Products

Pearl Second Opinion®
Pearl
Dental AI
Pearl Second Opinion® offers FDA-cleared AI for 2D and 3D dental X-ray analysis, assisting in the detection of pathologies like caries, calculus, bone loss, and periapical radiolucencies, leading to improved diagnostic accuracy and patient trust.
Second Opinion
Pearl
Dental AI
Pearl's Second Opinion is an FDA-cleared AI tool that assists dentists in real-time analysis of dental X-rays, detecting pathologies like caries and bone loss, and enhancing patient communication for improved treatment acceptance.
Second Opinion® Pediatric
Pearl
Dental AI
Pearl's Second Opinion® Pediatric is an FDA-cleared AI platform that provides real-time analysis of dental X-rays for pediatric patients as young as four, enhancing caries detection and improving communication with a kid-friendly interface.

See all 9 products →

About Pearl

Pearl is a global leader in dental artificial intelligence (AI) solutions, dedicated to advancing patient care within the dentistry sector. The company develops sophisticated AI and computer vision technologies designed to enhance the efficiency, accuracy, transparency, and overall quality of dental services. Their comprehensive platform offers a suite of tools, including Second Opinion® for AI-powered detection of pathologies in both 2D X-rays and 3D cone beam computed tomography (CBCT) images, Practice Intelligence® for generating actionable insights from practice data, Precheck™ for accurate cost estimations and insurance coverage breakdowns, Calibrate® for AI-guided clinical training, and Pearl Voice™ for ambient voice AI in clinical notes and periodontal charting.

Pearl’s AI solutions empower dentists to make more precise clinical decisions, communicate effectively with patients about their oral health, and streamline various aspects of practice operations. The company has achieved significant regulatory milestones, including FDA clearance for its AI software to identify multiple pathologies and conditions in dental X-rays, encompassing both 2D and 3D imaging modalities. This widespread regulatory clearance, spanning over 120 countries, underscores Pearl’s commitment to establishing AI as a fundamental utility in dental practices worldwide, ultimately transforming the dental care experience.

Focus Areas

Dental AI diagnostic accuracy treatment planning practice performance patient communication insurance verification clinical training 2D radiography analysis 3D CBCT imaging analysis computer vision machine learning

Business Intelligence

Key InvestorsLeft Lane Capital, Smash Capital, Alpha Partners, Craft Ventures, Neotribe Ventures, Dental Innovation Alliance, American Dental Association
PartnershipsPDS Health, Coast Dental, DECA Dental Group, Peak, Software of Excellence, Midwest Dental Equipment & Supply, Ora, Tab32, Archy, Patterson Dental, Plandent, Onsite Dental, SOTA Cloud
TechnologyCloud-native AI platform utilizing computer vision and machine learning algorithms (trained on millions of X-ray images), deep learning frameworks (TensorFlow, PyTorch), NVIDIA GPUs for training, and Amazon Web Services (AWS) cloud for inference. Integrates with various imaging and practice management systems.
FDA Clearances26 cleared products (estimated)

