THINQ

by CorticoMetrics  · Based in United States → — AI-powered MRI brain volumetric reporting for enhanced neurological assessment.
Neurology Radiology

Not publicly disclosed
Regulatory Status Disclosed

Overview

THINQ is an AI-based software developed by CorticoMetrics, designed for advanced MRI brain volumetric reporting. It received 510(k) clearance from the U.S. Food and Drug Administration (FDA) on September 30, 2020, classifying it as a Class II medical device (Radiological Image Processing System, 21 CFR §892.2050).

The software automatically segments T1-weighted MRI brain images, providing precise volumetric measurements and visualizations of 30 critical brain structures. These measurements are then compared to age and gender-matched reference percentile data, offering quantitative insights for clinical assessment. THINQ generates comprehensive neuromorphometry reports in PDF format, which include color-coded segmentations of the brain and plots illustrating how measurements compare to the reference data. Additionally, brain segmentations are available in DICOM format as encapsulated JPEG images.

THINQ is intended for use by radiologists and neurologists to augment patient assessment for a range of neurological disorders and conditions, aiming to increase examination throughput and improve the overall quality of patient outcomes. It is packaged as a container for deployment and operation within a high-performance computing environment in a clinical workflow.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • Automatic segmentation of T1-weighted MRI brain images
  • Volumetric measurements of 30 critical brain structures
  • Visualization of brain structures with color-coded segmentations
  • Comparison to age and gender-matched reference percentile data
  • Quantitative neuromorphometry reports in PDF format
  • DICOM format output for brain segmentations (encapsulated JPEG images)
  • Aids workflow of radiologists and neurologists
  • Aims to increase examination throughput

Use Cases

  • Augmenting patient assessment for neurological disorders and conditions
  • Automating brain morphometry
  • Providing quantitative information for neurological disorders (e.g., dementia, epilepsy, multiple sclerosis, TBI)
  • Improving clinical decision making in neuroradiology

What Physicians Need to Know

Brain MRI Analysis
THINQ automatically segments T1-weighted MRI brain images, providing volumetric measurements and visualizations of 30 critical brain structures. It compares these measures to age and gender-matched reference percentile data, with reporting including color-coded segmentations and plots. The brain segmentations are also available in DICOM format as encapsulated JPEG images.
Neurodegenerative Disease Screening
THINQ offers quantitative information to augment patient assessment for various neurological disorders and conditions, including dementia, multiple sclerosis, and traumatic brain injury. It aims to improve the accuracy and sensitivity of information available to radiologists and neurologists for detection or diagnosis.
Epilepsy Diagnosis Support (MRI-based)
The software aids in the detection or diagnosis of neurological disorders and conditions such as epilepsy by providing detailed MRI brain volumetric reporting.
Physician Tip

Physicians can leverage THINQ for objective, quantitative MRI brain volumetric reporting, which can enhance examination throughput and improve the overall quality of patient assessment for various neurological conditions. The detailed volumetric data, compared against normative populations, provides valuable insights for diagnosing and monitoring neurodegenerative disorders and other brain-related conditions.

THINQ outputs brain segmentations in DICOM format as encapsulated JPEG images, facilitating integration into Picture Archiving and Communication Systems (PACS) and existing clinical workflows. CorticoMetrics, which commercializes neuroimaging analysis software like FreeSurfer, also has tools for DICOM anonymization and converting FreeSurfer outputs to DICOM, indicating a focus on interoperability with standard neuroimaging data formats.

Details

Category Neurology AI, Radiology & Imaging AI
Pricing Not publicly disclosed
DeploymentPackaged as a container for high-performance computing environment within a clinical workflow.
Compliance
BAA AvailableUnknown AI-estimated
HIPAA CompliantUnknown AI-estimated
FDA Status 1 AI-estimated

THINQ received 510(k) clearance (K192051) from the U.S. FDA on September 30, 2020. It is a Class II medical device (21 CFR §892.2050, Radiological Image Processing System) intended for automatic labeling, visualization, and volumetric quantification of segmentable brain structures from MR images.

Integrations
EHR Not specified
Specialties Neurology, Radiology

Ratings & Reviews

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Clinical Value
Ease of Use
Integration
Support & Docs
Value for Money

