CVI42
Overview
CVI42 by Circle Cardiovascular Imaging is an advanced, AI-enabled software platform designed for comprehensive cardiovascular and cerebrovascular imaging analysis. It provides clinically validated tools for accurate diagnosis, procedural planning, and post-treatment management across various cardiovascular workflows. The platform integrates advanced MR automation, comprehensive coronary plaque, PCAT, and vascular CT analysis and planning tools, with seamless integration into existing imaging workflows. CVI42 is engineered for workflow optimization, allowing cardiac teams to interpret studies faster with greater reproducibility and accuracy, leading to more consistent, data-driven reporting and increased throughput. It supports the full continuum of cardiovascular care, from diagnosis to long-term disease management, and is trusted by leading healthcare institutions worldwide.
Reviewed by Pouyan Golshani, MD — Interventional Radiologist
Key Features
- AI-automated coronary lumen and wall segmentation
- Comprehensive coronary plaque analysis (calcified, non-calcified, low-attenuation)
- Advanced CMR automation (T1 mapping, 4D flow pre-processing)
- Vascular CT analysis and planning tools
- Automated detection of suspected coronary lesions
- Pericoronary Adipose Tissue (PCAT) analysis (research use only)
- 3D visualization and image fusion
- Automated contouring of regions of interest
- Multi-vendor and multi-modality support (CT, MR)
- Simplified and enhanced reporting
Use Cases
- Diagnosis of cardiovascular diseases
- Endovascular procedure planning
- Post-treatment surveillance and management
- Risk stratification for coronary artery disease
- Evaluation of heart failure and structural heart disease
- Research in cardiovascular imaging
What Physicians Need to Know
Leverage CVI42's AI-driven automation for cardiac CT and MR to significantly reduce post-processing time and enhance reproducibility in quantifying cardiac function, flow, and tissue characteristics. Utilize the cvi42 | Plaque module for comprehensive, on-premise coronary plaque analysis, including detailed characterization of plaque burden and composition, which can aid in precise risk stratification and personalized treatment planning for coronary artery disease. The ability to perform in-house plaque analysis with FDA-cleared AI and a dedicated CPT code can also streamline workflows and support reimbursement. Furthermore, the platform's insights into LV/RV function and EAT volume from CMR can contribute to a more informed assessment of heart failure risk.
CVI42 is designed for seamless integration into existing clinical workflows. It is vendor-independent, compatible with all major CT vendor systems, and offers full DICOM connectivity to PACS for image transfer and saving reports. It also supports HL7 compatibility for integration with reporting systems and EMRs, with specific integration with PowerScribe for automated transcription and improved workflow continuity. The platform can be deployed as a standalone workstation or in a client/server environment, providing flexibility for different hospital and practice settings.
Details
| Category | Cardiology AI, Radiology & Imaging AI |
| Pricing |
Contact for pricing
|
| Deployment | On-premise solution |
| Compliance | |
| BAA Available | Unknown AI-estimated |
| HIPAA Compliant | Unknown AI-estimated |
| FDA Status |
1 AI-estimated CVI42 (K141480) received 510(k) clearance from the U.S. FDA on August 22, 2014, for viewing, post-processing, qualitative, and quantitative evaluation of cardiovascular CT or MR images for diagnostic information. More recently, cvi42 | Plaque (K251027) received 510(k) clearance on October 27, 2025, for AI-enabled, on-premise quantification of atherosclerotic burden. |
| Integrations | |
| EHR | Not specified |
| Specialties | Cardiology, Cardiothoracic Surgery, Radiology |
What the Web Says
CVI42, developed by Circle Cardiovascular Imaging, is a medical imaging software platform designed for the analysis of cardiovascular and neurovascular CT and MRI scans. It utilizes AI and clinical validation to provide automated diagnosis tools, aiming to streamline workflows and enhance diagnostic accuracy for healthcare professionals. The software is used globally in over 1,700 sites, including many top hospitals. Recently, CVI42 | Plaque, an AI-powered, on-premise solution for coronary plaque analysis, received FDA clearance, allowing for in-house evaluation of coronary artery disease.
Overall: PositiveStrengths
- Comprehensive cardiovascular imaging solution for both MR and CT studies.
- AI-powered tools for automated analysis, including plaque quantification and segmentation, leading to high-speed and accurate results.
- Enhances workflow efficiency and reduces diagnostic friction by unifying anatomy, function, and inflammation analysis in a single platform.
- On-premise solution for plaque analysis allows clinicians greater control over data, improved processing times, and potential for maximized reimbursement.
- Strong customer service and a commitment to continuous improvements and innovation.
- Vendor-agnostic and integrates smoothly with existing CT platforms and PACS/reporting systems.
Limitations
- High initial investment and ongoing maintenance costs may be a barrier for smaller clinics.
- Some advanced features like CT Strain and Quantitative Perfusion are for research use only.
- Capterra and SoftwareSuggest show no user reviews, making it difficult to gauge widespread user satisfaction from those platforms.
- ITQlick rates its cost as 4/10, indicating it is less expensive than the average medical imaging tool, but still a significant investment.
- Setting up and navigating the system can feel complex at first, especially for smaller teams.
Based on reviews from: Capterra, ITQlick, DAIC, TechnologyCounter, SourceForge, Circle CVI Global, RAD Magazine, SoftwareSuggest, VA.gov, AuntMinnie, accessdata.fda.gov, G2
Last updated: 2026-07-20
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Press & Coverage
Videos
Product demos, reviews, and walkthroughs for CVI42.
RSNA 2023: cvi42 Integration Demo by Circle Cardiovascular Imaging
Frequently Asked Questions
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