Quantib Brain

by Quantib BV  · Based in Netherlands → — AI-powered solutions for quantitative MRI brain analysis.
Neurology Radiology
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Regulatory Status Disclosed

Overview

Quantib Brain, also referred to as Quantib Neurodegenerative (ND), is an artificial intelligence (AI)-based software solution designed to assist radiologists and neurologists in the interpretation and quantitative analysis of brain MRI scans. Originally developed as a spin-off from Erasmus MC, Quantib BV was later acquired by RadNet, Inc. and its solutions are now integrated into DeepHealth’s portfolio. The software automatically segments and quantifies various brain structures, including grey matter (GM), white matter (WM), cerebrospinal fluid (CSF), lobes, and the hippocampus. It also specializes in detecting and quantifying white matter hyperintensities (WMH).

Quantib Brain provides objective assessment of brain changes, crucial for monitoring neurodegenerative diseases such as dementia, Alzheimer’s disease, and multiple sclerosis. It offers longitudinal tracking capabilities to compare changes over time and provides reference centile curves derived from healthy populations to aid in interpreting atrophy development. The software generates comprehensive, detailed reports that can be downloaded or uploaded to a facility’s PACS, and segmentations are available in DICOM secondary capture format. It functions as a post-processing application, historically as a plugin for GE Advantage Workstation platforms, and more recently as an extension for Quantib’s own AI Node platform.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • Automatic segmentation of brain structures (GM, WM, CSF, lobes, hippocampus)
  • Volumetric quantification of brain tissues
  • Detection and quantification of white matter hyperintensities (WMH)
  • Longitudinal tracking of neurodegenerative changes and atrophy
  • Comparison to reference centile curves from healthy populations
  • Detailed, comprehensive reporting
  • DICOM secondary capture format for segmentations
  • Integration with PACS
  • User review and editing of WMH segmentations
  • Support for various neurodegenerative diseases (dementia, MS, Alzheimer's)

Use Cases

  • Assessing and monitoring brain atrophy
  • Detecting and tracking white matter hyperintensities
  • Aiding in the diagnosis and progression monitoring of dementia
  • Supporting the management of multiple sclerosis patients
  • Quantitative reporting for neuroradiologists and neurologists
  • Research in neurodegenerative diseases

What Physicians Need to Know

Brain MRI/CT Analysis
Quantib Brain (now DeepHealth Brain/Quantib ND) is a non-invasive medical imaging processing application for automatic labeling, visualization, and volumetric quantification of segmentable brain structures from MR images. It quantifies grey matter, white matter, cerebrospinal fluid, and white matter hyperintensities (WMH). It supports (contrast) 3DT1 MRI and (contrast) 3D or 2D T2 FLAIR MRI inputs.
Neurodegenerative Disease Screening
A core focus of Quantib Brain (DeepHealth Brain/Quantib ND) is the assessment and monitoring of neurodegenerative changes. It offers automated segmentation of brain structures and WMH, providing insights into atrophy related to Alzheimer's disease, other types of dementia, and for monitoring Multiple Sclerosis (MS) patients. The software provides quantitative measurements and comparisons to reference populations.
Longitudinal Progression Tracking
The tool enables multiple time-point analysis, allowing for the tracking of neurodegeneration and changes in brain atrophy and white matter hyperintensities over time.
Processing Time
The processing time for analysis is stated as greater than 10 minutes.
Physician Tip

Quantib Brain (DeepHealth Brain/Quantib ND) is highly valuable for objective, quantitative assessment and monitoring of neurodegenerative diseases using MRI scans. Physicians can leverage its automated segmentation and volumetric quantification capabilities to gain complementary information for diagnosis and to track disease progression over time, particularly in cases of suspected dementia, Alzheimer's disease, and Multiple Sclerosis. The detailed reports with normative comparisons can aid in clinical decision-making and communication with patients. While it provides automated WMH segmentation, users need to review and potentially edit candidates before validation.

Quantib Brain (Quantib ND) is designed for integration via AI marketplaces or distribution platforms and can be deployed locally on dedicated hardware. It has also been noted as a post-processing plugin for GE Advantage Workstation platforms. DeepHealth aims to provide end-to-end AI-powered solutions and interoperable applications within its Neuro Suite.

