Flybridge

VC Boston, United States · Founded 2002

Flybridge is an early-stage venture capital firm that focuses on backing ambitious founders at the pre-seed and seed stages who are building transformative companies for an AI-powered future. They believe that every company will eventually be an AI company and emphasize community-driven strategies in their business models.

About Flybridge

Flybridge is a Boston and New York-based early-stage venture firm with a generalist thesis spanning consumer, enterprise, and selective frontier technology investing, with a track record that includes some healthcare and digital health exposure. The flybridge.com website and the firm’s public profile reflect an established multi-fund platform with brand-name partners (Jeff Bussgang and others) who have written and spoken extensively about venture investing. For healthcare AI founders, Flybridge is a credible generalist option, particularly for businesses with strong product-led growth, B2B SaaS economics, or consumer technology with healthcare applications. Plausible check sizes run 500K to 3M at seed and Series A, with the firm comfortable leading at the earliest stages. Follow-on capacity exists. Founders building healthcare AI with strong software DNA, founder-product fit, and clear category leadership potential should approach. Founders pitching deep biology, regulated medical devices, or healthcare services should look at specialist firms; Flybridge does not advertise that depth. Entry path is warm introduction through the Boston or New York founder networks, especially through Harvard Business School alumni given Bussgang’s faculty role there, or LinkedIn outreach to partners with a sharp pitch. The firm reads inbound and responds, but the signal-to-noise is heavy. Diligence will be sharp on team, market, and product, with a generalist software lens. Expect Flybridge to push hard on category dynamics and founder edge. Bring evidence that you can build a category-defining business, not just a profitable one; the firm invests for outcomes, not lifestyle businesses.

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Healthcare AI tools backed by Flybridge

Tools made by companies in Flybridge's portfolio that we cover in the directory.

Concentriq AP-Dx
Proscia
Clinical Decision Support & Reference
Proscia's Concentriq AP-Dx is an FDA-cleared enterprise digital pathology platform for primary diagnosis, designed to accelerate diagnostics and drug development by providing an intuitive experience for viewing, interpreting, sharing, and managing whole slide images.
Mesh AI
Mesh AI
Practice Management & Scheduling
Mesh AI is a staff scheduler for physician and resident groups with complex schedules: save time and eliminate conflicts and errors with transparent collaborative scheduling. The company boasts over 11,000 happy clinicians, 48,000+ shifts exchanged, 9M+ hours scheduled, and an 80% reduction in scheduling time.

Portfolio companies in our directory

Other portfolio companies

Companies in Flybridge's portfolio not currently in our directory.

  • BitSight · 2011
  • H2Ok Innovations

Team

Chip Hazard
General Partner
LinkedIn
Jeff Bussgang
General Partner
LinkedIn
Jesse Middleton
General Partner
LinkedIn
Dorothy Chang
Venture Partner
LinkedIn
Anna Palmer
Venture Partner
LinkedIn
Matt Guiney
Chief Financial Officer
LinkedIn

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Last updated 2026-05-06. Sourced from this fund's published materials.
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