Fifth Eye

Ann Arbor, MI, USA  All United States companies → — Founded 2017
Point-of-Care Diagnostics Specialty-Focused AI
Cardiology Critical Care Emergency Medicine Hospital Medicine
Cardiology AI Triage & ER/ICU AI
Series A
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Products

Analytic for Hemodynamic Instability (AHI)
Fifth Eye Inc.
Cardiology AI
Fifth Eye's AHI System is an FDA-cleared, AI-driven clinical decision support software that continuously monitors adult in-hospital patients for signs of hemodynamic instability, providing early warnings hours ahead of traditional vital signs.

See all 1 product →

About Fifth Eye

Fifth Eye is a healthcare AI company that develops FDA-cleared medical device software designed to predict and monitor hemodynamic instability in hospital patients. Their primary product, the Analytic for Hemodynamic Instability (AHI) System, analyzes continuous electrocardiogram (ECG) signals to provide healthcare professionals with real-time patient status updates and early warnings of clinical deterioration.

The AHI System aims to give clinicians a significant lead time—reportedly over 26 hours on average before a Rapid Response Team (RRT) event and 48 minutes ahead of traditional vital signs—to intervene and potentially prevent adverse events, improve patient outcomes, and reduce hospital costs. The technology was originally developed at the University of Michigan and is designed to be non-invasive, using a single ECG lead to continuously detect, trend, and predict the risk of hemodynamic instability in adult patients throughout the hospital, including in high-acuity environments like the ICU, as well as step-down units and general wards.

Focus Areas

AI-based clinical analytics hemodynamic instability prediction real-time patient monitoring clinical decision support predictive analytics medical device software

Business Intelligence

TechnologyAI-based analysis of continuous electrocardiogram (ECG) signals, supervised machine learning, browser-based user interface

What Physicians Need to Know

Specialization
AI-powered clinical analytics and predictive patient monitoring, specifically focusing on early detection of hemodynamic instability.
Key Differentiator
Fifth Eye's AHI System is an FDA-cleared medical device software that predicts hemodynamic instability using only Lead II ECG signals, providing up to 48 minutes (and in some studies, over 26 hours) of lead time ahead of traditional vital signs.
Technology Stack
The AHI System utilizes machine learning and advanced signal processing analyses of continuous ECG (Lead II) waveforms to extract heart rate variability (HRV) patterns indicative of a patient's hemodynamic status.
Real-time Clinical Decision Support
The system provides continuous surveillance data, real-time patient status updates, and clear 'red' (problem) and 'green' (no problem) outputs, reducing nursing burden and enabling timely interventions.
Origin
Fifth Eye's technology was spun out of the University of Michigan's Integrative Research in Critical Care group and licensed from the university.
Physician Tip

Fifth Eye's AHI System offers a significant advantage by providing an early warning of hemodynamic instability, often hours before changes are evident in traditional vital signs. This extended lead time allows for proactive intervention, potentially preventing adverse events, improving patient outcomes, and optimizing resource allocation. The system's ability to generate insights from a single ECG lead, without manual data input, streamlines workflow and reduces nursing burden. Physicians can use the clear 'red' and 'green' indicators to quickly prioritize patients and make informed decisions, even in high-acuity settings like the ICU or general hospital wards.

Fifth Eye's AHI System is designed to integrate with existing hospital ECG monitoring systems. It is also available to customers using Medical Informatics Corp.'s Sickbay™ Platform and has an agreement with VitalConnect to provide predictive patient analytics through their wearable biosensor technology.

Products by Fifth Eye

1 product in the directory

Analytic for Hemodynamic Instability (AHI)
Fifth Eye Inc.
Cardiology AI
Fifth Eye's AHI System is an FDA-cleared, AI-driven clinical decision support software that continuously monitors adult in-hospital patients for signs of hemodynamic instability, providing early warnings hours ahead of traditional vital signs.

What the Web Says

Fifth Eye is a company that develops an FDA-cleared medical device software, the AHI System, which monitors and predicts hemodynamic instability using Lead II ECG signals. The system aims to provide early detection of hemodynamic changes, reduce nursing burden, improve patient prioritization, and enable timely interventions. The company was founded in 2017 and is headquartered in Ann Arbor, Michigan, with an employee count of 11-50. While there is information available about their product, comprehensive reviews from platforms like G2, Glassdoor, Capterra, or Reddit specifically for "Fifth Eye" (the medical device company) are limited. Most search results for "Fifth Eye" reviews on these platforms pertain to unrelated eye care products or other companies with similar names. Therefore, a detailed analysis of pros and cons based on widespread user reviews is not possible at this time.

Overall: Mixed

Strengths

  • AHI System is FDA-cleared.
  • Monitors and predicts hemodynamic instability.
  • Offers 48-minute lead time ahead of vital signs.
  • Aims to reduce nursing burden.
  • Aims to improve patient prioritization.
  • Aims to enable timely interventions.