What Physicians Need to Know

Diagnostic Accuracy (2D & 3D Radiography)
Pearl's FDA-cleared AI, including Second Opinionu00ae for 2D X-rays and Second Opinion 3Du00ae for CBCT, provides real-time analysis to detect pathologies such as caries, bone loss, calculus, periapical radiolucencies, and restoration issues. It boasts an independently validated 94% accuracy in detecting dental disease, helping clinicians identify 37% more disease.
Treatment Planning Optimization
The AI solutions support smarter, personalized treatment planning by analyzing patient data, treatment histories, and clinical outcomes. They help predict results, identify risks, and support evidence-based decision-making, leading to higher success rates and greater patient satisfaction.
Practice Performance & Efficiency
Pearl's Practice Intelligenceu00ae turns practice data into actionable insights to boost growth, streamline operations, and improve care. It helps pinpoint priority patients, optimizes scheduling, and can lead to an average of $15,000 more production per month and save 20+ hours per week for administrative tasks.
Enhanced Patient Communication
AI-highlighted images with clear, color-coded findings and patient-friendly reports (e.g., 'Tooth Parts' mapping, 'Sugar Bugs' for pediatric caries) enhance patient understanding and trust, driving up to 30% more treatment acceptance.
Automated Insurance Verification
Prechecku2122 automatically verifies insurance for scheduled patients and pulls detailed benefits breakdowns in seconds, eliminating manual calls and paperwork. This streamlines front desk workflows, reduces claim denials, and accelerates the revenue cycle.
Clinical Training & Education
Pearl offers AI-guided clinical training through platforms like Calibrateu00ae and Pearl Academy, providing on-demand courses, live workshops, and virtual simulations to drive consistent, outstanding care and improve diagnostic accuracy and clinical skills.
2D Radiography Analysis
Second Opinionu00ae is specifically designed for real-time AI-assisted interpretation of 2D radiographs (intraoral and OPGs), helping dentists identify a range of dental conditions from incipient caries to bone loss with high precision.
3D CBCT Imaging Analysis
Second Opinion 3Du00ae is the first FDA-cleared AI for 3D radiology, transforming complex CBCT scans into intuitive, color-coded 3D structures with automatic segmentation. This expedites review, clarifies critical findings, and aids in precise planning for procedures like implant placement.
Computer Vision & Machine Learning Core
At its foundation, Pearl leverages advanced computer vision and deep learning machine learning algorithms. These systems are trained on the world's largest collection of expertly annotated dental radiographs to analyze images pixel by pixel, recognize patterns, and detect pathologies with unmatched precision.
AI-Powered Clinical Documentation
Pearl Voiceu2122 is an ambient voice AI assistant that passively listens during appointments, captures and transcribes natural doctor-patient conversations, and converts them into structured clinical notes, including SOAP notes and periodontal charts, reducing administrative burden.
Physician Tip

For physicians (dentists), Pearl stands out by offering a comprehensive, FDA-cleared AI platform that acts as an 'always-on' diagnostic assistant, significantly enhancing diagnostic confidence and consistency by catching subtle issues and providing objective, evidence-based insights. The patient-facing nature of Pearl's AI, with its clear visual overlays and reports, empowers patients to better understand their oral health and treatment needs, fostering trust and increasing treatment acceptance. Furthermore, the automation of administrative tasks like insurance verification and clinical documentation frees up valuable staff time, allowing the dental team to focus more on patient care and practice growth. Pearl's support for both 2D and 3D imaging workflows, coupled with its continuous learning algorithms, ensures that practices remain at the forefront of dental technology, improving both clinical outcomes and operational efficiency.

Pearl's platform is designed for integration with most dental practice management systems (PMS) and imaging software. Supported software includes PlanetDDS, Eaglesoft, Fuse, Open Dental, Curve Dental, Patterson Dental, Romexis, Vatech, Medit, Dentally, Exact, Oryx, and Sota Cloud. This allows for a seamless workflow where AI detections and insights flow directly into existing systems, strengthening documentation and patient communication.

