Products

C the Signs
C the Signs Ltd.
Clinical Decision Support & Reference
C the Signs uses artificial intelligence (AI) to identify patients at risk of cancer at the earliest, most curable stage. The company aims to change the course of cancer, fueled by humanity, powered by science, and grounded in the belief that everyone, everywhere, deserves the chance to survive.

See all 1 product →

About C the Signs

C the Signs is an AI-powered clinical platform designed to revolutionize early cancer detection. Founded by NHS doctors, the company’s mission is to make early cancer detection a standard for all patients, not a privilege. The platform integrates seamlessly with electronic health records (EHRs) and utilizes artificial intelligence to analyze a wide array of patient data points, including clinical signs, symptoms, risk factors, lifestyle, family history, medical history, drug history, comorbidities, and past test results. This comprehensive analysis allows the system to identify patients at risk of over 100 cancer types, often before a clinician might suspect it, and recommend the most appropriate diagnostic tests or referrals in under 60 seconds.

By proactively identifying high-risk individuals, C the Signs aims to shift healthcare from a reactive to a predictive model, significantly increasing the chances of survival by detecting cancers at their earliest and most curable stages (Stage 1 or 2). The platform has demonstrated impressive results within the UK’s National Health Service (NHS), identifying breast cancer cases years earlier than standard pathways and improving early-stage ovarian cancer diagnoses. Beyond clinical decision support, C the Signs also offers population risk stratification, automated tracking and safety-netting of patients, and real-time dashboards with cancer performance data, contributing to reduced diagnostic delays, improved patient outcomes, and a more equitable and cost-effective cancer care pathway.

What Physicians Need to Know

Specialization
C the Signs specializes in AI-powered clinical decision support for early cancer detection. Their platform helps healthcare professionals identify patients at risk of cancer earlier, faster, and more accurately.
Key Differentiators
C the Signs differentiates itself through its high sensitivity (99% for identifying patients with cancer), high negative predictive value (99% for safely ruling out risk), and 94% accuracy in predicting tumor origin. It analyzes a wide range of personal and environmental data points beyond basic risk factors like age and gender, including demographic, lifestyle, family history, medical history, drug history, comorbidities, and past test results. The platform also offers both active risk assessment during consultations and passive risk assessment by screening electronic medical records. It's built by doctors for doctors, ensuring real-time clinical support seamlessly integrated into existing workflows.
Technology Stack
The company utilizes a microservice cloud-based architecture for resilience and scalability. Early infrastructure included AWS services like EC2, S3, and Elastic Cloud. The platform is designed for interoperability and integrates with electronic health record (EHR) systems.
Physician Tip

For physicians, C the Signs offers a tool to make faster, more confident decisions while maintaining clinical autonomy. It provides instant, tailored guidance on next steps, from urgent referrals to diagnostic tests, in under 30-60 seconds. The platform helps identify rare, complex, or vague cancer presentations and recommends personalized investigations or referrals based on national and local guidelines, drawing on over 1,000 validated signs, symptoms, and risk factors. It can reduce unnecessary screenings by ruling out low-risk patients, thereby easing the burden on primary care and healthcare resources. The system also includes real-time dashboards for tracking suspected and confirmed cancer patients, automating safety-netting, and providing performance data. This can lead to a significant increase in cancer detection rates, as demonstrated by a 12.3% increase in one study, without requiring additional staff time.

C the Signs is built with interoperability at its core and seamlessly integrates into electronic health record systems. Specifically, it integrates with NHS electronic medical record systems such as EMIS, SystmOne, and Vision, covering over 97% of primary care EHR systems in the UK. It is FHIR/HL7 compliant. The platform works within existing electronic health records, aiming for no extra clicks and no disruption to workflow.

Products by C the Signs

1 product in the directory

C the Signs
C the Signs Ltd.
Clinical Decision Support & Reference
C the Signs uses artificial intelligence (AI) to identify patients at risk of cancer at the earliest, most curable stage. The company aims to change the course of cancer, fueled by humanity, powered by science, and grounded in the belief that everyone, everywhere, deserves the chance to survive.

Reviews & Opinions

No web reviews on file yet for C the Signs. Check back later for aggregated opinions from across the web.

