Brain Navi Biotechnology

Zhubei City, Hsinchu County, Taiwan  All Taiwan companies → Founded 2015
Medical Device / Hardware Specialty-Focused AI
Neurology Neurosurgery Radiology
Neurology AI Radiology & Imaging AI Surgical AI
Funding Raised (Pre-IPO fundraising round in 2025) — Undisclosed (NT$400 million in R&D investment mentioned, Pre-IPO round targeted US$10 million)

Products

NaoTrac
Brain Navi Biotechnology
Neurology AI
NaoTrac is an autonomous neurosurgical navigation robot with AI and machine vision, designed to improve accuracy, streamline procedures, and assist in surgical pathway planning with 3D vision.

See all 1 product →

About Brain Navi Biotechnology

Brain Navi Biotechnology is a leading Taiwanese surgical robotics company that specializes in developing innovative navigation and robotic techniques for neurosurgery. Their flagship product, NaoTrac, is an autonomous neurosurgical navigation robot designed to enhance surgical precision, efficiency, and accessibility. NaoTrac utilizes Brain Navi’s patented SMART (Surface Mapping Auto-registration Technology) platform, which integrates machine vision, AI technology, and a robotic arm to provide real-time imaging, precise surgical guidance, and minimally invasive outcomes.

For physicians, NaoTrac offers several key advantages. It supports various medical imaging modalities (CT and MRI) and is applicable to procedures such as brain tumor biopsy, deep brain stimulation (DBS), stereotactic electroencephalography (SEEG), endoscopic surgery, and external ventricular drain (EVD) placements. The system features fast and precise navigation with non-contact registration, pre-operative planning, and 3D vision for accurate anatomical location. Its unique autonomous procedure allows surgeons to plan the operation while NaoTrac acts as an assistant, precisely inserting instruments into the target lesion. NaoTrac’s patient registration process uses over 100,000 checkpoints, increasing accuracy to less than 0.5mm, and its AI technology facilitates intuitive facial recognition for flexible surgical positioning, including prone positions. The system also offers non-contact movement detection, recalibrating if the surgical bed moves incidentally. NaoTrac has received CE Mark, Taiwan FDA, and U.S. FDA 510(k) clearances, and has been adopted by hospitals internationally.

Focus Areas

neurosurgery surgical robotics AI in healthcare surgical navigation medical devices minimally invasive surgery

Business Intelligence

Key InvestorsKyber Capital, Sunsino Venture Group, RAPID-Health, Midana Capital
PartnershipsBenQ Medical Technology, Palex Healthcare, Medtreq Medical Equipment, Hualien Tzu-Chi Medical Center, Avalue Healthcare, First Securities Inc.
TechnologySMART (Surface Mapping Auto-registration Technology) platform, machine vision, AI algorithms, robotic technology, cloud-native (implied through AI and real-time data processing)
FDA Clearances1 cleared products (estimated)

What Physicians Need to Know

Neurosurgery & Surgical Robotics
Brain Navi Biotechnology specializes in neurosurgical robotics, with their flagship product NaoTrac being an autonomous surgical navigation robot designed for skull-based neurosurgery. It aims to make neurosurgical procedures more efficient, precise, and accessible, improving patient outcomes. NaoTrac has been successfully applied in various neurosurgical procedures, including biopsy and tumor ablation, intracranial hemorrhage (ICH), endoscopic surgery, external ventricular drainage (EVD), trigeminal nerve interventions, stereotactic radiofrequency (SRF), stereoelectroencephalography (SEEG), and deep brain stimulation (DBS). The company also offers KrystoLens, a single-use 3D neuro-endoscope for advanced neurosurgical visualization.
AI in Healthcare & Surgical Navigation
Brain Navi integrates AI, machine vision, and robotics in its surgical navigation systems. Their proprietary Surface Mapping Auto-registration Technology (SMART) is a core technology that combines machine vision, a robotic arm, and an in-house-designed algorithm for real-time imaging, precise surgery, and minimally invasive outcomes. AI technology in SMART focuses on stereotaxic positioning, using AI to detect facial landmarks, fuse medical images, and automatically map information, which reduces manual registration time and increases accuracy.
Medical Devices & Minimally Invasive Surgery
The company designs and develops high-precision robotic surgical navigation medical devices to assist surgeons and improve patient recovery. NaoTrac enables minimally invasive approaches, reducing risks and improving efficiency. KrystoLens, their single-use 3D neuro-endoscope, features a disposable design to reduce infection risk and streamline workflow, supporting precise visualization for minimally invasive procedures.
Key Differentiators
Brain Navi's key differentiators include their patented SMART Technology, which provides autonomous surface matching and locating, reducing pre-operative workflow and saving operating time. NaoTrac offers non-contact registration, eliminating the need for traditional stereotactic head frames. It also features robotic-active instrument recognition, making it compatible with standard surgical instruments. The system boasts high accuracy (less than 0.5mm) in patient registration and 3D medical image merging (CT/MR data). NaoTrac is also a C-arm/O-arm free solution, enhancing accessibility and user experience.
Technology Stack
The core of Brain Navi's technology stack is its SMART (Surface Mapping Auto-registration Technology) platform, which integrates machine vision, robotic technology, and AI algorithms. NaoTrac utilizes a robotic arm for precise instrument insertion and an intelligent 3D vision system that merges CT/MRI data with 3D images for accurate surgical pathways. The system also incorporates facial recognition for patient registration, using over 100,000 checkpoints to enhance accuracy.
Physician Tip

