Second Opinion CC

by Pearl  · Based in United States → — Dentistry's most powerful chairside AI platform.
Dentistry
Website
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Subscription-based, starting at $299/month.
Regulatory Status Disclosed

Overview

Pearl’s Second Opinion® is an advanced artificial intelligence (AI) software designed to assist dental professionals in the interpretation of dental radiographs. Leveraging machine learning models trained on extensive datasets of expertly annotated dental X-rays, the platform enhances the accuracy, speed, and consistency of diagnostic evaluations. It utilizes state-of-the-art computer vision technology to detect and segment anatomical structures, tooth parts, and various dental pathologies, including caries (tooth decay), calculus (tartar), bone loss, periapical radiolucencies, and impacted third molars.

The software provides real-time analysis and presents findings with clear, color-coded visual overlays directly on the X-rays, facilitating better patient communication and education. This objective, data-based approach helps patients understand their diagnoses and treatment options, leading to increased case acceptance. Second Opinion® integrates seamlessly with major dental imaging systems and practice management software, streamlining clinical workflows and improving practice efficiency. It supports both 2D (bitewing, periapical, panoramic) and 3D (CBCT) radiographic modalities, with specialized features like automated bone level measurement and pediatric caries detection for patients as young as 4 years old.

Reviewed by Pouyan Golshani, MD — Interventional Radiologist

Key Features

  • AI-powered detection of dental pathologies (caries, calculus, bone loss, periapical radiolucency, impacted third molars)
  • Real-time analysis and annotations on 2D and 3D X-rays
  • Advanced segmentation for precise lesion visualization
  • Color-coded visuals and tooth part mapping for enhanced patient communication
  • Compatibility and integration with major dental imaging and practice management systems
  • Support for 2D (bitewing, periapical, panoramic) and 3D (CBCT) radiographs
  • Automated bone level measurement (Second Opinionu00ae BLE)
  • Pediatric caries detection for patients aged 4+
  • Cloud-based platform for accessibility and continuous updates
  • Exportable patient health reports with annotated visuals

Use Cases

  • Enhancing diagnostic accuracy and consistency in dental practices
  • Improving patient education and fostering trust through clear visual explanations
  • Increasing case acceptance for recommended treatments by up to 30%
  • Streamlining clinical workflows and improving practice efficiency
  • Supporting precise treatment planning across various dental specialties (e.g., implantology, orthodontics, oral surgery)
  • Facilitating staff training and standardizing image capture quality

What Physicians Need to Know

Dental X-Ray Analysis
Provides real-time AI analysis and annotations for periapical, bitewing, and panoramic radiographs, identifying various pathologies including dental caries, discrepancies at restoration margins, calculus, and periapical radiolucency.
Caries Detection Accuracy
Demonstrates industry-leading accuracy in detecting and segmenting caries, including incipient and progressed decay. Studies indicate high sensitivity for caries detection, with reported 94% accuracy in detecting dental disease and 88% lesion level sensitivity for overall caries detection.
Periodontal Assessment
Aids in periodontal assessment by detecting bone loss and periapical radiolucency, which are critical indicators of periodontal conditions.
Treatment Planning AI
Enhances diagnostic precision and supports treatment planning by providing AI-triggered second opinions. It can compare clinician-proposed treatment plans with AI recommendations, potentially increasing the F1-score for decision-making.
Dental Imaging Integration (CBCT/Panoramic)
Offers seamless integration with CS Imaging software for 2D X-rays and features a dedicated 'Second Opinion 3D' for CBCT scans, providing automated segmentation, color-coded anatomical insights, and clear 3D visualizations. It also supports panoramic radiographs for detecting caries, periapical radiolucency, and impacted third molars.
Practice Management Integration
Integrates with leading dental practice management systems such as Software of Excellence and EXACT dental software, streamlining workflows and enhancing clinical support within the existing practice infrastructure.
Patient Communication Tools
Utilizes clear, color-coded visuals, tooth parts mapping, and comparison modes to help patients easily understand their diagnoses and proposed treatment plans, which can significantly boost case acceptance.
Orthodontic Planning
Detects impacted third molars in panoramic radiographs, providing valuable information relevant to orthodontic assessment and planning.
Physician Tip

Second Opinion by Pearl serves as a powerful adjunctive tool, enhancing diagnostic accuracy and consistency in dental radiography. Leverage its real-time AI analysis for caries, bone loss, and other pathologies to confirm your findings and gain a 'second set of eyes.' Utilize the clear visual annotations and patient communication tools to educate patients effectively, fostering trust and improving treatment acceptance. Remember that AI is a support system; clinical judgment remains paramount.

Second Opinion seamlessly integrates with popular dental imaging software such as CS Imaging. Furthermore, it offers integration with practice management systems like Software of Excellence and EXACT dental software, facilitating a streamlined workflow from image acquisition and AI analysis to patient management and treatment planning. A dedicated 'Second Opinion 3D' module is available for advanced CBCT analysis.

