4DMedical (Imbio CAC Software)

Melbourne, Victoria, Australia, and Woodland Hills, California, United States. Imbio's former headquarters was Minneapolis, Minnesota, United States.  All United States companies → — Founded 2012 (4DMedical); 2005 (Imbio)
Imaging AI Specialist Specialty-Focused AI
Publicly Held (4DMedical); Formerly VC-backed (4DMedical); Acquired/Merged (Imbio)
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Products

CAC Software
4DMedical (Imbio CAC Software)
Cardiology AI
Imbio's Coronary Artery Calcification (CAC) software is a set of automated image post-processing algorithms designed to help radiologists and cardiologists determine the location and calculate the amount of calcification within the coronary arteries in patients who have undergone a non-contrast, chest computed tomography (CT).

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About 4DMedical (Imbio CAC Software)

4DMedical, which acquired Imbio, is a medical technology company that develops advanced imaging software for respiratory care, with offices in Australia and the United States. The company’s core offering, XV Technology®, utilizes patented algorithms derived from aerodynamics research to process and enhance X-ray and Computed Tomography (CT) images. This technology measures airflow throughout all regions of the lung, across all phases of breath, providing clinicians with quantitative lung ventilation data in a comprehensive report. This approach allows for the detection of subtle functional losses before irreversible structural damage occurs, potentially enabling earlier and more impactful treatment.

For physicians, 4DMedical’s solutions, including XV LVAS (X-ray Velocimetry Lung Ventilation Analysis Software) and CT LVAS (Computed Tomography Lung Ventilation Analysis Software), offer non-invasive assessments of regional lung motion and airflow. These cloud-based technologies process existing imaging data to generate detailed maps of pulmonary function, with color-coded lung images highlighting functional deficits. The company also offers a Lung Health Imaging Panel, which expands the value of thoracic CTs by providing quantitative outputs relevant to broader cardiopulmonary health, including Coronary Artery Calcification (CAC) quantification, lung density analysis, and tools for lung cancer screening. The acquisition of Imbio further enhances this portfolio by adding market-leading AI solutions for anatomical and tissue analysis from CT scans, creating a comprehensive cardiothoracic imaging solution set.

Focus Areas

Respiratory diagnostics lung function assessment medical imaging software AI-powered image analysis for chronic lung and cardiothoracic diseases quantitative lung ventilation analysis and cardiopulmonary health screening solutions.

Business Intelligence

Technologyproprietary XV Technology, Imbio Technology, mathematical models and algorithms, AI, machine learning, cloud-native, SaaS model

What Physicians Need to Know

Respiratory Diagnostics & Lung Function Assessment
4DMedical (Imbio CAC Software) offers advanced software solutions like XV Lung Ventilation Analysis Software (XV LVAS®) and CT LVAS™ to dynamically quantify regional lung ventilation and identify deficiencies. They also provide Lung Density Analysis (LDAi and LDAf) for quantifying emphysema, COPD, consolidation, and ground glass, and Lung Texture Analysis (LTA) for identifying interstitial lung diseases (ILDs) and fibrotic conditions.
AI-Powered Medical Imaging Software
The company specializes in AI-powered image analysis for chronic lung and cardiothoracic diseases. Their Coronary Artery Calcification (CAC) software utilizes AI to identify and quantify coronary artery calcification from non-contrast chest CT imaging, providing an Agatston Score, arterial age, and detailed lesion breakdown. They also offer AI-driven algorithms for lung cancer screening, automatically detecting nodules.
Cardiopulmonary Health Screening Solutions
4DMedical (Imbio CAC Software) provides comprehensive cardiopulmonary diagnostic suites. Their CAC tool brings actionable cardiovascular risk data into the workup of patients with breathlessness, helping distinguish between cardiac and pulmonary causes of dyspnea. The Lung Health Imaging Panel expands the value of thoracic CT by providing quantitative outputs relevant to emphysema assessment, cardiovascular risk, and UIP identification.
Key Differentiators
A key differentiator is their patented XV Technology®, which enables physicians to understand regional airflow in the lungs and identify respiratory deficiencies earlier and with greater sensitivity. They offer non-invasive, quantitative imaging and analysis of lung function, including dynamic, real-time images of the lungs. Their solutions can extract rich data on lung function from standard X-ray and CT scans, often without the need for additional imaging or contrast. The integration of 4DMedical's functional analysis with Imbio's anatomical and tissue analysis creates a comprehensive cardiothoracic imaging solution.
Technology Stack
Their technology stack includes advanced AI and deep-learning based algorithms for image analysis. They utilize machine learning to analyze non-contrast thoracic CT images. Their software operates on a Software-as-a-Service (SaaS) delivery model, integrating with existing hospital imaging equipment. They also employ sophisticated texture mapping algorithms and segmentation techniques.
Physician Tip

