Products

Leal Health (formerly Trialjectory)
Leal Health
Drug Discovery & Research
An AI-powered decision-support platform that matches cancer patients with relevant clinical trials, assisting oncologists in finding personalized treatment options.

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About Leal Health

Leal Health is an AI-powered, patient-centric decision-support platform designed to revolutionize access to advanced cancer treatment. For physicians, the platform serves as a crucial tool to expedite patient access to both clinical trials and FDA-approved therapies. Leveraging patented Natural Language Processing (NLP) and proprietary Large Language Models (LLMs), Leal Health analyzes complex medical documents, such as next-generation sequencing (NGS) and biopsy reports, to generate personalized treatment options and clinical trial matches based on specific eligibility criteria. This capability significantly reduces the burden on healthcare providers by streamlining the identification of suitable treatment pathways and clinical research opportunities for their cancer patients.

Beyond trial matching, Leal Health’s comprehensive platform offers integrated patient support resources, including assistance with financial aid, schedule management, and other logistical challenges that often hinder access to care. This holistic approach empowers patients to actively participate in their treatment journey while providing physicians with a more informed and engaged patient base. Furthermore, the platform provides biopharmaceutical companies with actionable insights derived from real-world patient data, which can inform clinical trial design, improve recruitment strategies, and offer real-time analytics on patient barriers and motivations, ultimately accelerating the development of patient-centric oncology research.

Focus Areas

AI-powered decision support clinical trial matching personalized cancer treatment patient journey navigation rare genetic diseases mental health

Business Intelligence

Key InvestorsInsight Partners, Contour Ventures, Rho Capital Partners, JAL Ventures, TIA Ventures, Amplifyher Ventures, Connecticut Innovations, ICONYC Labs, Ignite Healthcare Network
PartnershipsNexus Precision Health (acquisition), Cigna Healthcare, 90+ biopharma partners, two of the five largest U.S. health insurers
AcquisitionsAcquired by Nexus Precision Health (February 25, 2026)
TechnologyAI-powered, patented Natural Language Processing (NLP), Large Language Model (LLM), Generative AI (GenAI), Precise Medical Modeling, machine learning
FDA Clearances1 (for an FDA-approved cancer treatment decision support service) cleared products (estimated)

What Physicians Need to Know

AI-Powered Decision Support
Leal Health leverages advanced AI, including patented Natural Language Processing (NLP) and Machine Learning (ML), combined with a proprietary Large Language Model (LLM) and Precise Medical Modeling, to provide personalized treatment options. This includes both clinical trials and FDA-approved therapies, based on a patient's unique medical profile and diagnostics.
Clinical Trial Matching
Specializing in oncology, Leal Health offers the largest AI pre-screening platform for clinical trials, connecting cancer patients to relevant and available studies. The platform allows oncologists to customize searches by cancer subtypes and biomarkers, reducing reliance on unstructured data and expediting patient enrollment. It is directly connected to ClinicalTrials.gov.
Personalized Cancer Treatment
The platform's core mission is to democratize access to advanced cancer treatment by providing precision treatment options tailored to individual patient conditions. It offers a single point of access for patients to find all relevant, personalized treatment options, including standard-of-care and clinical trials.
Patient Journey Navigation
Leal Health provides a predictive patient tool designed to help cancer patients navigate their treatment journey at all stages. This includes educating patients and oncologists on options, removing barriers to care, offering financial aid identification, schedule management, and other patient support resources.
Key Differentiators
Leal Health stands out with its patient-first, unbiased approach to treatment options, ensuring no influence from pharmaceutical marketing. It offers comprehensive 1:1 clinical support and captures real-world patient data to evolve oncology research. The platform is recognized for its FDA-approved cancer treatment decision support and its focus on improving access for underrepresented populations.
Technology Stack
The technology stack is built around Artificial Intelligence (AI), specifically utilizing patented Natural Language Processing (NLP), Machine Learning (ML), and Generative AI (GenAI) with a proprietary Large Language Model (LLM) and Precise Medical Modeling. The platform is HIPAA & GDPR Compliant, ensuring robust data security and privacy.
Physician Tip

For physicians, Leal Health acts as a powerful, free-to-use decision support tool that significantly reduces the administrative burden of identifying clinical trial matches and personalized treatment options. It provides quick access to comprehensive, AI-generated patient-specific treatment lists, allowing for customized searches based on cancer subtypes and biomarkers. The platform empowers patient-physician collaboration by providing patients with well-researched options to discuss, fostering shared decision-making. Furthermore, it offers insights from real-world patient data and helps address health disparities by improving access for underserved populations, ultimately enhancing patient care and potentially improving outcomes.

Leal Health's platform is directly connected to ClinicalTrials.gov for comprehensive trial information. It supports medical record uploads for detailed patient profiling and integrates real-world data to inform treatment matching. While direct EHR integration details are not explicitly stated in the provided information, its functionality to upload medical records and generate shareable treatment lists is designed to complement existing clinical workflows. Leal Health has also established partnerships with organizations like Cigna Healthcare and Daichii-Sankyo to expand access to its program.

