Myocardial Strain
Overview
Circle Cardiovascular Imaging’s flagship platform, cvi42, is a comprehensive cardiovascular imaging post-processing software designed to enhance the analysis of Cardiovascular Magnetic Resonance (CMR) and Cardiac Computed Tomography (CCT) images. The Myocardial Strain feature within cvi42 leverages AI-based analysis to quantify myocardial deformation, including longitudinal, circumferential, and radial strain. This advanced capability aids in the assessment of regional and global myocardial function, enabling the detection of subtle alterations in cardiac mechanics that may precede changes in ejection fraction. The platform provides best-in-class image reading and reporting tools for both quantitative and qualitative assessment, supporting clinical and research use with full DICOM and PACS connectivity.
Reviewed by Pouyan Golshani, MD — Interventional Radiologist
Key Features
- AI-based myocardial deformation analysis
- Quantification of longitudinal, circumferential, and radial strain
- Supports Cardiovascular Magnetic Resonance (CMR) imaging
- Supports Cardiac Computed Tomography (CCT) imaging (CT Strain for research use only)
- Semi-automated endocardial and epicardial contour delineation
- Automated tracking of myocardial features throughout the cardiac cycle
- Assessment of global and regional myocardial function
- DICOM and PACS connectivity for seamless workflow integration
- Provides strain rate, displacement, velocity, torsion, and torsion rate metrics
- Comprehensive reporting tools
Use Cases
- Early detection of subclinical myocardial dysfunction
- Diagnosis and assessment of cardiomyopathies
- Evaluation of heart failure with preserved ejection fraction (HFpEF)
- Risk stratification in patients with coronary artery disease (CAD)
- Patient selection for Cardiac Resynchronization Therapy (CRT)
- Monitoring for anticancer therapy cardiotoxicity
What Physicians Need to Know
Leverage AI-driven myocardial strain analysis from both CT and MR to detect subtle functional abnormalities earlier than traditional ejection fraction measurements, particularly in conditions like heart failure. Utilize the comprehensive AI-automated coronary artery assessment tools, including plaque quantification and remodeling index, for precise risk stratification and personalized treatment planning for coronary artery disease. Integrate the AI-based echocardiography solutions for automated, reproducible quantification of left and right ventricular function and strain, streamlining echo workflows. Note that CT Strain and PCAT analysis are currently for research use only. Take advantage of the unified platform for consistent workflows across multiple modalities (MR, CT, Echo) to reduce diagnostic friction and improve efficiency.
cvi42 integrates seamlessly into existing CT workflows and is compatible with all major vendor systems. The platform offers integrations with GE Healthcare (AW workstation or AW Server) and Siemens Healthineers (syngo.via workstation). It supports enterprise-class interoperability with enhancements for hospital IT environments, including PowerScribe One Integration for automated transcription and advanced enterprise security with Single Sign-on (SSO) and Multi-factor Authentication (MFA) via Microsoft Entra. The solutions are vendor-neutral, running on any scanner, and can easily integrate into hospital and enterprise sites with various IT infrastructures.
Details
| Category | Cardiology AI, Radiology & Imaging AI |
| Pricing | Contact for pricing — Not publicly disclosed; contact vendor for details |
| Deployment | On-premise (server-client architecture, integrates with hospital PACS) |
| Compliance | |
| BAA Available | Unknown AI-estimated |
| HIPAA Compliant | Unknown AI-estimated |
| FDA Status |
Yes AI-estimated The cvi42 platform is FDA cleared. Specifically, the K232661 clearance on 12/07/2023 was for cvi42 | Plaque, an AI-enabled solution for coronary plaque analysis. The 'CT Strain' module is noted as being for research use only. CMR-based myocardial strain analysis using cvi42 is widely discussed in clinical research and is part of the FDA-cleared cvi42 platform. |
| Integrations | |
| EHR | Not specified |
| Specialties | Cardiology, Radiology |
What the Web Says
Myocardial Strain, particularly Global Longitudinal Strain (GLS), is a measure of cardiac muscle function that can identify global and regional abnormalities and differentiate types of cardiomyopathy. It is considered an earlier and more sensitive marker of myocardial disease and dysfunction than ejection fraction (LVEF), and it is predictive of cardiovascular adverse events. The technology is used with conventional imaging techniques like echocardiography and cardiac MRI, with Circle CVI offering AI-driven solutions for cardiac CT studies to detect subtle changes over time.
Overall: MixedStrengths
- Earlier detection of myocardial dysfunction than LVEF.
- Provides increased precision in cardiac assessment.
- Identifies global and regional abnormalities in myocardial function.
- Differentiates types of cardiomyopathy.
- Predictive of cardiovascular adverse events.
- Can be used to monitor cardiotoxicity during chemotherapy.
Limitations
- Requires high-quality images and experienced practitioners for accurate measurement.
- The value of detecting sub-clinical changes in predicting clinical outcomes or guiding therapy is still uncertain.
- Myocardial strain measurements are not interchangeable across different software and imaging modalities due to inconsistencies.
- Some strain imaging techniques, like cardiac MRI tagging, are time-consuming and primarily research tools.
- CMR Feature Tracking, while easy to use, has lower reproducibility and resolution than gold standard techniques and is vendor-dependent.
- Considered investigational and not medically necessary for all indications by some policies.
Based on reviews from: PMC, Semantic Scholar, PubMed, My Health Toolkit, Bynder, Reddit, Circle Cardiovascular Imaging (Circle CVI)
Last updated: 2026-07-21
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