RSI-MRI+

by Cortechs.ai  · Based in United States → — AI-powered precision to optimize patient care. Quantitative imaging insights for neurological and oncological disease.
Oncology Radiology Urology

Overview

RSI-MRI+ is an FDA-cleared artificial intelligence (AI) powered imaging software developed by HealthLytix (which merged with CorTechs Labs in June 2020). It utilizes an advanced diffusion MRI technique called Restriction Spectrum Imaging (RSI), biophysical models, and AI to enhance the visibility of restricted water, a key indicator of cancerous tissue, particularly for prostate cancer. The software is designed to assist radiologists, urologists, and other clinicians in the analysis and interpretation of medical images by providing improved visualization and quantification of restricted water compared to standard diffusion-weighted imaging (DWI). RSI-MRI+ automatically segments the prostate on anatomical T2-weighted images using deep learning algorithms and fuses the derived Restricted Signal Map with anatomical images to support precise anatomical localization. It also generates automated reports, including total prostate volume and segmented prostate images.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • Restricted Signal Map for enhanced visualization of restricted diffusion
  • Color Fusion Series to overlay restricted signal onto anatomical images
  • Automated Prostate Segmentation using deep learning algorithms
  • Automated Segmentation Report with prostate volume and segmented images
  • DICOM export for compatibility with PACS workstations
  • Utilizes Restriction Spectrum Imaging (RSI) technique
  • AI-powered analysis of diffusion-weighted MRI data

Use Cases

  • Early detection of prostate cancer
  • Improved diagnosis of prostate cancer
  • Enhanced visualization and quantification of restricted water in cancerous tissue
  • Assisting radiologists and urologists in analyzing prostate MRI data
  • Post-acquisition image processing for MRI scans

What Physicians Need to Know

Key Capabilities
RSI-MRI+ (now known as OnQ Prostate) is advanced imaging software that utilizes Restriction Spectrum Imaging (RSI), a patented diffusion MRI technique. It improves the visualization and quantification of restricted water compared to standard DWI, enhancing the conspicuity of restricted diffusion. The software automatically segments the prostate on T2-weighted images using a deep learning algorithm, fuses the Restricted Signal Map with anatomical T2-weighted images for localization, and reports total prostate volume along with segmentation results.
Clinical Utility
OnQ Prostate supports improved prostate cancer detection and diagnosis by enhancing the identification of aggressive cancer cells and better characterizing prostate tissue. It aims to reduce unnecessary biopsies by providing more precise diagnostic tools. The technology helps radiologists and urologists collaborate more effectively by providing clear, easy-to-interpret images for decision-making and biopsy targeting.
Integration Options
Cortechs.ai products, including OnQ Prostate, can be integrated into existing workflows. The company has partnered with platforms like CARPL.ai to expand global access to its AI-powered imaging solutions. Data transfer between customer sites and Cortechs.ai online systems occurs over TLS v1.2 connections. Cortechs.ai also offers CTXNode, a DICOM proxy for automated uploading and direct result delivery.
Compliance Status
RSI-MRI+ (OnQ Prostate) is FDA-cleared for sales in the U.S. Cortechs.ai is fully HIPAA compliant, and its processing systems are hosted in highly secure SSAE 16-compliant/SOC 1, 2, and 3-audited, ISO 27001 certified facilities in the US and UK. The US systems are also HITRUST CSF certified. The company has also expanded its CE certification in Europe for its AI imaging platform, including OnQ Prostate.
Pricing Model
Cortechs.ai offers an unlimited subscription model for its quantitative analysis, which allows for processing eligible examinations without a separate charge per individual analysis. This model aims to simplify workflow and reduce the cognitive burden on MRI staff and referring physicians.
User Experience
The software provides clear, easy-to-interpret images to empower collaborative decision-making. It aims to enhance workflow for radiologists and provide confidence in diagnosis.
Support Quality
Cortechs.ai is committed to providing up-to-date infrastructure, privacy, security, and compliance for its cloud processing systems. Users can contact support for more information about cloud security or for the full security statement.
Implementation Complexity
RSI-MRI+ is described as a locally installed solution. Cortechs.ai aims to provide easy solutions to meet unique customer needs.
Evidence Base
OnQ Prostate uses Restriction Spectrum Imaging (RSI), a patented diffusion MRI method identified as an emerging imaging biomarker. Studies have shown that RSI improves the detection, in vivo characterization, and localization of clinically significant prostate cancer, with a stronger correlation to underlying histopathology at the voxel level. Research indicates that RSI-MRI with mpMRI improves PCa detection (85% accuracy) compared to mpMRI alone (79% accuracy). The company provides whitepapers and published research on its solutions.
Physician Tip

