • Dose-prediction model details are vendor-provided and not publicly published, requiring local validation before clinical use.
  • The Smart Optimization Engine's technical evaluation covers only conventionally fractionated IMRT and VMAT plans, with stricter review advised for other plan types.

Based on reviews from: amegroups.cn, nih.gov, healthaidb.com, manteiamedical.com, oxfordscientific.com.au, medicalnewsobserver.com, dlinrt.eu, healthairegister.com, fda.gov, parikhradiology.com

Last updated: 2026-10-30

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Press & Coverage

manteiamedical.com
Italian Media Hails "Epochal Turning Point": MOZI TPS Brings Adaptive Radiotherapy 4.0 to Leading Hospital
Responsible Research Hospital in Italy has adopted Manteia MOZI TPS, an AI-driven treatment planning platform, to launch Online Adaptive Radiotherapy (oART), marking their entry into the Radiotherapy 4.0 era. This advancement is driven by software rather than new hardware, enabling adaptive radiotherapy on existing linear accelerators.
2026-03
researchgate.net
Fully automated intensity-modulated radiotherapy plans for rectal cancer based on deep learning predictions of three-dimensional dose distributions
This study utilized Mozi TPS (version 3.3, Manteia, Xiamen, China) to develop a fully automated IMRT plan design method for rectal cancer, significantly improving efficiency and plan quality. The system integrates optimization templates with clinical constraints to generate high-quality, standardized treatment plans automatically.
2026-06
medicalnewsobserver.com
MOZI Treatment Planning System (MOZI TPS)
MOZI TPS, developed by Manteia Technologies Co., Ltd., is a comprehensive software for radiotherapy planning, integrating image processing, structure delineation, plan design, optimization, and evaluation. It has received U.S. FDA approval as a Class II medical device for external beam irradiation with photon beams.
2024-04
nih.gov
Artificial intelligence in lung cancer: a narrative review of current applications and future directions
This review mentions Manteia MOZI TPS as a tool used in radiotherapy treatment planning, highlighting the role of AI algorithms in cancer care, including lung cancer management. It discusses the transformative impact of AI and future directions for clinical application.
2025-07
fda.gov
FDA 510(k) Premarket Notification for MOZI TPS
The FDA 510(k) premarket notification details MOZI TPS as a standalone software for planning radiotherapy treatments for malignant or benign diseases, with core functions including image processing, structure delineation, plan design, optimization, and evaluation. The document also specifies its intended use for external beam irradiation with photon beams.
2023-07
nih.gov
AI-enabled medical devices in liver cancer care: a systematic review of the FDA database
Manteia Technologies Co., Ltd's MOZI TPS is listed among various AI-enabled medical devices offering segmentation capabilities predominantly designed for radiation therapy planning in liver cancer care. The article reviews the landscape of AI tools in liver cancer, primarily for diagnosis and therapy planning.
2024-04

Videos

Product demos, reviews, and walkthroughs for MOZI TPS.

View all on YouTube

Frequently Asked Questions

MOZI TPS leverages AI for various functions in oncology treatment planning, including deep learning-driven plan optimization, automated contouring (auto-contouring), and dose prediction. It uses AI to automate workflows from dose prediction to final plan generation, enhancing efficiency and consistency.
MOZI TPS is a Class II medical device, approved by the U.S. FDA under regulation 21 CFR 892.5050. It also holds CE certification, indicating compliance with European Union medical device regulations.
While MOZI TPS offers significant advantages, its limitations include a dependence on accurate input data and the need for skilled operation by medical professionals. It also relies on system compatibility with specific imaging devices and faces inherent challenges in adapting AI algorithms to complex clinical scenarios.
Yes, other AI-driven oncology treatment planning tools exist, such as IBM Watson for Oncology and Tempus, which focus on personalized treatment plans and genomic sequencing respectively. EvidenceMD is another AI tool that acts as a reasoning layer over guidelines for chemotherapy regimen selection and sequencing.
MOZI TPS is designed to optimize a wide range of treatment techniques, including 3D-CRT, IMRT, VMAT, and SBRT. It also supports on-line adaptive radiotherapy, allowing for real-time adjustments based on anatomical changes.
MOZI TPS enables a seamless end-to-end on-line adaptive RT workflow by combining image processing, auto-contouring, re-planning, QA, and treatment delivery within minutes. This allows for dynamic adjustment of radiation therapy in real-time, tailoring treatment to changes in tumor position and surrounding healthy tissues.

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Suggest an Edit → | Report an issue | Last Verified: 2026-04-18 | First Added: 2026-04-18
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