Products by Leal Health

1 product in the directory

Leal Health (formerly Trialjectory)
Leal Health
Drug Discovery & Research
An AI-powered decision-support platform that matches cancer patients with relevant clinical trials, assisting oncologists in finding personalized treatment options.

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Press & Coverage

PR Newswire
Leal Health Launches Next-Generation End-to-End Patient Support Platform Designed to Empower Cancer Patients to Navigate Their Treatment Journeys
Leal Health launched a GenAI single point of access technology to help cancer patients, caregivers, and healthcare providers understand diagnostics and identify personalized treatment options, including financial aid and schedule management.
2024-05
The Cancer Letter
Leal Health announces next-gen AI patient support platform to enable cancer treatment navigation
Leal Health introduced a new GenAI platform to assist cancer patients, caregivers, and healthcare providers in understanding diagnostics and finding personalized treatment options.
2024-05
PR Newswire
Leal Health to Unveil New Data on Benefits of Digital Health for Bridging Cancer Care Gaps at 2024 ASCO Annual Meeting
Leal Health announced it would present new data at the 2024 ASCO Annual Meeting on how digital health and AI platforms can help bridge cancer care gaps for diverse patient populations.
2024-06
ASCO Publications (Journal of Clinical Oncology)
Bridging the gap: Leveraging AI to enhance access to clinical trials for underrepresented and underserved populations with cancer.
This study, presented by Leal Health (formerly Trialjectory), investigates how digital health platforms and AI can improve access to clinical trials for underrepresented cancer patients by addressing barriers related to ethnicity, geographic location, and disease knowledge.
2024-05
PR Newswire
Leal Health Study Reveals Prostate Cancer Patients More Actively Engaged in Seeking Clinical Trials Significantly Earlier in Their Journey Compared to Other Solid Tumor Patients
A Leal Health study presented at the ASCO Genitourinary Cancers Symposium showed that prostate cancer patients actively seek clinical trial options much earlier than those with other solid tumors.
2024-01
Leal Therapeutics
Leal Therapeutics Announces $45 Million Financing to Progress Novel Therapies for Patients with Major Neurodegenerative and Neuropsychiatric Disorders
Leal Therapeutics secured $45 million in financing to advance its pipeline of antisense oligonucleotide (ASO) and small molecule therapeutics for central nervous system (CNS) disorders, including LTX-002 for ALS and LTX-001 for schizophrenia.
2024-10
ALS News Today
Leal raises $45M to advance LTX-002 to clinical trials for ALS
Leal Therapeutics raised $45 million to move its lead drug candidates, LTX-002 for ALS and LTX-001 for schizophrenia, into clinical trials.
2024-11
PR Newswire
Leal Therapeutics Doses First Patient in NeurALS Phase 1/2 Trial of LTX-002 for Amyotrophic Lateral Sclerosis (ALS)
Leal Therapeutics announced that the first patient has been dosed in the NeurALS Phase 1/2 trial for LTX-002, an investigational antisense oligonucleotide for amyotrophic lateral sclerosis (ALS).
2026-06

Frequently Asked Questions

Leal Health utilizes an AI-powered decision support platform with patented Natural Language Processing (NLP) to efficiently match cancer patients to relevant clinical trials based on their eligibility criteria, directly integrating with CT.GOV. This technology helps reduce physician workload by quickly identifying personalized treatment options and connecting patients directly to trial sites, enhancing access to advanced care.
Leal Health provides precision treatment options, including both clinical trials and FDA-approved therapies, tailored to a patient's unique medical profile and biomarkers. The platform also features a predictive patient tool and a next-generation GenAI single point of access technology to help patients navigate their entire treatment journey, offering support for understanding diagnostics, identifying financial aid, and managing schedules.
While Leal Health historically focused on cancer, its recent acquisition by Nexus Precision Health expands its mission to include rare genetic diseases and mental health conditions. The integrated platform is now designed to match patients with these conditions to appropriate therapies, clinical trials, or expanded access pathways at scale.
Leal Health is HIPAA and GDPR compliant, implementing strict security measures to protect patient medical information. These measures include industry-standard security systems, firewalls, access controls, and regular staff training to ensure the privacy and security of all confidential data.
Leal Health's platform is free for both patients and oncologists, aiming to democratize access to advanced cancer treatment. The company provides a dedicated team for 1:1 clinical support, answering questions regarding clinical trials, facilitating patient-doctor communication, and offering a GenAI-enabled chat resource for ongoing patient engagement and education.
Leal Health has established partnerships with leading advocacy and patient support organizations, pharmaceutical companies, biotech firms, and has engagements with major U.S. health insurers. The company, founded in 2017 and having secured significant funding, was acquired by Nexus Precision Health on February 27, 2026, indicating strong company stability and a strategic expansion into broader precision medicine.

Investors

Who's funded Leal Health.

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