For physicians, 4DMedical (Imbio CAC Software) offers objective, reproducible quantification and 3D visualization for efficient interpretation of medical images. The AI-powered analysis provides rapid, fully-automated results compatible with any non-contrast chest CT, streamlining comprehensive patient evaluation. The detailed reports, including Agatston Score, Arterial Age, and lesion breakdowns, help guide lifestyle and preventative care discussions. The software integrates directly into PACS for immediate review and clinical workflow, and provides a Physician Summary Report. This allows for earlier and more accurate diagnoses, leading to more precise and personalized treatment plans and improved patient outcomes.

4DMedical (Imbio CAC Software) solutions are designed for direct routing to PACS for immediate review and integration into clinical workflow. Imbio's Lung Density Analysis (LDA) has been integrated into Nuance PowerScribe radiology reporting workflows via the Nuance AI Marketplace and PowerShare Network. They have also partnered with Blackford to integrate their Lung Density Analysis and RV/LV Analysis software into the Blackford Platform. The company's SaaS model allows integration into existing hospital infrastructure.

Products by 4DMedical (Imbio CAC Software)

1 product in the directory

CAC Software
4DMedical (Imbio CAC Software)
Cardiology AI
Imbio's Coronary Artery Calcification (CAC) software is a set of automated image post-processing algorithms designed to help radiologists and cardiologists determine the location and calculate the amount of calcification within the coronary arteries in patients who have undergone a non-contrast, chest computed tomography (CT).

What the Web Says

4DMedical (Imbio CAC Software) receives generally positive feedback for its product, particularly for its AI-powered cardiac computed tomography (CT) analysis capabilities. Users appreciate its efficiency and accuracy in identifying coronary artery calcification (CAC) and other cardiac risk factors. As an employer, reviews are less prevalent but suggest a generally positive work environment, though specific details are limited.

Overall: Positive

Strengths

  • Efficient and accurate AI-powered analysis for cardiac CT scans.
  • Helps in early detection and risk stratification of cardiovascular disease.
  • Integrates well with existing PACS systems.
  • User-friendly interface for clinicians.
  • Reduces manual interpretation time for radiologists.
  • Provides quantitative data for better patient management.
  • Positive impact on patient care through early diagnosis.

Limitations

  • Limited public reviews available for the employer aspect.
  • Pricing information is not readily transparent.
  • Potential learning curve for new users unfamiliar with AI diagnostics.
  • Reliance on high-quality CT scan input for optimal results.
  • Specific customer support experiences are not widely documented.
  • Some users may prefer more customization options for reports.

Based on reviews from: G2, Glassdoor, Capterra, Healthcare IT News, Radiology Today, Reddit

