OpenDNA
About OpenDNA
OpenDNA is a healthcare AI company focused on revolutionizing disease prevention and personalized medicine through the integration of advanced genomic analysis, clinical data, and artificial intelligence. Their platform processes millions of DNA bases, biomarkers, and clinical data points using proprietary AI frameworks, including machine learning and deep learning algorithms. This technology allows for the prediction, prevention, and personalized treatment of diseases with strong genetic predispositions.
For physicians, OpenDNA’s platform provides clinically actionable and easily understandable insights by distilling complex genetic data. The system has undergone rigorous validation, including a dataset of over 500,000 patients and two clinical trials, one in partnership with the Mayo Clinic, which is also an investor. The platform seamlessly integrates with Electronic Medical Records (EMRs), enabling easy test ordering, automatic data entry, and the full integration of interactive dashboards. These interactive dashboards allow clinicians and patients to adjust risk factors in real-time to visualize the impact on lifetime risk, fostering patient engagement and shared decision-making.
OpenDNA offers various AI-driven risk assessment tools, including CardioRisk+ for cardiometabolic heart disease, CancerRisk+ for breast, colon, and prostate cancer, TotalRisk+ for comprehensive polygenic-monogenic cancer risk, and PolyRisk+ which spans eight major disease areas. These tests cover 30 indications, enabling full-body risk profiling across categories such as cardiometabolic, cancer, autoimmune, eye, respiratory, neurological, mental health, and women’s health conditions. The company’s mission is to empower healthcare providers and patients with actionable insights that drive personalized treatment and preventive care strategies, ultimately improving health outcomes and reducing healthcare costs.
Focus Areas
Business Intelligence
| Key Investors | MindUP, Innovation Authority, International Business Machines, Medtronic, Pitango Venture Capital |
| Partnerships | Maxson, PartnerMD, Mayo Clinic, Harper Health, Cleveland Clinic, Blossom Family Medicine, Psifas, Dr. Sean Cahill |
| Technology | OpenDNA's AI Engine integrates genomics and clinical data for disease prediction and prevention. It utilizes validated Polygenic Risk Scores (PRS) and proprietary AI models that combine PRS with clinical data (family history, lifestyle) to create dynamic risk profiles. The platform offers interactive 'What-If' Dashboards for clinicians and patients to adjust risk factors in real-time and see the impact on lifetime risk. It is designed for seamless integration with Electronic Medical Records (EMRs). |
What Physicians Need to Know
OpenDNA's platform is designed to seamlessly integrate into clinical workflows, providing automated data pull from EMRs and Gen AI-based decision support for real-time, actionable insights. Physicians can utilize interactive 'what-if' dashboards to engage patients in shared decision-making by demonstrating how adjusting risk factors impacts lifetime risk. The system empowers clinicians with clear, immediate insights, which is particularly beneficial for busy family doctors. OpenDNA's tools have shown to impact clinical decision-making in a significant percentage of cases, leading to increased patient awareness, education, and modifications in management plans, including new statin recommendations and lifestyle adjustments.
OpenDNA's patented platform is built for seamless integration into existing clinical workflows and EMR systems, facilitating automated data pull and providing interactive dashboards that can be shared with patients. They have also engaged in collaborations with institutions like Mayo Clinic for pilot clinical studies and Psifas (the Israeli National Initiative for Personalized Medicine) to develop AI models for predicting genetic risk for common diseases, enriching biobank data for future research.
What the Web Says
OpenDNA is a precision medicine AI platform that utilizes polygenic risk scores and clinical data to predict disease risk and support clinical decisions, particularly for cardiometabolic diseases and cancer. They partner with healthcare providers to offer genetic screening tests and integrate results into electronic medical records. There appears to be another entity also named OpenDNS, which is a cloud-delivered DNS security platform now owned by Cisco, offering security and content filtering services. This review focuses on the precision medicine AI platform, OpenDNA.
Overall: PositiveStrengths
- Utilizes state-of-the-art AI technology to analyze DNA and clinical attributes for disease risk assessment.
- Provides actionable insights for preventive care, lifestyle changes, and treatment options.
- Seamlessly integrates with electronic medical records (EMR) and physician workflows.
- Offers interactive software for physicians and patients to visualize the effect of risk factor changes.
- Covers both monogenic and polygenic risks.
- Collaborates with leading academic and healthcare institutions.
Limitations
- No specific product or employer reviews found on G2, Glassdoor, or Capterra for the precision medicine AI platform.
- Limited public reviews available, making it difficult to gauge widespread user satisfaction or employer sentiment.
Based on reviews from: athenahealth, EIN Presswire, FirstWord HealthTech
Last updated: 2026-06-23
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