Videos

News, demos, and interviews about C the Signs.

Loading videos...

Videos load interactively. If none appear, search YouTube for C the Signs →

View all on YouTube

Press & Coverage

Various (e.g., Hit Consultant, Business Wire, The BAE HQ)
C the Signs Raises $8M to Expand AI-Powered Cancer Detection to the U.S.
C the Signs secured $8 million in funding led by Khosla Ventures to expand its AI-powered cancer detection platform from the UK to the US. The platform has shown success in the NHS by identifying breast cancer cases earlier and improving ovarian cancer diagnosis.
2025-01
PR Newswire / Press Release Hub
British Technology company, C the Signs, selected by the White House-Backed Accelerator Programme, CancerX, to half Cancer Deaths
C the Signs was selected as the only British company in the inaugural cohort of the White House CancerX Accelerator program, an initiative to halve cancer mortality. The AI platform has detected over 25,000 cancer patients with 98% accuracy.
2024-02
The Guardian
GPs use AI to boost cancer detection rates in England by 8%
An AI tool called 'C the Signs' has increased cancer detection rates in GP practices in England from 58.7% to 66.0%. The system analyzes patient medical records to identify cancer risks and recommend appropriate tests or referrals.
2024-07
C the Signs Newsroom / Mayo Clinic Magazine
Mayo Clinic Magazine highlights C the Signs' impact on early cancer diagnosis
Mayo Clinic Magazine featured C the Signs, highlighting its AI models that detect patterns across tumor types and its 'closed-loop learning' system. Retrospective analysis showed the platform identified cancers up to five years earlier in 26% of patients across five high-mortality cancer types.
2025-07
Journal of Clinical Oncology (ASCO Publications)
Leveraging electronic medical records for early lung cancer diagnosis: An evaluation of the C the Signs AI cancer prediction platform using the Mayo data platform.
A study published in the Journal of Clinical Oncology evaluated C the Signs' AI platform for early lung cancer detection using Mayo Clinic data. The platform achieved a sensitivity of 91.5% and identified 26.6% of cases up to five years earlier than traditional diagnoses.
2025-05
Journal of Clinical Oncology (ASCO Publications)
Shifting the paradigm: Early identification of colorectal cancer with C the Signs clinical decision support.
This study in the Journal of Clinical Oncology assessed C the Signs for early colorectal cancer identification, reporting a sensitivity of 93.8% and identifying 29.4% of patients at risk up to 5 years earlier than primary care physicians.
2025-01
C the Signs Newsroom
AI drives earlier cancer diagnosis and 808 percent ROI
A new study presented at the ASCO Care Quality Symposium 2025 and published in the Journal of Clinical Oncology (JCO Oncology Practice) demonstrated an 808% ROI for the NHS with C the Signs. The platform led to 272 earlier diagnoses and £1.5 million in annual cost savings in Suffolk and North East Essex.
2025-01
Benzinga (via Newsweek)
This AI Tool Could Spot Cancer Years Before Diagnosisu2014 And The FDA Is Taking A Look
C the Signs' AI-powered cancer detection tool is under review by the FDA for De Novo clearance, potentially making it the first approved device of its kind in the U.S. The company aims to launch the tool next year to help clinicians identify cancer risks from existing medical records.
2026-06

