MRCP+

by Perspectum  · Based in United Kingdom → — A new way to see precision health
Gastroenterology Radiology

Not specified
Regulatory Status Disclosed

Overview

MRCP+ is an advanced biliary visualization software developed by Perspectum Diagnostics. It utilizes quantitative magnetic resonance imaging (MRI) and artificial intelligence (AI) algorithms to process magnetic resonance cholangiopancreatography (MRCP) images. The tool provides improved visualization of intra-hepatic ducts and enables the measurement of bile duct widths, biliary tree volume, and gallbladder volume. This enhanced data supports physicians in the visualization, evaluation, monitoring, and reporting of hepatobiliary structures, proving particularly relevant for serial evaluation in patients with conditions such as Primary Sclerosing Cholangitis (PSC). MRCP+ is a non-invasive, contrast-free solution, with typical scans taking less than 15 minutes and providing same-day results. It is delivered as a cloud-based service, eliminating the need for additional MRI infrastructure or scan time, and can process data from all 1.5T and 3T GE, Siemens, and Philips MR scanners that support 3-D MRCP sequences.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • Enhanced visualization of the biliary tree and pancreatic duct
  • Quantitative assessment of bile duct widths, biliary tree volume, and gallbladder volume
  • AI algorithms for MRCP image processing
  • Supports diagnostic decisions with accurate and precise metrics, including characterization of strictures and dilatations
  • Enables immediate longitudinal assessment using historic MRCP data
  • Cloud-based service, needing no additional MRI infrastructure or scan time
  • Processes data from 1.5T and 3T GE, Siemens, and Philips MR scanners
  • Non-invasive, no contrast, typical scan takes less than 15 minutes with same-day results
  • AMA designated CPT codes with reimbursement (0723T and +0724T)

Use Cases

  • Diagnosis of pancreatobiliary disease
  • Monitoring progression of pancreatobiliary disease, especially Primary Sclerosing Cholangitis (PSC)
  • Evaluation and reporting of hepatobiliary structures
  • Supporting therapeutic trials in PSC
  • Early detection and management of symptoms and complications of PSC

What Physicians Need to Know

GI Pathology Analysis
MRCP+ uses AI algorithms to provide enhanced visualization and quantitative assessment of the biliary tree and pancreatic duct from MRCP images. It generates 3D models to visualize diameter variations along bile duct segments and can perform regional volumetric analysis of the biliary tree, pancreatic duct, and gallbladder. This aids in the evaluation, monitoring, and reporting of hepatobiliary structures. The software helps in identifying and quantifying abnormalities such as strictures and dilatations, which is particularly relevant for diseases like Primary Sclerosing Cholangitis (PSC).
IBD Assessment Tools
While MRCP+ is primarily focused on biliary diseases, it can be used in conjunction with other Perspectum tools like LiverMultiScan for a comprehensive assessment of liver health in conditions that may overlap with IBD, such as autoimmune liver diseases. The tool provides objective and quantitative metrics that can assist in monitoring disease progression and treatment response in conditions like PSC, which can be associated with ulcerative colitis or Crohn's disease.
Quality Metrics Tracking
MRCP+ aims to improve the consistency and reliability of MRCP assessments. It has been shown to increase radiologists' confidence and reduce inter-reader variability in detecting high-grade strictures. The quantitative metrics provided by MRCP+ help standardize the evaluation of biliary tree abnormalities, which can lead to more consistent patient management.
Endoscopy System Compatibility
MRCP+ processes data from 1.5T and 3T GE, Siemens, and Philips MR scanners that support 3D MRCP sequences. It enhances existing MRCP data without the need for contrast agents.
Physician Tip

MRCP+ offers a non-invasive, quantitative approach to assessing biliary health, which can be particularly useful for diagnosing and monitoring conditions like Primary Sclerosing Cholangitis (PSC). The AI-enhanced 3D visualization and quantitative metrics can improve diagnostic confidence and reduce variability in interpretation compared to conventional MRCP. Consider using MRCP+ for serial evaluation in PSC patients and for assessing bile duct strictures and dilatations. It can also be combined with other imaging biomarkers for a more comprehensive understanding of liver and biliary diseases.

MRCP+ is designed to process data from standard 1.5T and 3T MR scanners from GE, Siemens, and Philips that support 3D MRCP sequences. It can be integrated into existing clinical workflows by utilizing newly acquired or historical non-contrast MRCP images. Perspectum also offers a platform for global imaging services for clinical trials, suggesting potential for integration within research settings.

Details

Category Gastroenterology AI, Radiology & Imaging AI
Pricing Not specified
DeploymentSoftware as a Service (SaaS) / Cloud-based
TrainingUnknown
Compliance
BAA Available No AI-estimated
HIPAA Compliant Yes AI-estimated
FDA Status Cleared AI-estimated
SOC 2 No AI-estimated
GDPR Yes AI-estimated
Integrations
EHR Not specified
Specialties Gastroenterology, Radiology

Support & Reliability

Training ProvidedUnknown

What the Web Says

MRCP+ by Perspectum is a non-invasive imaging tool designed to enhance the visualization and quantitative assessment of the biliary tree and pancreatic duct. It aims to provide more accurate diagnoses, staging, and monitoring of pancreatobiliary diseases, improving upon the subjectivity of traditional MRCP. The technology has shown promise in differentiating various autoimmune liver diseases and in risk stratification for conditions like Primary Sclerosing Cholangitis (PSC).