For physicians, Brain Navi's NaoTrac offers enhanced precision and efficiency in neurosurgery, potentially reducing surgical time and improving patient outcomes. The autonomous navigation and non-contact registration simplify the surgical workflow and shorten the learning curve for new users. The compatibility with standard surgical instruments allows surgeons to utilize tools they are already familiar with. The real-time imaging and 3D visualization capabilities provide superior guidance and planning. Furthermore, the system's ability to operate in various patient positions, including prone, offers greater flexibility in the operating room. The KrystoLens disposable endoscope also addresses concerns about infection control and workflow efficiency.

Brain Navi's NaoTrac supports various medical imaging modalities, including CT and MRI, for comprehensive surgical planning. The system's architecture, as seen with its collaboration with Avalue Healthcare, utilizes high-performance computing and AI PCs for real-time AI processing and reliable operation, suggesting potential for integration with advanced hardware platforms. The open approach to surgical tool recognition also implies a degree of flexibility for integration with existing surgical instrument sets.

Products by Brain Navi Biotechnology

1 product in the directory

NaoTrac
Brain Navi Biotechnology
Neurology AI
NaoTrac is an autonomous neurosurgical navigation robot with AI and machine vision, designed to improve accuracy, streamline procedures, and assist in surgical pathway planning with 3D vision.

What the Web Says

Brain Navi Biotechnology is a Taiwanese company specializing in neurosurgical navigation robots. Their flagship product, NaoTrac, utilizes AI, machine vision, and robotic-assisted surgery to enhance precision and streamline procedures. The company has received positive feedback from surgeons regarding the robot's accuracy, ability to reduce surgical time, and potential to improve patient outcomes and recovery. Brain Navi has obtained regulatory approvals including CE Mark, Taiwan FDA, and U.S. FDA clearance for NaoTrac. While product reviews are generally positive, there is limited information available on employer reviews from major platforms like Glassdoor or Capterra specifically for Brain Navi Biotechnology.

Overall: Positive

Strengths

  • NaoTrac significantly improves surgical accuracy (1-2mm deviation).
  • Reduces anesthesia and surgical time.
  • Streamlines surgical procedures and shortens the learning curve for surgeons.
  • Enhances patient well-being through less invasive interventions and faster recovery.
  • Utilizes advanced AI, machine vision, and robotic-assisted surgery with non-contact registration.
  • Versatile for various neurosurgical procedures including biopsies, tumor ablations, and EVD placements.

Limitations

  • Limited publicly available employer reviews on major platforms.
  • Some general reviews on platforms like G2 and Capterra (not specific to Brain Navi) mention initial fine-tuning for advanced workflows or being less beginner-friendly for complex software.

Based on reviews from: BioWorld, Brain Navi, PR Newswire, healthcare-in-europe.com, BioSpace, Indeed.com, G2, Capterra

Last updated: 2026-07-02

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Frequently Asked Questions

Brain Navi Biotechnology's flagship product is NaoTrac, an autonomous neurosurgical navigation robot. It is primarily used in neurosurgery to enhance precision and efficiency in procedures such as biopsies, tumor ablations, endoscopic interventions, EVD placement, SEEG, and Deep Brain Stimulation (DBS).
NaoTrac integrates AI, machine vision, and robotic technology to achieve real-time imaging, precise surgery, and minimally invasive outcomes. Its SMART (Surface Mapping Auto-registration Technology) enables non-contact, frameless patient registration in seconds, and the robotic arm assists surgeons in positioning instruments with optimal precision, potentially reducing surgical time and improving patient recovery.
Brain Navi Biotechnology has received FDA 510(k) clearance for NaoTrac in the United States, confirming its substantial equivalence in safety and effectiveness to legally marketed devices. Additionally, NaoTrac has obtained CE Mark approval for Europe and approval from the Taiwan Food and Drug Administration (TFDA) and India's CDSCO.
NaoTrac is designed with an intuitive and surgeon-friendly interface to streamline surgical procedures and reduce the learning curve. The system's autonomous navigation and pre-operative planning features, including 3D vision for precise anatomical location, aim to simplify the workflow and save operating time.
Brain Navi Biotechnology was founded in 2015 in Taiwan by surgeon and entrepreneur Jerry Chen, focusing on developing innovative neurosurgical solutions. The company has established partnerships, such as with Avalue Healthcare for its MedTech hardware platforms, and is actively expanding its global reach.
While NaoTrac is their flagship product for neurosurgery, Brain Navi Biotechnology has also developed the KrystoLens, a single-use 2D/3D neuro-endoscope. The company is also exploring robotic surgeries for other applications, including dental, lung, and breast treatments.

Investors

Who's funded Brain Navi Biotechnology.

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