cvi42 Coronary Plaque
Overview
The cvi42 | Plaque solution by Circle Cardiovascular Imaging is an AI-enabled, on-premise software application designed for comprehensive coronary plaque analysis directly from Cardiac CT Angiography (CCTA) scans. It empowers cardiac imaging teams to quantify atherosclerotic burden, delivering precise measurements of plaque volume, burden, composition (calcified, non-calcified, and low attenuation), and distribution. The tool integrates seamlessly into existing CT workflows, providing automated coronary lumen and wall segmentation for rapid and reproducible plaque quantification. Beyond stenosis assessment, cvi42 | Plaque identifies high-risk features like low-attenuation plaques and remodeling index, offering superior prognostic information. It provides full user control with manual adjustment capabilities for annotations and supports lesion-level occlusion marking for revascularization planning. This FDA-cleared solution enhances diagnostic workflows, improves risk stratification, and informs more personalized patient care.
Reviewed by Pouyan Golshani, MD — Interventional Radiologist
Key Features
- AI-enabled coronary plaque quantification
- Automated coronary lumen and wall segmentation
- Per-lesion and per-vessel plaque analysis
- Quantification of calcified, non-calcified, and low attenuation plaque
- Remodeling index calculation
- Integrated into CT workflow
- On-premise solution
- Full user control with manual adjustments
- Enhanced coronary reporting
- Compatible with all major vendor systems
Use Cases
- Comprehensive coronary plaque analysis
- Risk stratification for coronary artery disease
- Personalized treatment planning
- Diagnostic workflows enhancement
- Evaluation of atherosclerotic burden
- Revascularization planning
What Physicians Need to Know
Leverage the AI-enabled quantification of total, calcified, non-calcified, and low-attenuation plaque from CCTA for precise risk stratification and personalized treatment plans. Utilize the on-premise solution to maintain control over patient data, improve study processing times, and enhance workflow efficiency, avoiding the need for external reading services. Integrate the detailed plaque analysis, including remodeling index and low-attenuation plaque assessment, to identify high-risk plaques beyond traditional stenosis assessment, as this offers superior prognostic information. Capitalize on the new Category I CPT code (75577) for AI-enabled coronary plaque analysis, which facilitates reimbursement and recognizes plaque quantification as standard clinical care. Use the integrated CAD-RADS classification for standardized reporting and improved communication within the care team.
cvi42 | Plaque is designed to integrate seamlessly into existing CT workflows and is compatible with all major vendor systems. It is available as part of the broader cvi42 platform, which also supports cardiac MR. The platform offers simplified integrations with PACS/VNA, EMR, DICOM, HL7, and reporting interfaces. As an on-premise solution, it keeps image data, AI processing, and reporting within the institution's environment, enhancing data control and security.
Details
| Category | Cardiology AI, Radiology & Imaging AI |
| Pricing | Contact vendor for pricing details. — Subscription-based; scales across CT and MR service lines; new CPT codes enable reimbursement. |
| Deployment | On-premise |
| Compliance | |
| BAA Available | Unknown AI-estimated |
| HIPAA Compliant | Unknown AI-estimated |
| FDA Status |
1 AI-estimated Received 510(k) clearance from the U.S. Food and Drug Administration (FDA) on October 27, 2025, for the cvi42 Coronary Plaque Software Application (K251027). It is classified as an Automated Radiological Image Processing Software (Class II - Special Controls, product code QIH). |
| Integrations | |
| EHR | Not specified |
| Specialties | Cardiology, Radiology |
What the Web Says
cvi42 Coronary Plaque is an AI-enabled, on-premise software solution designed for comprehensive coronary plaque analysis from CT angiography (CCTA) scans. It has received FDA 510(k) clearance and is available for clinical use in the United States. Physicians and healthcare IT professionals highlight its ability to provide fast, accurate, and reproducible quantification of total, calcified, and non-calcified plaque, supporting precise risk stratification and personalized treatment plans. The software integrates into existing CT workflows and is compatible with major vendor systems, offering an in-house solution that enhances diagnostic workflows and patient care.
Overall: PositiveStrengths
- Provides fast, accurate, and reproducible quantification of total, calcified, and non-calcified plaque.
- Supports precise risk stratification and personalized treatment plans.
- On-premise solution, allowing clinicians greater control over data, improved study processing times, and enhanced workflow efficiency without sending patient data to external services.
- Integrates seamlessly into existing CT workflows and is compatible with all major vendor systems.
- New Category I CPT code (75577) for AI-enabled coronary plaque analysis, effective January 1, 2026, facilitates national pricing and physician reimbursement, with coverage from Medicare and major commercial payers.
- Automated coronary lumen and wall segmentation, per-lesion and per-vessel analysis, and remodeling index calculation help identify high-risk plaques.
Limitations
- Potential for bundling and denials with new CPT codes, requiring refined billing practices.
- Multiple Procedure Payment Reduction (MPPR) can cut reimbursement for subsequent imaging codes in the same session.
- Productivity adjustments in Physician Fee Schedule (PFS) may erode physician office rates.
- Requires qualified medical professionals experienced in examining cardiovascular CT images for proper use.
- Some Reddit discussions indicate that coronary calcium scores (a related but distinct concept) are not universally embraced or understood, with some physicians questioning their value for certain patient populations.
Based on reviews from: DAIC, HMP Global Learning Network, Circle Cardiovascular Imaging, Capterra, Innolitics, SourceForge, Reddit
Last updated: 2026-07-20
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cvi42 | Plaque overview and demo
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