Overall: Positive

Strengths

  • Non-invasive and quantitative assessment of the biliary tree and pancreatic duct.
  • Reduces subjectivity and improves inter-reader variability compared to conventional MRCP.
  • Provides objective metrics for diagnosis, staging, and monitoring of pancreatobiliary diseases.
  • Differentiates between autoimmune liver diseases like AIH, PBC, and PSC.
  • Potential for quicker, more cost-effective diagnosis and obstruction detection in suspected acute biliary or ductal gallstone presentations.
  • Can be combined with LiverMultiScan for comprehensive liver health assessment.

Limitations

  • No specific cons were identified in the provided search results.
  • Relies on the availability of MRI technology.

Based on reviews from: perspectum.com, lazard.com, nih.gov, postersessiononline.eu, easl.eu, researchgate.net, smarterhealthai.com, plos.org

Last updated: 2026-10-31

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Press & Coverage

perspectum.com
Quantitative MRCP Imaging: Accuracy, repeatability, reproducibility, and cohort-derived normative ranges.
This study found that quantitative MRCP (MRCP+) is an accurate, repeatable, and reproducible method that reduces subjectivity, quantifies duct diameters, and detects strictures and dilatations with high sensitivity and specificity, improving upon the current 'gold standard' for noninvasive biliary tree imaging.
2020
perspectum.com
Evaluation of quantitative MRCP (MRCP+) for risk stratification of primary sclerosing cholangitis: comparison with morphological MRCP, MR elastography, and biochemical risk scores.
This research indicates that MRCP+ quantitative duct metrics correlate with biochemical risk scores and MR elastography in Primary Sclerosing Cholangitis (PSC), offering comparable performance to ANALI morphological scores and improving noninvasive risk assessment when combined with other imaging techniques.
2021
perspectum.com
Validation of quantitative magnetic resonance cholangiopancreatography in prediction of transplant-free survival in primary sclerosing cholangitis.
This publication highlights the clinical utility of MRCP+ in predicting transplant-free survival in PSC patients, with the total number of strictures and proportion of 3-5mm ducts showing strong performance in forecasting PSC-related transplant with stable accuracy over a decade.
2025
perspectum.com
Quantitative MRCP as Part of Primary Sclerosing Cholangitis Standard of Care in the National Health Service in England: A Feasibility Assessment Among Hepatologists.
This study explored the clinical utility of MRCP+ and a proposed pathway for its integration into PSC management, revealing strong interest and trust from hepatologists for diagnosis and monitoring, with pricing unlikely to hinder adoption.
2025
fda.report
MRCP+ v2 510k Summary
Perspectum Ltd. received 510(k) clearance from the FDA for its MRCP+ v2 software, indicated as a software-based image processing system for noninvasive, quantitative assessment of biliary system structures.
2024-03
perspectum.com
New Diagnostic Tool for Biliary Disease Being Assessed for NHS
Perspectum initiated a study to establish the clinical utility of MRCP+, a new quantitative imaging tool for biliary disease, funded by Innovate UK and in partnership with the University of Birmingham and University Hospitals Birmingham, and Oxford Academic Health Science Network.
2019-09
perspectum.com
New Quantitative Biliary Imaging Technology Could Transform PSC Clinical Practice
Perspectum Diagnostics launched MRCP+, a groundbreaking quantitative biliary imaging tool, at the International Liver Congress, with new data from PSC patient studies presented by international biliary experts.
2019-04
prnewswire.com
Data released at The Liver Meeting ® 2018 Shows MRCP+ is a Promising Non-Invasive Technology for Quantitative Evaluation of Hepatobiliary Diseases
Perspectum Diagnostics presented data at The Liver Meeting® 2018 highlighting MRCP+ as a promising non-invasive technology for the quantitative evaluation of hepatobiliary diseases, demonstrating its utility in discriminating biliary disease.
2018-11

Videos

Product demos, reviews, and walkthroughs for MRCP+.

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Frequently Asked Questions

MRCP+ utilizes AI-enabled software to enhance conventional MRCP images, providing quantitative measurements and a 3D model of the biliary tree. This allows for objective assessment of ductal anatomy, aiding in the diagnosis, staging, and monitoring of pancreatobiliary diseases like Primary Sclerosing Cholangitis (PSC) and differentiating between benign and malignant biliary obstructions.
While MRCP+ offers significant advancements, it's important to note that it is a post-processing tool that relies on the quality of the initial MRCP scan. Although it improves inter-reader agreement, some variability in expertise across centers can still exist. Additionally, while it provides detailed quantitative data, clinical correlation remains essential for comprehensive patient management.
Traditional MRCP remains a primary non-invasive alternative, though it is limited by subjective assessments and unstandardized acquisition protocols. Endoscopic Retrograde Cholangiopancreatography (ERCP) is another option, considered the traditional gold standard for some evaluations, but it is invasive and carries risks such as pancreatitis or cholangitis.
Perspectum, the developer of MRCP+, emphasizes compliance and trust, with their products being FDA-cleared and CE-marked. The software processes de-identified, non-contrast MRCP scans, adhering to standards like HIPAA for data privacy.
Specific pricing for MRCP+ is not publicly specified by Perspectum. However, Perspectum does work with imaging centers to pre-negotiate scanner time costs for clinical trials. For related Perspectum technologies like LiverMultiScan, there have been updates to Medicare Administrative Contractor (MAC) fee schedules for reimbursement under CPT Code 0648T, and Perspectum offers a Coverage Support Program to assist with prior authorization and appeals.
MRCP+ is designed to process data from existing MRCP scans, making it compatible with current clinical workflows. It can process data from all 1.5T and 3T GE, Siemens, and Philips MR scanners that support 3D MRCP sequences. The software enhances conventional MRCP data without needing contrast agents, providing standardized quantitative metrics for the pancreatobiliary system.

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Suggest an Edit → | Report an issue | Last Verified: 2026-04-18 | First Added: 2026-04-18
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