Details

Category Neurology AI, Radiology & Imaging AI
Pricing Contact vendor
DeploymentOn-premise (as a post-processing plugin for GE Advantage Workstation/Server; as an extension for Quantib AI Node platform)
Compliance
BAA AvailableUnknown AI-estimated
HIPAA CompliantUnknown AI-estimated
FDA Status 1 AI-estimated

Quantib Brain (including Quantib Neurodegenerative/ND) has received multiple FDA 510(k) clearances. The software is intended for automatic labeling, visualization, and volumetric quantification of segmentable brain structures from MR images, and for the detection and quantification of white matter hyperintensities.
Integrations
EHR Not specified
Specialties Neurology, Radiology

Ratings & Reviews

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Clinical Value
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Press & Coverage

GlobeNewswire
DeepHealth Introduces New AI-Powered Radiology Informatics and Population Screening Solutions at #ECR2025
DeepHealth, a RadNet subsidiary, announced new AI-powered radiology informatics and population screening solutions at ECR2025, integrating technologies from acquired companies like Quantib.
2025-02
Theranostics (International Journal of Medical Sciences)
Theranostics and artificial intelligence: new frontiers in personalized medicine
This review article discusses current and emerging AI applications in theranostics, including Quantib Brain 1.2 for interpretation of MRI brain images, highlighting AI's role in personalized medicine.
2024-03
Seminars in Neurology / PMC
Artificial Intelligence for Neuroimaging and Musculoskeletal Radiology: Overview of Current Commercial Algorithms
This review summarizes FDA-cleared AI products in neuroimaging and musculoskeletal radiology, listing Quantib Brain for quantification of MRI brain images.
2023-04
GlobeNewswire
RadNet Completes the acquisitions of Aidence Holding B.V. and Quantib B.V. to Address Opportunities in Lung and Prostate Cancer Diagnosis and Screening with Artificial Intelligence
RadNet acquired Quantib and Aidence to expand its AI offerings for lung and prostate cancer diagnosis and screening, with Quantib Brain being one of the key solutions.
2022-01
AuntMinnie
RadNet broadens AI focus with acquisitions of Aidence, Quantib
RadNet's acquisition of Quantib and Aidence aims to broaden its AI focus beyond breast imaging to include prostate, brain, and lung AI applications, with Quantib's brain MRI algorithms noted as important for monitoring Alzheimer's patients.
2022-01
RSNA Journals (Radiology)
The Need for Medical Artificial Intelligence That Incorporates Prior Images
This article discusses the importance of AI in medical imaging incorporating prior images, citing Quantib Brain as an example of an FDA-approved device that calculates white matter lesion volume and raw brain volume across several points.
2022-04
AI Blog - ESR
Responsible introduction of AI will help unleash its full potential
This article highlights the FDA clearance of Quantib Brain, which measures changes in the brain related to Alzheimer's disease and MS using segmentation and quantification of brain volumes.
2019-03
DOTmed
FDA gives nod to AI software for brain MR, Quantib ND
Quantib ND received FDA clearance, building on the earlier FDA and CE authorization in August 2016 for Quantib Brain, which automatically extracts biomarkers from brain MR scans.
2019-01

Videos

Product demos, reviews, and walkthroughs for Quantib Brain.

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Frequently Asked Questions

Quantib Brain, now integrated into DeepHealth Brain, functions as a post-processing application that automates the segmentation and volumetric quantification of brain structures from MRI scans. It aids physicians in assessing and monitoring neurodegenerative diseases such as Alzheimer's, other forms of dementia, and Multiple Sclerosis by providing objective measurements of brain atrophy and white matter hyperintensities. This integration streamlines the diagnostic process and supports longitudinal tracking of disease progression.
Quantib Brain and its subsequent iterations, like Quantib Neurodegenerative (ND), have received FDA clearance in the U.S. and CE mark approval in Europe. These clearances confirm its compliance with the necessary medical device safety and effectiveness standards for clinical application in these regions.
While Quantib Brain has been validated in various populations, its performance in specific ethnic groups may require further dedicated assessment. Studies have also indicated that agreement between different AI software packages for normative brain volumetry can be moderate, highlighting potential variability. Additionally, users are expected to review and, if necessary, edit the automatically generated white matter hyperintensity segmentations before final validation.
Several alternative AI solutions for quantitative brain MRI analysis exist in the market. Notable competitors include 3D Slicer, Simpleware, Invivo5, OsiriX MD, Materialise Mimics Care Suite, NeuroQ, BrainSightAI, and Quibim QP-Brainu00ae. These platforms offer comparable functionalities such as automated segmentation and volumetric analysis for various neurological conditions.
Quantib ND, a solution within the Quantib Brain family, is designed for on-premises installation at the provider's facility, where patient scans are processed behind existing firewalls. This architecture helps ensure the protection and privacy of sensitive patient data. While specific details for all Quantib Brain versions were not found, similar AI medical imaging tools emphasize compliance with regulations like GDPR and HIPAA.
Quantib Brain (now DeepHealth Brain) is typically offered under a subscription-based pricing model, which can be structured based on factors like the number of installations or users. It aims to provide cost-effectiveness by automating time-intensive manual measurements, thereby enhancing reporting speed and accuracy. This objective quantitative data can lead to improved diagnostic confidence and more efficient patient management.
Quantib Brain is intended to provide complementary information to a trained medical professional for the evaluation and quantitative reporting of MR brain images. It does not replace physician expertise; rather, it serves as an aid. Users are specifically required to review and, if necessary, edit the automatically generated white matter hyperintensity candidates before validating the segmentations and accessing volumetric information.

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Suggest an Edit → | Last Verified: 2026-04-19 | First Added: 2026-04-19
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