Products by Pearl

9 products in the directory

Pearl Second Opinion®
Pearl
Dental AI
Pearl Second Opinion® offers FDA-cleared AI for 2D and 3D dental X-ray analysis, assisting in the detection of pathologies like caries, calculus, bone loss, and periapical radiolucencies, leading to improved diagnostic accuracy and patient trust.
Second Opinion
Pearl
Dental AI
Pearl's Second Opinion is an FDA-cleared AI tool that assists dentists in real-time analysis of dental X-rays, detecting pathologies like caries and bone loss, and enhancing patient communication for improved treatment acceptance.
Second Opinion® Pediatric
Pearl
Dental AI
Pearl's Second Opinion® Pediatric is an FDA-cleared AI platform that provides real-time analysis of dental X-rays for pediatric patients as young as four, enhancing caries detection and improving communication with a kid-friendly interface.
Second Opinion® 3D
Pearl
Dental AI
Pearl's Second Opinion® 3D is an FDA-cleared AI tool that transforms dental CBCT scans into clear, actionable 3D insights for faster, more accurate diagnoses and treatment planning in dentistry.
Second Opinion CC
Pearl
Dental AI
Pearl's Second Opinion® is an FDA-cleared AI software that assists dentists in interpreting 2D and 3D dental X-rays, detecting a wide range of pathologies with high accuracy, enhancing diagnostic consistency, and improving patient communication and case acceptance.
Second Opinion Periapical Radiolucency Contours
Pearl
Dental AI
Pearl's Second Opinion AI platform provides advanced segmentation for periapical radiolucency detection, offering precise, AI-generated polygonal contours for enhanced diagnostic accuracy and patient communication.
Second Opinion® BLE
Pearl
Dental AI
Pearl's Second Opinion® BLE is an FDA-cleared AI tool for automated bone level measurement in dental X-rays, enhancing periodontal evaluation and patient communication for dental professionals.
Second Opinion® CS
Pearl
Dental AI
Pearl's Second Opinion® CS is an AI-powered radiology solution for dental clinicians that provides real-time pathology detection, automated clinical annotation, measurement tools, and case presentation functions.
Second Opinion® Panoramic
Pearl
Dental AI
Pearl's Second Opinion® Panoramic is an FDA-cleared AI platform for dental professionals, enhancing the analysis of panoramic radiographs by providing real-time, color-coded detection of pathologies and supporting improved diagnostics, patient communication, and treatment planning.

What the Web Says

Pearl is a company with diverse offerings, including tutoring software, AI solutions for dental professionals, and value-based care intelligence for healthcare providers. Reviews indicate a generally positive sentiment for its products, particularly praising ease of use, comprehensive features, and strong customer support. However, some specific products and company cultures receive mixed or negative feedback.

Overall: Mixed

Strengths

  • Easy to use interface and onboarding for tutoring software.
  • Comprehensive features for tutoring businesses, including scheduling, notifications, and reporting.
  • Strong customer service and responsiveness for tutoring software.
  • AI solutions for dental professionals assist in earlier and more precise issue identification.
  • Value-based care intelligence helps healthcare providers identify risks and improve patient outcomes.
  • Proactive and responsive IT managed services.

Limitations

  • Tutoring software storefront not integrated for currencies other than USD.
  • AI for dental imaging can have false positives and customer support can be lacking.
  • Some negative employer reviews for 'Pearl Organisation' on Reddit, citing toxic culture and unprofessional management.
  • Pearl Healthcare (a different entity) has low ratings for work-life balance, pay, and management.
  • Pearl.com (AI Chatbots) has limited reviews, making it difficult to assess.
  • Higher-end Pearl drums depreciate faster than other brands.

Based on reviews from: Capterra, G2, Reddit, Indeed.com, Pearl Health, Forbes, Cloudtango