Frequently Asked Questions

C the Signs offers an AI Cancer Prediction Platform designed to improve earlier and faster cancer detection. It's a cloud-based software that integrates with electronic medical record systems (EMIS, SystmOne, Vision) to identify patients at risk of cancer in under 30 seconds. The platform provides real-time decision support, automated tracking and safety-netting for patients with suspected or diagnosed cancer, population risk stratification, and a real-time cancer dashboard with performance data. It also facilitates real-time patient communication and triages patients to the correct clinical pathway.
C the Signs is committed to protecting patient privacy and personal data. Their platform is UKCA marked and registered with the Medicines and Healthcare products Regulatory Agency as a class one medical device. They are also working with the FDA to determine the best regulatory pathway for the U.S. market. The company's privacy policy details what data they collect, how it's used, and user rights, emphasizing transparency in data use. They maintain encryption and protection of data, including NHS numbers, and facilitate audit and log tracing of user actions. While the search results mention general data protection regulations like GDPR, specific details on how C the Signs adheres to each aspect of HIPAA or GDPR beyond general privacy commitments are not explicitly provided.
C the Signs' pricing is listed at £0.20 to £0.33 per unit per year, with a free trial available. While a specific breakdown of different tiers or subscription options for various healthcare organizations isn't detailed, the pricing is presented on a per-unit annual basis.
C the Signs offers support for technical issues and user queries via email and a help desk phone number. They are also noted for being very good at providing education and are available to offer training to users. The company emphasizes embedding their platform into everyday clinical workflows and working closely with GP practices and cancer alliances to ensure strong adoption and clinical confidence.
C the Signs has a partnership with the Mayo Clinic, where their AI model was used to analyze patient records for colorectal cancer detection. They have also been selected for the White House-backed CancerX Accelerator program, collaborating with organizations like AstraZeneca, Intel, Dell Technologies, and AWS. Additionally, they have received funding from Khosla Ventures, known for backing AI-driven healthcare technologies.
C the Signs is a venture-backed company that recently secured $8 million in Series B funding from Khosla Ventures, bringing their total fundraising to $15 million. This funding is intended to expand their technology and capabilities, and to facilitate their entry into the U.S. market, where they are building a team and working with the FDA. They aim to expand their AI-powered early cancer detection platform to revolutionize cancer care in the United States.
C the Signs' AI platform has demonstrated high accuracy and effectiveness. It has a reported sensitivity of 99%, a negative predictive value (NPV) of 99%, and a tumor site accuracy of 94%. Studies have shown it can identify patients at risk of cancer earlier than traditional diagnoses, with some cancers flagged up to five years before conventional methods. For example, it identified 20.7% of breast cancer cases up to five years earlier and improved early detection of ovarian cancer by 53.3%. Research with the Mayo Clinic showed a sensitivity of 93.8% for colorectal cancer, comparable to a colonoscopy. The platform has been validated in real-world studies and has helped detect over 70,000 patients with cancer.

Investors

Who's funded C the Signs.

Related Companies

Perimeter Medical Imaging AI is a medical technology company dedicated to transforming cancer surgery through the use of ultra-high-resolution, real-time, advanced imaging tools. The company’s mission is to address significant unmet medical needs in cancer surgery, particularly concerning positive margins and the resulting need for re-excisions. Their proprietary technology, including the S-Series Optical Coherence Tomography […]

Veeva Systems is a global leader in cloud-based software solutions specifically designed for the life sciences industry, including pharmaceutical and biotech companies. The company’s offerings are crucial for managing various aspects of drug development, pharmaceutical manufacturing, and commercial operations. Their platforms help clients navigate complex regulatory requirements, improve operational efficiency, and accelerate the delivery of […]

The University at Buffalo (UB) is a prominent public research university and a flagship institution of the State University of New York (SUNY) system. While UB itself is a broad academic institution, the provided URL (halsted.compbio.buffalo.edu) points to a specific area within UB focused on computational biology. This division is actively engaged in healthcare AI […]

SOPHiA GENETICS is a healthcare AI company that has developed a cloud-native, AI-driven SaaS platform called SOPHiA DDM™. This platform is designed to enable hospitals, clinical laboratories, academic medical centers, and biopharmaceutical companies to analyze and interpret complex genomic, radiomic, and multimodal healthcare data. The company’s mission is to democratize data-driven medicine, providing actionable insights […]

Prenaital is an AI-driven healthcare company focused on revolutionizing maternal care by improving the early detection and management of high-risk pregnancies. Their AI models analyze ultrasound images to identify at-risk pregnancies, including those with abnormal fetal growth and a risk of preterm birth, with significantly higher accuracy than current clinical practices—detecting 25-50% more high-risk cases. […]

PHQ Screeners is a free, open-access resource maintained by Pfizer, providing a comprehensive suite of Patient Health Questionnaire (PHQ) and Generalized Anxiety Disorder (GAD-7) screening instruments. These tools were developed by Drs. Robert L. Spitzer, Janet B.W. Williams, and Kurt Kroenke with an educational grant from Pfizer, and are widely utilized in primary care and […]

AI Tool Finder
AI-powered search. Results may not be comprehensive.