OnQ Prostate (formerly RSI-MRI+) leverages Restriction Spectrum Imaging (RSI) to provide enhanced visualization and quantification of prostate tissue, which can aid in distinguishing aggressive cancer cells from benign tissue. This can be particularly useful in cases where standard MRI findings are ambiguous or when a patient has persistently rising PSA with negative prior biopsies. The quantitative maps and automated segmentations can improve confidence in diagnosis, assist in biopsy targeting, and facilitate communication with urologists and other specialists. Remember to integrate the quantitative RSI metrics and regions of interest into your diagnostic impression for comprehensive reporting, especially when billing with relevant CPT codes.

Cortechs.ai solutions are designed for integration into existing clinical workflows, with options for secure data transfer via TLS v1.2 connections and automated DICOM proxy (CTXNode) for efficient image upload and result delivery. Partnerships with enterprise AI ecosystems like CARPL.ai further expand accessibility and integration possibilities within larger healthcare IT infrastructures.

Details

Category Oncology AI
Pricing Unknown
Compliance
BAA AvailableUnknown
HIPAA CompliantUnknown
FDA Status Unknown
Integrations
EHR Not specified
Specialties Oncology, Radiology, Urology

Support & Reliability

What the Web Says

RSI-MRI+ by Cortechs.ai is an FDA-cleared advanced imaging software designed to improve prostate cancer detection and diagnosis. It utilizes Restriction Spectrum Imaging (RSI), a patented diffusion MRI technique, to enhance the visualization and quantification of restricted water compared to standard DWI. Physicians have expressed positive opinions, noting its potential to improve accuracy and reproducibility in prostate MRI, reduce unnecessary biopsies, and aid in earlier detection of clinically significant prostate cancer.

Overall: Positive

Strengths

  • Improves prostate cancer detection and diagnosis.
  • Enhances visualization and quantification of restricted water compared to standard DWI.
  • Potential to improve accuracy and reproducibility of prostate MRI.
  • May lead to fewer unnecessary biopsies and greater diagnostic yield.
  • Aids in earlier detection of clinically significant prostate cancer.
  • Provides increased conspicuity of restricted diffusion.

Limitations

No significant limitations found in public reviews. Consider checking vendor documentation or requesting a demo for a thorough evaluation.

Based on reviews from: Capterra, cortechs.ai, YouTube, G2, physicianaitools.com, appliedradiology.com, Reddit

Last updated: 2026-10-31

Ratings & Reviews

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Clinical Value
Ease of Use
Integration
Support & Docs
Value for Money