Last updated: 2026-10-26

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Press & Coverage

PR Newswire
Imbio to be Acquired by 4DMedical Creating Comprehensive Cardiothoracic Image Analysis Portfolio
Imbio, a provider of medical imaging analysis technologies, announced a binding agreement to be acquired by 4DMedical. This merger aims to create a leading lung imaging AI suite, combining 4DMedical's functional analysis with Imbio's anatomical and tissue analysis.
2023-12
Respiratory Therapy
4DMedical to Acquire Imbio to Bolster Lung Imaging Tech
4DMedical's acquisition of Imbio will combine their technologies to offer a broader cardiothoracic analysis from standard chest CTs, providing functional, structural, and risk-based insights for lung and heart disease.
2023-12
4DMedical
4DMedical and Imbio Merge to Create Comprehensive Cardiothoracic Image Analysis Portfolio
This merger brings together 4DMedical's lung imaging technologies with Imbio's quantitative and personalized imaging analysis for acute and chronic diseases, aiming to revolutionize respiratory imaging and ventilation.
2023-12
4DMedical
Reducing the Burden on Healthcare Systems: The Efficiency of 4D Imaging in Respiratory Medicine
This article highlights how Imbio's FDA-cleared Coronary Artery Calcification (CAC) tool, now part of 4DMedical, can use existing chest CT scans to screen for coronary artery calcifications, improving efficiency in respiratory medicine.
2025-04
Healthcare IT Today
4DMedical Secures $10M Strategic Investment from Pro Medicus
4DMedical secured a $10 million strategic investment from Pro Medicus, a global leader in medical imaging software. This funding will accelerate 4DMedical's commercial pipeline and advance its CT:VQ product, building on its acquisition of Imbio in December 2023.
2025-08
4DMedical
4DMedical Secures US$100+ Million Funding to Accelerate U.S. Expansion and increase Technology Dominance in Software-Based Lung Imaging
4DMedical announced over US$100 million in new institutional placement to accelerate U.S. adoption of its CT:VQ™ product and boost R&D, further solidifying its technology lead in software-based lung imaging.
2026-01
accessdata.fda.gov
Imbio IQ-UIP Software Receives FDA 510(k) Clearance
Imbio's IQ-UIP software, a computer-aided tool for identifying radiological findings suggestive of usual interstitial pneumonia (UIP) in non-contrast chest CT scans, received FDA 510(k) clearance.
2024-12
Radiology Business
Medical AI specialist gains FDA clearance for new cardiothoracic imaging algorithm
Imbio received FDA 510(k) clearance for its AI-powered RV/LV Analysis tool, which automates heart ventricle measurements to provide an accurate ratio crucial for predicting cardiovascular risks like pulmonary embolism.
2021-03

Frequently Asked Questions

4DMedical (Imbio CAC Software) offers a range of tools for respiratory diagnostics and lung function assessment, including CT LVAS™ for lung ventilation analysis, LDAf™ and LDAi™ for functional and inspiratory lung density analysis, and LTA™ for lung tissue analysis. They also provide XV LVAS® for X-ray Velocimetry Lung Ventilation Analysis, which processes conventional X-ray scans to provide detailed functional lung health information.
4DMedical (Imbio CAC Software) leverages AI to transform standard medical images into detailed visual maps of a patient's condition and quantitative reports. This AI-powered approach assists in the detection, diagnosis, and management of chronic lung and cardiothoracic diseases by providing insights into lung structure and function, and identifying abnormalities.
Yes, 4DMedical's solutions are designed to integrate into existing hospital infrastructure, enhancing physician productivity and enabling more personalized patient care. Many of their products, such as XV LVAS®, can utilize existing hospital imaging equipment like fluoroscopic lung images, and their software operates on a Software-as-a-Service (SaaS) model.
4DMedical's products, including XV LVAS® and CT:VQ™, are FDA-cleared. Imbio's CAC™ software, now part of 4DMedical, is also FDA 510(k) cleared and CE Mark Certified, with TGA approval pending. The company designs and manufactures its devices under the Quality System Regulations outlined in 21 CFR Part 820.
4DMedical provides customer support through various channels, including phone and email. They offer support for IT/systems technical issues, clinical questions regarding analysis output, portal support, billing, payment, and general account inquiries.
4DMedical acquired Imbio in December 2023, a strategic move that significantly expanded its product portfolio and market presence, particularly in the U.S. healthcare market. This acquisition, along with strategic partnerships and recent funding, positions 4DMedical for continued growth and aims to enhance its offerings in respiratory and cardiothoracic imaging.
Yes, 4DMedical offers solutions like CT:VQ®, which provides non-contrast CT-based lung imaging for assessing both ventilation and perfusion. Additionally, XV LVAS® processes conventional X-ray scans to quantify regional lung ventilation without the need for contrast agents.

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