Last updated: 2026-07-19

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Press & Coverage

MedCity News
Pearl Health Lands $110M to Support Value-Based Care for Medicare Patients
Pearl Health, a healthcare technology company, secured $110 million in funding to expand its AI platform and grow partnerships for value-based care for Medicare patients. The company aims to reduce costs and improve patient outcomes by helping providers manage risk and automate administrative tasks.
2026-07
Fierce Healthcare
Pearl Health banks $110M in fresh funding to build out tech and AI for Medicare providers
Pearl Health raised $110 million in debt and equity to enhance its AI platform for Medicare providers, including AI agents for administrative tasks. The company supports over 10,000 providers across 40 states, serving more than 250,000 Medicare beneficiaries.
2026-07
PR Newswire
Pearl Health Raises $110 Million to Expand Its AI Platform Helping Providers Deliver Better Outcomes at Lower Cost for Medicare Patients
Pearl Health announced a $110 million capital raise to expand its AI platform, accelerate growth in health system and payer partnerships, and expand into Medicare Advantage. The company reached profitability in 2025 and projects $500 million in gross healthcare system savings by the end of 2026.
2026-07
Forbes
Pearl Health Raises $110 Million To Expand AI Platform For Medicare Care
Pearl Health secured $110 million in funding, including a $50 million equity round led by Andreessen Horowitz, to expand its AI platform for Medicare patients. The company aims to help providers shift to outcomes-based care and has achieved profitability in 2025.
2026-07
Axios
Pearl Health raises $110 million for Medicare-focused tech
Pearl Health, a health tech company focused on Medicare, raised $110 million in a mix of debt and equity financing. Andreessen Horowitz led the $50 million Series C equity tranche, bringing the company's total equity raised to $125 million.
2026-07
PR Newswire
Pearl Health Releases 2026 Top 50 Value-Based Care Thinkers Report
Pearl Health released its fifth annual Top 50 Value-Based Care Thinkers Report, recognizing leaders driving measurable impact in healthcare's transition to value-based care. The report highlights a shift towards execution and outcomes in defining leadership in the field.
2026-04
Hospitalogy
Pearl Health: The VBC Math That Should Change Your Mind
This article discusses six lessons from Pearl Health's CEO on enabling value-based care at scale, emphasizing the importance of data infrastructure. It also mentions an upcoming peer-reviewed journal article by Pearl Health demonstrating improved MLR performance for their clients.
2026-04
BMJ Evidence-Based Medicine
147 Clinical pearl: a voice enabled point of care clinical search engine & clinical question capturing platform
This article describes 'Clinical Pearl,' a voice-enabled point-of-care clinical search engine and question-capturing platform. It aims to enhance reflective learning, identify knowledge gaps, and provide personalized evidence-based practice for clinicians.
2023-09

Frequently Asked Questions

Pearl's AI, particularly its Second Opinionu00ae platform, is FDA-cleared for real-time pathology detection in 2D radiographs (bitewing, periapical, panoramic) and 3D CBCT scans, making it the first and only dental AI company with such comprehensive clearance. It identifies conditions like caries, bone loss, and periapical pathologies, with studies showing high sensitivity and specificity, and is cleared in over 120 countries.
Pearl's AI solutions, like Second Opinionu00ae and Practice Intelligenceu00ae, provide data-driven insights from radiographic analysis to support more precise treatment planning and identify previously undetected conditions. This can lead to increased treatment acceptance by patients, optimized operational workflows, and improved revenue for the practice.
Pearl's AI generates clear, color-coded visual overlays on radiographs and comprehensive reports, making complex diagnoses easily understandable for patients. This transparency fosters trust, helps patients visualize their oral health conditions, and can significantly boost treatment acceptance rates.
Pearl provides various training resources, including live webinars, interactive online courses through Pearl Academy, and partnerships with educational platforms like RipeGlobal. These initiatives aim to enhance AI literacy, accelerate skill development, and ensure consistent, high-quality care by integrating AI into clinical and administrative workflows.
Pearl's core products include Second Opinionu00ae for real-time 2D and 3D radiographic pathology detection, Practice Intelligenceu00ae for data-driven operational insights, Prechecku2122 for insurance verification, Calibrateu00ae for clinical training, and Pearl Voiceu2122 for ambient clinical notes. These platforms utilize advanced computer vision and deep learning algorithms, trained on extensive datasets, to analyze images at a pixel level, detect anomalies, and provide precise measurements across various imaging modalities.
Pearl operates on a Software as a Service (SaaS) subscription model, with a monthly fee (e.g., around $299 USD/month for Second Opinion) and a one-off setup fee covering integration, initial training, and historical data review. They offer ongoing support, including access to the Pearl Success Hub and live training webinars, though some user reviews mention customer support can be inconsistent.
Pearl demonstrates strong company stability, having secured a significant $58 million Series B funding round and strategic investments from organizations like the American Dental Association. They have expanded their global partner network, integrating with leading software platforms and DSOs like Straine Dental Management and Partnerships for Dentists, reaching over 150,000 dentists worldwide.

Investors

Who's funded Pearl.

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