Press & Coverage

Neurology
Novel Visualization of the Topographical Model of Multiple Sclerosis Using 3D Rendering of Quantified MRI (P11-6.014)
This article discusses the use of THINQ by Corticometrics, alongside NeuroQuantMS 3.1, to process 3D T1 & T2 FLAIR MRI sequences for visualizing the topographical model of multiple sclerosis. The study assesses the feasibility of depicting localized lesions, parenchymal volumetrics, and 3D surface meshes to convey disease burden in an intuitive format.
2024-04
American Psychological Association
A Practical Approach to Incorporating Quantitative Neuroimaging Findings into Pediatric Neuropsychological Test Interpretation
This publication mentions Corticometrics' THINQ as one of the FDA-cleared products for quantitative neuroimaging analysis in a practical approach to integrating such findings into pediatric neuropsychological test interpretation. It highlights the role of automated image analysis programs in providing fast and reliable quantification of brain structures.
2024-01
Frontiers in Neuroscience
A systematic review of structural neuroimaging markers of psychotherapeutic and pharmacological treatment for obsessive-compulsive disorder
This systematic review notes CorticoMetrics' THINQ as an FDA-approved version of the FreeSurfer neuroimaging analysis software package for clinical use, suggesting its potential to increase the accessibility of structural brain metrics. The article explores structural neuroimaging markers in the context of obsessive-compulsive disorder treatment.
2022-11
Journal of Neurology
Commercial volumetric MRI reporting tools in multiple sclerosis: a systematic review of the evidence
This systematic review identifies THINQ by Corticometrics as one of the commercial quantitative volumetric reporting tools for assessing multiple sclerosis. It notes that these tools received regulatory approval between 2006 and 2020 and provide longitudinal assessment of whole-brain volume and lesions.
2022-11
accessdata.fda.gov
CorticoMetrics LLC September 30, 2020 Mr. Nick Schmansky Co-Founder, CEO 128 Granite Street ROCKPORT MA 01966 Re: K19205
This FDA 510(k) summary details the clearance of THINQu2122 as a software-only medical device for automatic labeling, visualization, and volumetric quantification of segmentable brain structures from MRI data. It outlines the device's intended use, technical specifications, and validation against expert-labeled images and normative data.
2020-09
National Institute on Aging - NIH
CorticoMetrics resubmitted full application - National Institute on Aging - NIH
This resubmitted grant application from CorticoMetrics details the ongoing development of THINQ, their first product, which automatically generates neuromorphometry reports from MRI data. It mentions the intent to file for 510(k) pre-market approval and discusses the product's capability for unbiased longitudinal analysis of surface-based neuromorphometrics.
2019-06
National Institute on Aging - NIH
Corticometrics original full application - National Institute on Aging
This original grant application from CorticoMetrics outlines the development of THINQ, a product designed to automatically generate neuromorphometry reports from MRI data. It highlights the goal of commercializing a longitudinal, neuro-morphometric image processing pipeline to aid in earlier and more accurate detection of changes in brain structures for neurological conditions.
2018-04

Videos

Product demos, reviews, and walkthroughs for THINQ.

View all on YouTube

Frequently Asked Questions

THINQ, specifically CorticoMetrics' product, is an AI-based software designed for improved MRI brain volumetric reporting, aiding radiologists and neurologists in assessing various brain disorders by providing automatic measurements and visualizations. Additionally, platforms like ThincHealth, which share the 'Thinq' naming convention, offer AI for rapid medical report summarization and real-time clinical decision support, integrating seamlessly into existing healthcare infrastructures.
For products like CorticoMetrics' THINQ, FDA 510(k) clearance is a critical compliance aspect, indicating it meets safety and effectiveness standards for medical devices. For any AI handling patient data, adherence to HIPAA is paramount to ensure patient confidentiality and secure data processing, as highlighted by platforms like ThincHealth. Furthermore, global frameworks like the EU AI Act, MDR, and ISO 42001 provide comprehensive guidelines for AI in medical devices, covering risk management, technical documentation, and data governance.
While AI tools like THINQ can enhance efficiency and accuracy, they are not a substitute for human medical judgment and require physician oversight. Potential risks include the possibility of AI models introducing bias, struggling with voice differentiation or context interpretation in ambient scribe functions, and the need for continuous retraining to maintain accuracy as medical data patterns shift. Physicians must critically review AI-generated recommendations and retain ultimate responsibility for clinical decisions.
Alternatives to AI-powered diagnostic support include traditional manual analysis by specialists, while other AI tools offer functionalities like AI medical scribes for documentation (e.g., Abridge, Nuance DAX), AI medical research assistants (e.g., Perplexity, OpenEvidence), and AI for imaging and diagnostics support. General AI chatbots like ChatGPT and specialized platforms like Glass Health also provide decision support and differential diagnosis tools.
The cost of implementing healthcare AI solutions like THINQ can vary significantly based on complexity, data readiness, and integration needs. Small-scale projects might start around $10,000-$50,000, while diagnostic AI systems can range from $50,000 to $300,000. Larger, enterprise-level AI implementations that integrate with existing hospital systems like EMR/EHR can exceed $300,000, with ongoing costs for model retraining and maintenance adding $1,000-$5,000 per month.

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Suggest an Edit → | Last Verified: 2026-04-21 | First Added: 2026-04-21
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