Limitations

  • Limited publicly available product reviews from specified platforms.
  • Limited publicly available employer reviews from specified platforms.

Based on reviews from: Elion Health, Indeed.com

Last updated: 2026-10-22

Videos

News, demos, and interviews about Fifth Eye.

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Press & Coverage

Arboretum Ventures
Fifth Eye Announces Andrew Malcolmson as new President & CEO
Fifth Eye announced the appointment of Andrew Malcolmson as its new President and CEO, replacing founder Jen Baird. Malcolmson brings over 20 years of experience in growing medical and dental technology businesses.
2022-11
BioSpace
Fifth Eye Receives FDA Clearance to Market AHI System™
Fifth Eye received FDA clearance to market its second-generation clinical decision support software, the AHI System™, to hospitals.
2022-01
MobiHealthNews
FDA grants De Novo classification to Fifth Eye's continuous hemodynamic status monitoring tool
The FDA granted De Novo classification for Fifth Eye's Analytic for Hemodynamic Instability (AHI) tool, which links with existing electrocardiograms to continuously monitor patients' hemodynamic status. The tool demonstrated 96% sensitivity in identifying hemodynamic instability.
2021-03
Pulse 2.0
University of Michigan Medical Device Software Spinoff Fifth Eye Raises $11.5 Million
Fifth Eye raised $11.5 million in a Series A funding round led by Arboretum Ventures and Cultivation Capital, with participation from MINTS and other investors. The funding was intended for FDA clearance, clinical studies, and commercial launch of the AHI System.
2019-04
HealthManagement.org
Fifth Eye Appoints Eric Pergler as Vice President of Sales
Fifth Eye appointed Eric Pergler as Vice President of Sales to drive sales of the AHI System™, an FDA-cleared medical device software designed to reduce preventable adverse events.
2022-08
Business Wire
AirStrip Acquires Fifth Eye to Advance Predictive Clinical Surveillance
AirStrip announced the acquisition of Fifth Eye, integrating the FDA-cleared AHI System into AirStrip ONE to enhance clinical surveillance and decision-support capabilities.
2025-06
Weil Institute, University of Michigan
Weil Institute spinoff company Fifth Eye, Inc. joins the fight against cancer
Fifth Eye Inc. was accepted into the 2025 CancerX Accelerator Program to explore the AHI System's predictive capabilities in managing cytokine release syndrome (CRS) in cancer patients.
2025-04
PR Newswire
Fifth Eye's AHI System: Detects shock, patient deterioration hours ahead of vital signs
Fifth Eye showcased its AHI System at HLTH 2023, highlighting its ability to detect patient deterioration hours ahead of vital signs using AI to interpret waveform signals.
2023-09

Frequently Asked Questions

Fifth Eye's AI-powered solution focuses on early detection of hemodynamic instability, a critical factor in patient deterioration. By continuously analyzing standard ECG signals, it provides real-time alerts and predictive insights, enabling clinicians to intervene sooner and potentially prevent adverse events like septic shock or cardiac arrest, thereby improving patient outcomes and reducing ICU stays.
Fifth Eye's system is designed for seamless integration with existing hospital monitoring equipment and EHR systems. It typically connects to central monitoring stations or directly to bedside monitors to acquire ECG data, and its output can be displayed on existing clinical dashboards or pushed into the EHR for comprehensive patient record keeping and clinical decision support.
Fifth Eye's AIDE system has received CE Mark certification and FDA 510(k) clearance, indicating its compliance with medical device regulations in Europe and the United States. Clinical efficacy and safety are supported by studies demonstrating its ability to accurately predict hemodynamic instability and improve patient management.
Fifth Eye typically offers a subscription-based pricing model, which may vary depending on the scale of deployment and specific hospital needs. The company provides comprehensive technical support, including installation, ongoing maintenance, and dedicated training programs for clinicians and IT staff to ensure effective utilization of the system.
Fifth Eye differentiates itself by utilizing a novel AI approach that extracts hemodynamic information solely from standard ECG signals, without requiring additional sensors or complex setups. This allows for continuous, non-invasive, and highly sensitive detection of subtle changes indicative of impending instability, often earlier than traditional vital sign monitoring or other early warning scores.
Fifth Eye has established partnerships with leading medical device companies and research institutions to further integrate and validate its technology. The company is privately held and backed by venture capital, demonstrating a commitment to long-term growth and innovation in AI-powered clinical analytics and predictive patient monitoring.

Comparisons

Analytic for Hemodynamic Instability (AHI) vs Sleepiz One+
Analytic for Hemodynamic Instability (AHI) vs EchoNext
Analytic for Hemodynamic Instability (AHI) vs Irregular Rhythm Notification Feature (IRNF)
Analytic for Hemodynamic Instability (AHI) vs Study Watch with Irregular Pulse Monitor

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