Details

Category Dental AI
Pricing Subscription-based, starting at $299/month.
  • Starting at $299 USD/month, plus a one-off setup fee of $500 USD
  • No lock-in contract
  • Volume-based pricing is available for larger organizations
DeploymentCloud-based
Compliance
BAA AvailableUnknown AI-estimated
HIPAA CompliantUnknown AI-estimated
FDA Status Yes. AI-estimated

Pearl's Second Opinion® holds multiple FDA 510(k) clearances. This includes K203936 for initial 2D radiographic analysis (caries, calculus, bone loss), K242522 (among others) for advanced segmentation of caries and periapical radiolucency, and subsequent clearances for 3D CBCT imaging, panoramic X-rays, automated bone level analysis (Second Opinion® BLE), and pediatric caries detection for patients as young as 4 years old (Second Opinion® Pediatric).
Integrations
EHR Not specified
Specialties Dentistry

Ratings & Reviews

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Clinical Value
Ease of Use
Integration
Support & Docs
Value for Money

Press & Coverage

FDA
Second Opinionu00ae Pediatric (K243893) u2014 FDA 510(k)
This regulatory announcement details the FDA 510(k) clearance for Pearl, Inc.'s Second Opinionu00ae Pediatric, a CADe software designed to aid in the detection of caries in bitewing and periapical radiographs for patients aged 4 and older. The device uses machine learning to analyze images and highlight potential caries, serving as a second reader for dental clinicians.
2025-05
Odontologos.com
FDA-Approved AI Solutions in Dental Imaging: A Narrative Review of Applications, Evidence, and Outlook
This narrative review provides a comprehensive overview of FDA-cleared AI solutions in dental imaging, including Pearl's Second Opinion CC (K242522) which received 510(k) clearance on January 16, 2025. It notes that while Pearl's core Second Opinion product has peer-reviewed support, its submodules like Second Opinion CC, CS, BLE, 3D, periapical radiolucency contours, and pediatric versions currently lack independent peer-reviewed evidence.
2026-02
PMC
FDA-Approved AI Solutions in Dental Imaging: A Narrative Review of Applications, Evidence, and Outlook - PMC
This review, published in PMC, details the performance outcomes reported by the FDA for Second Opinion CC, including a standalone sensitivity of 90% and a Dice (segmentation accuracy) of 0.73, indicating it is noninferior to the original Second Opinion. It also highlights that while some AI platforms have strong external validation, many, including Pearl's Second Opinion CC and other submodules, primarily rely on regulatory or manufacturer-reported data.
2025-12

Videos

Product demos, reviews, and walkthroughs for Second Opinion CC.

View all on YouTube

Frequently Asked Questions

Pearl's Second Opinion AI integrates seamlessly with existing imaging software, automatically analyzing 2D radiographs (intraoral, OPGs) and 3D CBCT scans in real-time. It acts as a 'second set of eyes,' highlighting potential pathologies such as decay, bone loss, calculus, periapical radiolucencies, and restoration discrepancies.
Yes, Pearl's Second Opinion AI is FDA-cleared as a chairside detection aid for a wide range of dental conditions in both 2D and 3D radiology, and holds EU-MDR certification and clearances in over 100 countries. However, it is an assistive radiologic tool and not intended for use as a diagnostic device; all final diagnostic decisions must be made by a licensed dental professional.
Pearl states its AI detects dental disease with 94% accuracy and is validated by an independent third party. While it can highlight areas of interest, the software may sometimes make detections that a clinician disagrees with, and users should disregard any inaccurate findings. Some user feedback has noted potential for false positives, particularly with interproximal decay, and issues with coloration.
Pearl's Second Opinion operates on a subscription-based model, which typically includes a one-off setup fee. This setup fee can be around $500 USD, covering image integration, team training, and ongoing support. Monthly subscription costs have been reported to be approximately $350.
A primary alternative is Overjet, which is also FDA-cleared and offers comprehensive diagnostic support, with a focus on quantifying bone levels and AI-powered image enhancement. Other dental AI solutions include VideaAI and CranioCatch Clinic, which also aim to improve diagnostic accuracy and workflow efficiency.
Second Opinion AI enhances patient communication by providing clear, color-coded AI highlights and annotated visuals directly on X-rays, making it easier for patients to visualize and understand their diagnoses. This improved clarity helps build trust and can lead to higher case acceptance, with some practices reporting up to a 30% increase in accepted treatment.
Yes, Pearl offers Second Opinion 3D, an FDA-cleared AI solution for CBCT imaging that transforms complex scans into clear, actionable 3D insights. It provides automated segmentation, color-coded anatomy, and highlighted findings, allowing for rapid review and planning for procedures like implant placement.

Compare Second Opinion CC

VS
Second Opinion CC vs Videa Caries Assist
Dental AI Direct · 90/100
Both Pearl's Second Opinion CC and Videa Caries Assist are FDA-cleared, cloud-based AI tools designed to enhance dental diagnostics from X-rays, particularly for caries, bone loss, and periapical…
VS
Second Opinion CC vs Videa Dental Assist
Dental AI Direct · 85/100
Pearl's Second Opinion CC focuses intensely on AI-powered detection and analysis of dental pathologies across 2D and 3D X-rays, emphasizing diagnostic consistency and detailed visualizations for patient communication.…
VS
Second Opinion CC vs Videa Perio Assist
Dental AI Direct · 80/100
These tools are directly comparable, as both offer FDA-cleared AI for bone level measurement and visualization to assist in periodontal disease assessment. While Tool A provides a broader…
VS
Second Opinion CC vs Relu Creator
Dental AI Adjacent · 70/100
Tool A (Second Opinion CC) is designed for AI-powered diagnostic assistance, focusing on detecting pathologies in 2D and 3D dental X-rays to improve diagnostic consistency and patient communication.…

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Suggest an Edit → | Last Verified: 2026-04-18 | First Added: 2026-04-18

Investors who backed Second Opinion CC

Funded through the company that built this tool.

Left Lane Capital
VC T1
New York, United States
$5M-$25M
Left Lane Capital is a New York-based growth-equity firm that has built a focused practice around consumer-facing internet and software companies, with…
Care Delivery / Tech-Enabled Services Digital Health
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