Press & Coverage

cortechs.ai
Cortechs.ai Expands European CE Marking for AI-Powered Quantitative Imaging Solutions, Including OnQ™ Prostate
Cortechs.ai announced the expansion of its European CE Marking under EU MDR for its latest imaging products, including OnQ™ Prostate, which utilizes advanced Restriction Spectrum Imaging (RSI)-based quantitative maps. This expansion signifies the company's continued investment in a unified AI-powered quantitative imaging platform across neurology, neuro-oncology, and prostate imaging.
2026-08
cortechs.ai
Enhanced Prostate MRI with OnQ/RSI: Elevating Diagnostic Accuracy for Experts and Novices in Clinical Practice
This article highlights how OnQ™ Prostate, an FDA-cleared software using Restriction Spectrum Imaging (RSI), redefines prostate cancer detection by improving tumor characterization and differentiation between cancerous and non-cancerous tissue. It aims to help both experts and novices achieve more confident diagnoses.
2025-04
cortechs.ai
OnQ™ Prostate Solution Enhances Collaboration and Improves MRI for Cancer Detection
Cortechs.ai launched OnQ™ Prostate in May 2024, an FDA-cleared software solution utilizing Restriction Spectrum Imaging (RSI) to improve prostate cancer detection. RSI's ability to focus on intracellular restricted diffusion provides a clearer picture of prostate tissue, enhancing the identification of aggressive cancer cells and improving diagnostic accuracy.
2025-02
cortechs.ai
Restriction Spectrum Imaging (RSI) improves cancer detection
This article from Cortechs.ai discusses how Restriction Spectrum Imaging (RSI) improves cancer detection by comparing its diagnostic performance with conventional multi-parametric MRI for prostate cancer detection.
2023-11
Business Wire
SimonMed Imaging to Onboard CorTechs Labs’ RSI-MRI+ for Prostate Across North American Imaging Sites
SimonMed Imaging announced an agreement with CorTechs Labs to implement RSI-MRI+ for Prostate across many of its North American imaging sites. This integration aims to support improved detection of clinically significant prostate cancer using an advanced diffusion MRI technique.
2020-08
Applied Radiology
CorTechs Labs Merges with HealthLytix, Expanding AI-Powered Imaging Solutions for Cancer and Neurodegenerative Diseases
CorTechs Labs and HealthLytix merged to leverage AI and genetics for enhanced detection and monitoring of cancer and neurodegenerative diseases. The merger incorporates HealthLytix's RSI-MRI+ for Prostate, which has FDA 510(k) clearance for prostate cancer indications.
2020-07
cortechs.ai
CorTechs Labs and HealthLytix Merge to Deliver Comprehensive AI-Powered Imaging Solutions
Cortechs.ai Inc. merged with HealthLytix, a healthcare technology company, to create a comprehensive suite of radiology artificial intelligence products. The merged entity, retaining the name Cortechs.ai, now includes RSI-MRI+, an FDA-cleared advanced imaging software for prostate cancer detection.
2020-06
Imaging Technology News
AI in Radiology: A Look Back at RSNA 2019
This article reviews AI trends from RSNA 2019, noting HealthLytix (now part of Cortechs.ai) as one of the first vendors to receive FDA clearance for its RSI-MRI+ solution. RSI-MRI+ increases the visibility of imaging biomarkers of cancerous tissue in the prostate.
2020-02

Videos

Product demos, reviews, and walkthroughs for RSI-MRI+.

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Frequently Asked Questions

RSI-MRI+ is FDA-cleared advanced imaging software that utilizes Restriction Spectrum Imaging (RSI), a patented diffusion MRI technique. It leverages an innovative tissue microstructure model to improve the visualization and quantification of restricted water, which is a hallmark feature of cancerous tissue, thereby enhancing prostate cancer detection and diagnosis compared to standard DWI.
RSI-MRI+ is FDA-cleared software, indicating it has met regulatory requirements for its intended use as an automatic post-acquisition image processing software for analyzing diffusion-weighted and anatomical MRI data. It is intended for use by radiologists, urologists, and other clinicians to assist with the analysis and interpretation of medical images in various settings such as hospitals, clinics, and medical offices.
RSI-MRI+ is not intended for use in pediatric populations and is not intended to diagnose, treat, or prevent diseases or conditions. While it significantly improves conspicuity of restricted diffusion compared to standard DWI, conventional diffusion MRI, which relies on apparent diffusion coefficient (ADC), can be affected by confounding factors that may impact sensitivity and specificity to cancer.
Alternatives to RSI-MRI+ for prostate cancer imaging include conventional multiparametric MRI (mpMRI), though studies suggest RSI-MRI can outperform it in detection. More broadly, other AI applications in oncological imaging exist for tasks like tumor characterization, identifying imaging biomarkers, and tailoring treatment plans, and AI tools are being developed for MRI-only radiation therapy planning.
The specific pricing structure for RSI-MRI+ is not publicly available. However, for quantitative MRI post-processing, providers can bill using Category III CPT codes (0648T and 0649T for OnQ Prostate, which uses RSI technology) to pursue reimbursement for these advanced imaging services. Reimbursement for AI-assisted quantitative brain MRI also has Category III CPT codes (0865T and 0866T). Many commercial insurers have added these Category III quantitative imaging codes to their covered services lists.

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Suggest an Edit → | Report an issue | Last Verified: 2026-04-18 | First Added: 2026-04-18
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